RNA-based therapies for neurodegenerative disease: Targeting molecular mechanisms for disease modification [0.03%]
基于RNA的神经退行性疾病疗法：针对疾病的分子机制进行疾病修饰治疗
Vishal Bhati,Sonima Prasad,Atul Kabra
Vishal Bhati
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are characterized by progressive neuronal damage, protein aggregation, and chronic inflammation, leading to cognitive and m...
One nanoparticle delivers two different neuroprotective amino acids into ischemic brain and protects against neuronal death in rat cerebral ischemia injury [0.03%]
一种纳米颗粒携带两种不同的神经保护性氨基酸进入缺血脑组织并保护缺血损伤的脑神经元不受死亡威胁
Jingchen Gao,Xiyuran Wang,Qi Wan
Jingchen Gao
Previous studies have proven that glycine and proline are neuroprotective but have very low permeability through the blood-brain barrier (BBB), which is a major barrier to the application of these neuroprotective amino acids in the therapy ...
Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons [0.03%]
雌二醇通过激活CaMKKβ/AMPK信号通路促进成年感觉神经元轴突生长
Pranav Mishra,Benedict C Albensi,Paul Fernyhough
Pranav Mishra
Adult rat dorsal root ganglion (DRG) sensory neurons express estrogen receptors (ERs) α and β. Estrogen regulates multiple aspects of the nervous system including development, survival, and axonal outgrowth of DRG neurons. While previous ...
Single subanesthetic dose of ketamine exerts antioxidant and antidepressive-like effect in ACTH-induced preclinical model of depression [0.03%]
单次亚麻醉剂量的氯胺酮对ACTH诱导的抑郁症前临床模型表现出抗氧化和抗抑郁作用
Ana Ivanović,Jelena Petrović,Dušanka Stanić et al.
Ana Ivanović et al.
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and oxidative stress represent important mechanisms that have been implicated in etiopathology of depression. Although first antidepressants were introduced in clinical practice...
Olfactory bulb interneurons - The developmental timeline and targeting defined by embryonic neurogenesis [0.03%]
嗅球中间神经元-由胚胎神经发生定义的发育时间线和靶向定位
Natalie J Spence,Eduardo Martin-Lopez,Kimberly Han et al.
Natalie J Spence et al.
The generation of mouse olfactory bulb (OB) interneurons (INs) is initiated in the embryo but continues throughout life. It is generally agreed that OB INs generated postnatally affect the connectivity of the OB, depending on the timeline o...
Exosome-based therapeutics: Advancing drug delivery for neurodegenerative diseases [0.03%]
基于外泌体的治疗：推进神经退行性疾病的药物递送技术
Sakshi Rai,Suman Kumar Ray,Jagat R Kanwar et al.
Sakshi Rai et al.
Neurodegenerative disorders include Parkinson's disease, spinal cord injury, multiple sclerosis and Alzheimer's disease, cause gradual neuronal loss, protein misfolding, and accumulation, resulting in severe cognitive and movement deficits....
GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression [0.03%]
GSK-3β在老化中的调节紊乱：对tau病理和阿尔茨海默病进展的影响
A Rekha,Muhammad Afzal,M Arockia Babu et al.
A Rekha et al.
The role of glycogen synthase kinase-3β (GSK-3β) in the pathogenesis of Alzheimer's disease (AD) is critical for linking amyloid-beta (Aβ) and Tau pathology. The activity of GSK-3β is dysregulated in the regulation of Tau hyperphosphory...
Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions [0.03%]
急性脑皮层损伤中介导单细胞转录变化的介质的探究：对内皮细胞和星形胶质细胞相互作用的见解
Caroline de Jager,Eman Soliman,Michelle H Theus
Caroline de Jager
Traumatic brain injury (TBI) induces complex cellular and molecular changes, challenging recovery and therapeutic development. Although molecular pathways have been implicated in TBI pathology, the cellular specificity of these mechanisms r...
RBM15 relies on m6A modification to inhibit UBE2C, alleviating hippocampal neuronal injury by limiting microglial inflammation [0.03%]
RBM15通过依赖m6A修饰来抑制UBE2C，从而限制小胶质细胞炎症以减轻海马神经元损伤
Yuehong Wan,Qin Kang,Ji Zhang et al.
Yuehong Wan et al.
Background: Microglia are strongly implicated in the development and progression of epilepsy, yet their impact on pathology remains unclear. This study aimed to explore the effects of ubiquitin-conjugating enzyme 2C (UBE2...
P2X7 receptor augments kainic acid-induced nitrosative stress by abrogating GS-HSP25-mediated iNOS inhibition and GSH synthesis in the mouse hippocampus [0.03%]
P2X7受体通过废除GS-HSP25介导的iNOS抑制和GSH合成来增加海马中由喜树酸诱导的过硝基化压力
Ji-Eun Kim,Duk-Shin Lee,Su Hyeon Wang et al.
Ji-Eun Kim et al.
Glutathione (GSH) and heat shock protein 25 (HSP25) reciprocally regulate each other, which maintain redox homeostasis. Since P2X7 receptor (P2X7R) regulates GSH biosynthesis and HSP25 induction, the present study was conducted to explore t...