Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators [0.03%]
成人脑神经可塑性的药理调节：神经肽信号、迷幻剂和突触调质的协同作用
Mustafa M Shokr,Mohamed N Fawzy,Ahmed M Abdelaziz
Mustafa M Shokr
Neuroplasticity refers to the ability of the brain to modify synaptic connections and reorganize neural circuits, underpinning cognitive function, emotional regulation, and recovery from injury. Recent advances have redefined adult neuropla...
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's disease - Mechanisms and therapeutic frontiers [0.03%]
阿尔茨海默病中小胶质细胞衰老与肠道微生物组动态的交织关系——机制和治疗前沿
Akanksha Waghmare,Sandip Rahangadale,Kanchan Khare et al.
Akanksha Waghmare et al.
Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by cognitive impairment and neuronal degeneration, is increasingly recognized as being driven not only by the traditional amyloid-beta and tau pathologies but al...
4-MEC potentially triggers CAV1 via the BDNF-TrkB signaling pathway [0.03%]
4-MEC通过BDNF-TrkB信号通路潜在地触发CAV1
Wangping Zhang,Fangqi Cao,Ming Li et al.
Wangping Zhang et al.
4-Methylethcathinone (4-MEC), a synthetic cathinone with psychostimulant properties, is increasingly abused as a "designer drug". However, its molecular mechanisms, particularly those related to neuroplasticity regulation, remain poorly und...
Irisin regulates mitochondrial function to support synaptogenesis in the developing hippocampus [0.03%]
irisin调节线粒体功能以支持海马发育中的突触发生
Mary R Josten,Kyra N Parker,Crystal Dillon et al.
Mary R Josten et al.
Hippocampal synapse proliferation is a critical period in brain development that demands vast supplies of chemical energy. Maternally derived hormones exert vital effects on mitochondrial function in the developing brain, thus determining n...
Modeling the functional impact of CPEB3 and CPEB4 dysregulation in autism: A theoretical-computational framework [0.03%]
CPEB3和CPEB4失调自闭症的理论-计算模型：功能影响预测框架
Lenin González-Paz,Alejandro Vivas,Arlene Cardozo-Urdaneta et al.
Lenin González-Paz et al.
Autism spectrum disorder (ASD) involves impaired synaptic plasticity tightly coupled to local mRNA translation. Cytoplasmic polyadenylation element-binding proteins 3 and 4 (CPEB3 and CPEB4) are post-transcriptional regulators of neuronal m...
Multi-level computational analysis identifies schizophrenia missense SNPs with implications for synaptic function, neuroimmune dysfunction, and antipsychotic response [0.03%]
多层次的计算分析鉴定精神分裂症错义SNP及其对突触功能、神经免疫功能障碍和抗精神病药物反应的影响
Fatimah M Coppin,Michelle Kwon,Ariya Bakhteri et al.
Fatimah M Coppin et al.
Schizophrenia (SCZ) has strong genetic underpinnings, yet the functional impact of associated genetic variants remains unclear. We computationally analyzed SCZ-associated missense single-nucleotide polymorphisms (SNPs) from the National Hum...
Acute stress uncovers latent β2-adrenergic receptor and Corticotropin Releasing Factor interactions in the ventral Bed Nucleus of the Stria Terminalis critical for long-term stress-avoidance behavior [0.03%]
急性应激在腹侧终纹床核内诱发的β2肾上腺素受体和催乳素释放激素的相互作用是长期应激回避行为的关键因素
Opeyemi Showemimo,Angela E Snyder,Arisha Tariq et al.
Opeyemi Showemimo et al.
β-adrenergic receptor (β-AR) and corticotropin-releasing factor (CRF) regulation of excitatory glutamatergic neurotransmission in the Bed Nucleus of the Stria Terminalis (BNST) is critical for many stress-related behaviors. While β-AR/CR...
Precision therapeutic strategies for Alzheimer's disease: Amyloid β-targeted foundations and multimodal next-generation approaches [0.03%]
阿尔茨海默病的精准治疗策略：β淀粉样蛋白靶向疗法及多模式下一代疗法
Imran Zafar,Muhammad Sohail Khan,Adil Jamal et al.
Imran Zafar et al.
Alzheimer's disease (AD) is the leading cause of dementia and a significant unmet medical challenge, pathologically characterized by amyloid β (Aβ) aggregation, tau hyperphosphorylation, synaptic dysfunction, and chronic neuroinflammation...
The extracellular domain of mGluR6 regulates targeting to the conventional secretion pathway [0.03%]
mGluR6的胞外区调节其向常规分泌途径定位
Andrew P Rideout,Omar W Abuelatta,Melina A Agosto
Andrew P Rideout
In the retina, rod and cone photoreceptors relay information to bipolar cells at glutamatergic synapses. At dendritic tips of ON-type bipolar cells, which depolarize in response to light, the metabotropic glutamate receptor mGluR6 is requir...
Select NSAIDs enhance peripheral nerve growth and calcium signaling through PPARγ activation [0.03%]
选择性非甾体抗炎药通过激活PPARγ促进外周神经的再生及钙信号转导
Jarin Tusnim,Sheetal Padhi,Karl Chelala et al.
Jarin Tusnim et al.
Peripheral nerve injuries (PNIs) are a significant health concern, affecting millions of individuals and resulting in debilitating sensory and motor deficits, as well as severe neuropathic pain. Treatment of PNIs depend on severity and gap ...