Andrew T Perl,Juan Wu,John D Dong et al.
Andrew T Perl et al.
Alzheimer's Disease (AD) remains the leading cause of dementia globally, yet the exact etiology is not well defined and effective treatments remain unavailable. Here, we report that deletion of the immune checkpoint receptor lymphocyte acti...
Decoding Parkinson's progression: A multi-modal SuStaIn ensemble approach validated on real-world PPMI data [0.03%]
Moad Hani,Saïd Mahmoudi,Mohammed Benjelloun
Moad Hani
Background: Parkinson's disease (PD) exhibits substantial heterogeneity in clinical presentation and longitudinal progression, complicating prognosis, trial design, and precision therapeutics. While the Subtype and Stage ...
Suppression of neuronal p27 impairs cognitive function in middle-aged mice [0.03%]
神经元p27抑制损害中年小鼠认知功能
Noelle I Nicol,Jinal V Patel,Hannah M Jester et al.
Noelle I Nicol et al.
Accumulating evidence indicates an important role of cyclin-dependent kinases (CDKs) in regulating neuronal function under physiological and pathological conditions. p27Kip1 (p27) is a member of the Cip/Kip family of CDK inhibitors (CKIs) w...
From mild cognitive impairment to normal cognition in Parkinson's disease: The role of brain network architecture [0.03%]
帕金森病从轻度认知障碍到正常认知的变化：脑网络结构的作用
Mattia Siciliano,Rosa De Micco,Maria Agnese Pirozzi et al.
Mattia Siciliano et al.
Introduction: The state of mild cognitive impairment related to Parkinson's disease (PD-MCI) is unstable. However, the mechanisms underlying reversion to normal cognition in patients with early PD-MCI are still not fully ...
Neurotransmitter-associated structural remodeling of the insula-hippocampus mediates cognitive impairment in age-related hearing loss [0.03%]
与年龄相关的听力损失中耳蜗核团结构重塑介导认知障碍发生发展及相关机制研究
Yao Wang,Wenqing Li,Wen Ma et al.
Yao Wang et al.
Age-related hearing loss is a major modifiable risk factor for cognitive decline, yet the dynamic trajectory of brain structural evolution and its underlying neurochemical basis remain poorly understood. This study investigated gray matter ...
Synaptic attenuation by human alpha-synuclein depends on two amino acids in its C-terminal tail [0.03%]
人α-突触核蛋白作用于两个氨基酸及其C端尾长度决定其突触后扣反应
Jen Riba,Liron Samuel,Alexandra Stavsky et al.
Jen Riba et al.
Alpha-synuclein is a protein primarily expressed in the central and peripheral nervous systems that is firmly implicated in Parkinson's disease and other neurodegenerative diseases termed the synucleinopathies. In post-mortem analyses, macr...
Altered physiology and ensemble recruitment of dentate gyrus semilunar granule cells in a mouse model of epilepsy [0.03%]
癫痫小鼠模型海马dentate gyrus回路的神经元招募及神经生理学改变
Laura Dovek,Andrew Huang,Vijayalakshmi Santhakumar
Laura Dovek
The dentate gyrus is a major locus for structural and synaptic reorganization in temporal lobe epilepsy. While physiological changes during epileptogensis are well characterized in the principal dentate projection neuron, granule cells (GCs...
Retinal thinning and dorsal visual stream degeneration in neuronal intranuclear inclusion disease: Multimodal MRI/OCT evidence with network and mediation analyses [0.03%]
神经细胞内包涵体病的视网膜变薄和背侧视觉通路萎缩：多模态MRI/OCT证据及网络和中介分析
Panpan Yuan,Xiaofang Liang,Yi Zhou et al.
Panpan Yuan et al.
Objective: To determine whether retinal thinning in neuronal intranuclear inclusion disease (NIID) is associated with multilevel abnormalities across the visual system and with clinical severity. ...
Rebecka O Serpa,Emily Tufano,James R Connor
Rebecka O Serpa
Parkinson's Disease (PD) is the fastest-growing neurodegenerative disease globally, with prevalence increasing more rapidly than Alzheimer's disease. PD pathogenesis has traditionally been framed around iron accumulation in the substantia n...
A synonymous SLC2A1 variant causes familial epilepsy and paroxysmal exercise-induced dyskinesia by creating aberrant mosaic splicing patterns [0.03%]
SLC2A1同义变异通过产生异常的镶嵌剪接模式导致家族性癫痫和运动诱发性失常
Adam T Higgins,Fiona Wang,William O Pickrell et al.
Adam T Higgins et al.
The glucose transporter type-1 deficiency syndrome (GLUT1-DS) arises from variants in the SLC2A1 gene encoding the glucose transporter type-1 (GLUT1). Genetic analysis of a GLUT1-DS family identified a recurrent heterozygous synonymous SLC2...