Mutation-specific cellular mechanisms in Drosophila models of ATL1-associated hereditary spastic paraplegia [0.03%]
ATL1相关遗传性痉挛性截瘫果蝇模型中的突变特异性细胞机制
Emma Cadoria,Anood Sohail,Breandan N Kennedy et al.
Emma Cadoria et al.
Mutations in ATL1 are a frequent cause of autosomal dominant hereditary spastic paraplegia (HSP), yet patients display a wide range of clinical severity, from slowly progressive "pure" to severe, early-onset "complex" forms. The cellular me...
Seizure-induced apnea causes sudden death independent of cortical spike wave discharge in mouse models of Tuberous Sclerosis Complex [0.03%]
结节性硬化症小鼠模型中，癫痫诱发的呼吸暂停可独立于皮层尖波放电导致突然死亡
Marissa C Incer,Ian C Wenker
Marissa C Incer
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of seizure-related mortality for people with epilepsy (PWE). Current evidence suggests that many cases of SUDEP are due to seizures that produce respiratory arrest, aka seizur...
The Glymphatic system: A key mechanism linking sleep to brain health and diseases [0.03%]
glymphatic系统：连接睡眠和脑健康及疾病的关键机制
Zeyi Yang,Pengtao Li,Rui Yin et al.
Zeyi Yang et al.
Sleep is increasingly recognized as a fundamental regulator of brain homeostasis, yet the mechanisms linking sleep to neurological health have only recently begun to emerge. The glymphatic system, a brain-wide perivascular transport network...
Endocrine and metabolic dysregulation as potential contributors to disease progression in major depressive disorder: Mechanisms and therapeutic implications-A review [0.03%]
内分泌和代谢失调作为重度抑郁障碍进展的潜在影响因素：机制及治疗意义-综述文章
Ee Chang,Yiran Zhu,Wei Wei et al.
Ee Chang et al.
Major depressive disorder (MDD) is one of the leading psychiatric causes of disability worldwide and is characterized by marked heterogeneity, high recurrence risk, and low treatment rates. Traditional models have emphasized monoaminergic n...
Midbrain dopamine loss drives parvalbumin interneuron vulnerability through tissue plasminogen activator-linked perineuronal-net breakdown and hippocampal disinhibition [0.03%]
中脑多巴胺丢失通过组织型纤溶酶原激活剂连接的 periunit 难以分解和海马去抑制驱动结合小核蛋白内侧斜方体神经元脆弱性
Emma Cauzzi,Serena Ficchì,Maria Luisa De Paolis et al.
Emma Cauzzi et al.
Midbrain dopaminergic degeneration is an early feature of Alzheimer's Disease (AD), dementia with Lewy bodies (DLB), and AD-Parkinson's disease overlap (AD-PD). However, its direct contribution to the failure of hippocampal inhibitory-circu...
Iron dyshomeostasis and enhanced myelination in the prefrontal cortex and ventral basal ganglia of a DJ-1 knockout model of early-onset Parkinson's disease [0.03%]
铁代谢紊乱和前额皮质及腹侧纹状体少突胶质细胞增生：DJI基因敲除小鼠帕金森模型研究
Sijie Liu,Wei Chen,Xi Chen et al.
Sijie Liu et al.
Background: Early-onset Parkinson's disease (EOPD) differs from late-onset PD in clinical progression and neurodegenerative patterns. DJ-1 mutations are a known genetic cause of EOPD. Despite the recognized role of iron d...
Single-cell multiome profiling reveals neuronal bias of modulatory role of MeCP2 phosphorylation [0.03%]
单细胞多组学分析揭示MeCP2磷酸化调控神经元偏性
Ziyao Zhang,Xiang Huang,Kalpana Hanthanan Arachchilage et al.
Ziyao Zhang et al.
MeCP2 is subject to many post-translational modifications, such as phosphorylation, in response to diverse stimuli. Several MeCP2 phosphorylation sites have been identified and studied individually. However, the combinatorial effect of phos...
CDKN1A protects medium spiny neurons from Huntington's disease pathology [0.03%]
CDKN1A保护中棘神经元免受亨廷顿舞蹈病病理变化的影响
Seong Won Lee,Trinity J Upshaw,Diandra J Bailey et al.
Seong Won Lee et al.
Huntington's disease (HD) arises from abnormal expansion of CAG trinucleotide repeats within the HTT gene, leading to mutant huntingtin (mHTT) aggregation, progressive loss of striatal medium spiny neurons (MSNs), and progressive neurodegen...
Disruption of the claustrum-ACC pathway contributes to human mind blanking [0.03%]
CLAustum和ACC环路的破坏参与人类心空白状态的产生
Yueyang Cheng,Yixi Zheng,Wei Wang et al.
Yueyang Cheng et al.
The claustrum is a highly connected structure hypothesized to orchestrate conscious experience, yet its role in humans remains enigmatic. To address this question, we prospectively investigated patients with drug-resistant epilepsy who unde...
Loss of immunological control at CD28 superfamily checkpoints links brain and peripheral immunity to depressive-like behaviors in animal models [0.03%]
动物模型中免疫检查点脱靶导致类似抑郁行为的中枢及外周免疫反应失控
Katarzyna Curzytek,Stanisław Malicki,Kinga Kamińska et al.
Katarzyna Curzytek et al.
Interactions between the nervous and immune systems play a central role in depression, yet the mechanisms integrating neuroimmune signaling remain poorly understood. Here, we investigated the regulation of immune checkpoints in three mechan...