Covalent inhibitors in Parkinson's disease: Molecular targeting strategies for neuroprotective intervention [0.03%]
帕金森病的共价抑制剂：神经保护干预的分子靶向策略
Devadharuna Mohan,Raghul Venkatesan,Amarjith Thiyyar Kandy et al.
Devadharuna Mohan et al.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by dopaminergic neuronal loss, protein aggregation, and neuroinflammation. Current symptomatic therapies have not demonstrated disease-modifying effects. Covalen...
Saliha Rizvi,Syed Tasleem Raza,Farzana Mahdi
Saliha Rizvi
Epilepsy is a neurological disorder that shows strong genetic control on the timing and onset of symptoms and drug response variability. Some epilepsy syndromes have clear monogenic mutations but genes with control on the phenotype and seve...
Stable apelin-13 analogues promote cell proliferation, differentiation and protect inflammation induced cell death [0.03%]
稳定的apelin-13类似物可促进细胞增殖、分化并保护炎症诱导的细胞死亡
Priya Sharma,Mary Erazo Bastidas,Usman Ali et al.
Priya Sharma et al.
Emerging evidence indicates that apelin, an adipokine, plays a critical role in numerous biological functions and may hold potential for therapeutic applications; however, its efficacy is constrained by rapid plasma degradation. Thus, the s...
Eprosartan alleviates the traumatic brain injury-induced multi-organ dysfunction syndrome in mice via AT1R/SNS/HMGB1 blockade and PDL-1 modulation [0.03%]
埃プロ沙坦通过AT1R/SNS/HMGB1阻断和PDL-1调节缓解小鼠创伤性脑损伤引起的多器官功能障碍综合征
Manisha Thakur,Sunil Sharma,Neeru Vasudeva et al.
Manisha Thakur et al.
Traumatic brain injury is not constrained only to the brain but delayed secondary events disturb the end organ functioning via intense response of three homeostatic mechanisms such as sympathetic activity, inflammation, and immunosuppressio...
Modulation of Nrf-2/HO-1/HIF-1α/TFAM pathways by Arbutin in rat model of cerebral ischemic stroke [0.03%]
白桦脂醇调控Nrf-2/HO-1/HIF-1α/TFAM信号通路在缺血性脑卒大鼠模型中的作用研究
Pinki Balhara,Sunil Sharma,Neeru Vasudeva et al.
Pinki Balhara et al.
Ischemic stroke (IS) reduces the blood flow to the brain regions that trigger oxidative stress-induced biochemical, behavioural, molecular, and cellular impairments. Current treatment strategies are limited due to their narrow therapeutic w...
Knockout of indoleamine 2,3-dioxygenase 1 gene expression improves depressive and anxiety-like phenotypes in a murine model of mild traumatic brain injury [0.03%]
利用基因敲除技术沉默色氨酸羟化酶1或吲哚胺2，3双加氧酶1基因可改善轻型颅脑损伤小鼠的抑郁和焦虑样行为缺陷的研究闪烁着希望之光
João Luís Vieira Monteiro de Barros,Caroline Amaral Machado,Ricardo Tadeu de Carvalho et al.
João Luís Vieira Monteiro de Barros et al.
Background: Indoleamine 2,3-dioxygenase (IDO) modulates the kynurenine pathway and may influence post-mild traumatic brain injury (mTBI) outcomes. This study tested whether IDO knockout (IDO-KO) mice exhibit distinct beha...
The glymphatic and meningeal lymphatic systems may converge, connecting traumatic brain injury progression with chronic traumatic encephalopathy onset [0.03%]
脑淋巴系统和胶质淋巴系统可能存在关联，这一发现或将创伤性脑损伤与慢性创伤性脑病联系起来
Randy Bent Barker,Eda Karakaya,Didem Baran et al.
Randy Bent Barker et al.
Chronic traumatic encephalopathy (CTE), a progressive neurodegenerative disease marked by perivascular deposition of hyperphosphorylated tau (P-tau), is strongly linked to repetitive concussive traumatic brain injuries (TBIs). Emerging evid...
Ubiquitous calpastatin overexpression in brain-injured mice attenuates motor and cognitive behavioral deficits without overt neuroprotection [0.03%]
脑损伤小鼠中泛在的钙蛋白酶抑制物过表达可减轻运动和认知行为缺陷而没有明显的神经保护作用
Kathleen M Schoch,Dominic N Nthenge-Ngumbau,Jennifer M Brelsfoard et al.
Kathleen M Schoch et al.
Calpains are a family of calcium-dependent cysteine proteases that are activated within the brain minutes after a traumatic brain injury (TBI). Sustained calpain activation contributes to the secondary injury cascade of TBI and has been lin...
DAPK1 induces motor neuron apoptosis in hSOD1G93A-linked amyotrophic lateral sclerosis via regulating the Xiap/JNK pathway [0.03%]
DAPK1通过调节Xiap / JNK途径诱导hSOD1G93A相关肌萎缩侧索硬化症中的运动神经元凋亡
Xiaoli Su,Xingli Tan,Ying Wang et al.
Xiaoli Su et al.
Death-associated protein kinase 1 (DAPK1) is critically involved in regulating cell death in various neurodegenerative disorders. However, the role of DAPK1 in the pathogenesis of amyotrophic lateral sclerosis (ALS) remains unclear. Here, w...
Neuroprotective effect of the peroxisome proliferator-activated receptor γ agonist lobeglitazone following intracerebral hemorrhage in rats [0.03%]
新型PPARγ激动剂洛普格列酮用于防治颅内出血神经系统损伤的疗效及机制研究
Tae Jung Kim,Young-Ju Kim,Soo-Hyun Park et al.
Tae Jung Kim et al.
Lobeglitazone, an oral antidiabetic medication, acts as a peroxisome proliferator-activated receptor γ (PPARγ) agonist and demonstrates neuroprotective effects. This study investigated beneficial effects and mechanisms of lobeglitazone tr...