Orelabrutinib for systemic lupus erythematosus: A randomised, double-blind, placebo-controlled study [0.03%]
奧雷巴替尼治疗系统性红斑狼疮随机、双盲、安慰剂对照研究
Ru Li,Xue Li,Xiaoxia Zhu et al.
Ru Li et al.
Objectives: Orelabrutinib is an oral, highly selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK). Preclinical mechanistic studies have demonstrated its therapeutic potential in systemic lupus erythematosus...
Impacts of HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes singly and combined on autoimmunity, phenotype and comorbidity in patients with Latent Autoimmune Diabetes in the adult. Results from the HUNT and ESTRID studies [0.03%]
成人隐匿性自身免疫糖尿病患者中HLA-DR3/DR4、DR3-DQ2和DR4-DQ8单倍型对自身免疫、表型及共病的影响：HUNT研究与ESTRID研究结果
Elin Pettersen Sørgjerd,Ingrid K Hals,Birte Ee Lønnum et al.
Elin Pettersen Sørgjerd et al.
Background: The major genetic high-risk of developing autoimmune diabetes are HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes. Their importance in Latent Autoimmune Diabetes in Adults (LADA) has only been partly elucidated. Here we ...
Runx3 instructs Aire+ mTEC development, TSA gene expression, and central tolerance [0.03%]
Runx3指令Aire+mTEC发育，TSA基因表达和中枢耐受性
Jun Hyung Sin,Sloan H Phillips,Audrey V Parent et al.
Jun Hyung Sin et al.
The transcription factor Runx3 modulates key gene expression programs important for the development of multiple tissues. Here, we uncover new functions for Runx3 in thymic epithelial lineage development and show Runx3 expression in medullar...
PAD2-mediated citrullination of MBP and early myelin destabilization in multiple sclerosis [0.03%]
PAD2介导的髓鞘碱性蛋白瓜氨酸化及多发性硬化早期髓鞘不稳定性
Nicola Salvatore Orefice,Niels R C Meijns,Emanuele Di Martino et al.
Nicola Salvatore Orefice et al.
Proteins affect most physiological functions in cells and play a key role in maintaining cellular homeostasis. Protein function is tuned at multiple levels, including synthesis and degradation, intracellular localization, and posttranslatio...
Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment [0.03%]
单细胞RNA测序揭示了抗疟药治疗下高多基因风险评分系统性红斑狼疮患者的免疫细胞中持久的I型干扰素表型
Ahmed Sayadi,Maija-Leena Eloranta,Nina Oparina et al.
Ahmed Sayadi et al.
Objectives: Patients with Systemic lupus erythematosus (SLE) who carry a high genetic burden often experience more severe disease. To understand the molecular consequences of polygenic risk, we analyzed single-cell gene e...
Mechanistic studies on the regulation of systemic sclerosis progression by imbalance in angiogenic T cell subsets [0.03%]
血管生成T细胞亚群失衡介导系统性硬化症进展的机制研究
Haomiao Shen,Renli Liu,Haoyang Sun et al.
Haomiao Shen et al.
Vasculopathy is a core pathological feature of systemic sclerosis (SSc), but its immune regulatory mechanisms remain incompletely understood. In particular, the expression patterns, clinical relevance, and functional roles of CD8+CD28- and ...
Machine learning-based cardiovascular risk prediction in systemic lupus erythematosus: development and internal validation of a prognostic model [0.03%]
基于机器学习的系统性红斑狼疮心血管风险预测：预后模型的开发和内部验证
Noémie Benonnier,Marie Robert,Audrey Sousa Alves et al.
Noémie Benonnier et al.
Background: Cardiovascular (CV) diseases are the leading cause of mortality in patients with systemic lupus erythematosus (SLE). While traditional risk factors inadequately assess CV risk, SLE-specific determinants remain...
Endothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome [0.03%]
内皮细胞衍生的尿激酶型纤溶酶原激活物抑制剂-1可促进抗磷脂综合征血栓形成
Yuzhou Gan,Wenying Liang,Chao Liu et al.
Yuzhou Gan et al.
Background: Plasminogen activator inhibitor-1 (PAI-1) plays a key role in modulating fibrinolysis. However, its role in the thrombotic autoimmune disease known as antiphospholipid syndrome (APS) remains understudied. ...
Systemic sclerosis and female reproductive health over lifespan: A systematic review and meta-analysis [0.03%]
系统性硬化病和女性生殖健康：一生的系统评价和荟萃分析
Qi Liu,Xinyi Qiu,Qi Hong et al.
Qi Liu et al.
Background: Systemic sclerosis (SSc) is a rare chronic autoimmune disease that may adversely affect reproductive health. Female SSc patients often face reproductive health challenges. This study aims to systematically ass...
HCV-related cryoglobulinemic vasculitis (mixed cryoglobulinemia syndrome) in the era of direct-acting antivirals: A 10-year experience from Italian tertiary referral centers [0.03%]
直接抗病毒时代意大利三级转诊中心10年HCV相关冷球蛋白血症性血管炎（混合型冷球蛋白血症综合征）经验
Clodoveo Ferri,Marcella Visentini,Caterina Vacchi et al.
Clodoveo Ferri et al.
Objective: To evaluate long-term clinico-serological response to direct-acting antivirals (DAAs) in patients with HCV-related cryoglobulinemic vasculitis (HCV-CV), and to compare the incidence of severe disease complicati...