Crystalline silica exposure of genetically diverse mice exacerbates subclinical autoimmunity into systemic autoimmune disease phenotypes including inflammatory arthritis in female mice [0.03%]
遗传多样的小鼠接触结晶硅可使亚临床自身免疫恶化为包括雌性小鼠的炎性关节炎在内的全身性自身免疫病表型
Lisa M F Janssen,Caroline de Ocampo,Dwight H Kono et al.
Lisa M F Janssen et al.
Inhalation of respirable crystalline silica (c-silica), an occupational hazard, has been associated with the development of systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, it is unclear i...
Itolizumab targets the CD6-ALCAM axis to limit T-cell responses and brain barrier diapedesis in multiple sclerosis [0.03%]
イトリズ马针对CD6-ALCAM轴限制多发性硬化T细胞反应和血脑屏障向胞作用
Cynthia González-Muñoz,Paulien Baeten,Doryssa Hermans et al.
Cynthia González-Muñoz et al.
Background: Genetic and preclinical data highlight CD6 as a promising target for multiple sclerosis (MS), yet the impact of clinically available CD6-targeting treatments on MS immunopathogenesis remains insufficiently def...
Immunomodulatory effects of tacrolimus-loaded lipid-core nanocapsules in autoimmune hepatitis [0.03%]
他克莫司载脂核纳米胶囊在自身免疫性肝炎中免疫调节作用研究
Graziela S Gomes,Cortney Cagle,William Li et al.
Graziela S Gomes et al.
Liver damage in autoimmune hepatitis (AIH) is perpetrated by T-effector lymphocytes that are not adequately restrained by regulatory T cells (Tregs). The goal of AIH treatment is to control inflammation and induce disease remission through ...
Exploration of new biomarkers for rheumatoid arthritis based on plasma proteomics and transcriptome integrated with genome-wide Mendelian randomization [0.03%]
基于血浆蛋白质组和转录组联合全基因范围孟德尔随机化的新类风湿关节炎生物标志物的研究
Peng Zhang,Youbang Liang,Xin Li et al.
Peng Zhang et al.
Objective: Early diagnosis of seronegative rheumatoid arthritis (SNRA) is often challenging due to lack of reliable serological markers. The aim of this study was to explore protein biomarkers of SNRA and identify their p...
Randomized controlled single-center clinical trial of high-intensity interval training in patients with systemic lupus erythematosus [0.03%]
系统性红斑狼疮患者高强度间歇训练的随机对照单中心临床试验
Malte Lund Adamsen,Iben Elmerdahl Rasmussen,Mark Preben Printz Lyngbæk et al.
Malte Lund Adamsen et al.
Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by elevated levels of type 1 interferons (IFN-1). Along with relapses, patients experience persistent fatigue and reduced aerobic capaci...
MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity [0.03%]
补体依赖的细胞毒性试验检测到的抗肌肉特异性激酶抗体以不同的方式影响肌肉特异性激酶信号转导通路这取决于价态和表位特异性
Dana L E Vergoossen,Robyn Verpalen,Stine Marie Jensen et al.
Dana L E Vergoossen et al.
Muscle-specific kinase (MuSK) is a pivotal player in forming and maintaining healthy neuromuscular junctions (NMJ). In MuSK myasthenia gravis (MG), autoantibodies targeting MuSK disrupt its function, impairing neuromuscular transmission and...
Neonatal total parenteral nutrition and the risk of childhood autoimmune diseases: A nationwide population-based study of 2.3 million children [0.03%]
早期全肠外营养与儿童自身免疫性疾病风险的关系：一项针对230万例儿童的全国性队列研究
Tak Kyu Oh,In-Ae Song
Tak Kyu Oh
Background: We evaluated the long-term risk of childhood autoimmune diseases following neonatal total parenteral nutrition (TPN) exposure using a massive nationwide cohort. ...
Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes [0.03%]
自身反应性B细胞通过MHC-I类分子呈递的BCR衍生neo-表位在类风湿关节炎中的作用
Renee van de Wetering,Arieke S B Kampstra,Michel G D Kester et al.
Renee van de Wetering et al.
Somatic mutations can generate neoantigens recognized by CD8+ T cells, enabling targeted elimination of mutated cells. Currently established B cell-targeting therapies in human B cell-mediated autoimmune diseases lack specificity and fail t...
Intermittent fasting ameliorates Sjögren's syndrome-related dry eye through a preponderant bile acid-Akkermansia homeostasis establishment [0.03%]
间歇性禁食通过建立主导胆酸-Akkermansia稳态来缓解Sjögren综合征相关干眼症
Bowen Wang,Wenrui Deng,Kai Liao et al.
Bowen Wang et al.
Intermittent fasting (IF) has emerged as a promising immunometabolic intervention, yet its therapeutic value in Sjögren's syndrome (SS)-related dry eye remains unclear. In this study, IF robustly improved tear secretion and corneal integri...
High-intensity immunosuppression versus modern standard care in poor-prognosis diffuse cutaneous systemic sclerosis: A propensity-matched study [0.03%]
高强度免疫抑制疗法与标准疗法治疗预后不良的弥漫性皮肤系统性硬化病患者的匹配倾向研究
Lucas Khellaf,Rémi Khellaf,Pierre Pinson et al.
Lucas Khellaf et al.
Background: Purpose: The 2023 EULAR update recommends autologous hematopoietic stem-cell transplantation preceded by high-intensity immunosuppression (HI-IS/HSCT) for selected poor-prognosis early diffuse cutaneous system...