Automated detection of c-Fos-expressing neurons using inhomogeneous background subtraction in fluorescent images [0.03%]
使用荧光图像中的非均匀背景减除自动检测c-Fos阳性神经元
Hisayuki Osanai,Mary Arai,Takashi Kitamura et al.
Hisayuki Osanai et al.
Although many methods for automated fluorescent-labeled cell detection have been proposed, not all of them assume a highly inhomogeneous background arising from complex biological structures. Here, we propose an automated cell detection alg...
Xuefeng Yang,Xiu Miao,Franziska Schweiggart et al.
Xuefeng Yang et al.
The consolidation of long-term memory is thought to critically rely on sleep. However, first evidence from a study in Drosophila suggests that hunger, as another brain state, can benefit memory consolidation as well. Here, we report two hum...
Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells [0.03%]
参与情景记忆提取的海马回活化神经元的结构突触特征
Panthea Nemat,Salimat Semenova,Rolinka J van der Loo et al.
Panthea Nemat et al.
Learning enhances hippocampal engram cell synaptic connectivity which is crucial for engram reactivation and recall to natural cues. Memory retrieval engages only a subset of the learning-activated ensemble, indicating potential differences...
Brain-wide immunolabeling and tissue clearing applications for engram research [0.03%]
全脑免疫标记和组织清除在记忆痕迹研究中的应用
Alessandra Franceschini,Michelle Jin,Claire W Chen et al.
Alessandra Franceschini et al.
In recent years, there has been significant progress in memory research, driven by genetic and imaging technological advances that have given unprecedented access to individual memory traces or engrams. Although Karl Lashley argued since th...
GluA1-containing AMPA receptors are necessary for sparse memory engram formation [0.03%]
含GluA1的AMPA受体对于稀疏记忆痕形成是必需的
Thije S Willems,Hui Xiong,Helmut W Kessels et al.
Thije S Willems et al.
Memory formation depends on the selective recruitment of neuronal ensembles into circuits known as engrams, which represent the physical substrate of memory. Sparse encoding of these ensembles is essential for memory specificity and efficie...
Guillem Esber,Geoffrey Schoenbaum,Mihaela D Iordanova
Guillem Esber
Male rats choose higher doses of nicotine in anticipation of a signalled period of drug non-availability [0.03%]
雄性大鼠在预期出现药物不可获得的信号期间选择更高剂量的尼古丁
Timothy J Hill,Nathan M Holmes,Kelly J Clemens
Timothy J Hill
Humans and animals use information about future access to rewards to influence their behaviour in the present, however the evidence for this is largely anecdotal. Here we use the nicotine intravenous self-administration paradigm to ask whet...
Aversive social learning with a dead conspecific is achieved by Pavlovian conditioning in crickets [0.03%]
通过帕夫洛夫条件作用克氏田园蚁蟋与死去的同种个体之间产生厌恶社交学习行为
Kohei Hashimoto,Kanta Terao,Makoto Mizunami
Kohei Hashimoto
Social learning, learning from other individuals, has been demonstrated in many animals, including insects, but its detailed neural mechanisms remain virtually unknown. We showed that crickets (Gryllus bimaculatus) exhibit aversive social l...
Megan Kelly,Merrick Garner,Emily M Cooper et al.
Megan Kelly et al.
The ability to choose between options that differ in their risks and rewards depends on brain regions within the mesocorticolimbic circuit and regulation of their activity by neurotransmitter systems. Dopamine neurotransmission in particula...
Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood [0.03%]
早期母婴分离对青少年及成年期受惩罚驱动的冒险决策的影响研究
Grace L Minnes,Anna J Wiener,Audrey S Pisahl et al.
Grace L Minnes et al.
Early life adversity (ELA) is associated with a multitude of neural and behavioral aberrations. To develop treatments to mitigate the effects of ELA, it is critical to determine which aspects of cognition are affected and when these disturb...