A systematic review of abatacept and belatacept in immune-mediated diseases [0.03%]
阿巴西普和贝拉西普在自身免疫性疾病中应用的系统性综述
Alissa M Krek,Dennis D Arnold,Alina C Martin et al.
Alissa M Krek et al.
Background: Abatacept (ABA) and belatacept (BEL) are immunomodulatory fusion proteins in which the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is linked to the Fc fragment of human IgG1. F...
PU.1 drives psoriasis pathogenesis by promoting intermediate monocytes-to-M1 macrophage differentiation through Dectin-1 signaling [0.03%]
PU.1通过Dectin-1信号促进中间型单核细胞向M1巨噬细胞的分化从而驱动银屑病的发生发展
Liping Jin,Shiyao Pei,Liang Dong et al.
Liping Jin et al.
The expansion and pathogenic differentiation of intermediate monocytes (IMs) are critical yet poorly understood events in psoriasis pathogenesis. Here, we identify the transcription factor PU.1 (encoded by SPI1) as a master regulator drivin...
Treatment patterns, disease progression and survival in Sjögren disease-associated interstitial lung disease: a multicentre European cohort study [0.03%]
欧洲多中心队列研究中的舍格伦综合征相关间质性肺病的治疗模式、疾病进展和生存率
Kastriot Kastrati,Marco Sprecher,Florine Weber et al.
Kastriot Kastrati et al.
Background: Interstitial lung disease in Sjögren disease (SjD-ILD) is a clinically relevant and potentially progressive complication, yet treatment remains empirical and poorly supported by evidence. ...
Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility [0.03%]
儿童至成人期体型变化轨迹与类风湿关节炎风险关联的中介作用及代谢不健康、低度炎症的影响和遗传易感性的修饰效应研究
Xing-Yu Wan,Wei Huang,Yi-Xu Wang et al.
Xing-Yu Wan et al.
Objective: To investigate the association between body size changes from childhood to adulthood and rheumatoid arthritis (RA), considering the roles of metabolic unhealthiness, low-grade inflammation, and genetic suscepti...
Urban heat island and risk of rheumatoid arthritis: Insights from genetic predisposition and proteomics [0.03%]
城市热岛与类风湿性关节炎风险的关系：来自遗传易感性和蛋白质组学的见解
Zhenao Zhang,Shunbing Gao,Xue Hu et al.
Zhenao Zhang et al.
Background: Urban heat island (UHI) exposure is an increasingly common consequence of urbanization and climate warming, but its association with rheumatoid arthritis (RA) risk remains unclear. ...
Crystalline silica exposure of genetically diverse mice exacerbates subclinical autoimmunity into systemic autoimmune disease phenotypes including inflammatory arthritis in female mice [0.03%]
遗传多样的小鼠接触结晶硅可使亚临床自身免疫恶化为包括雌性小鼠的炎性关节炎在内的全身性自身免疫病表型
Lisa M F Janssen,Caroline de Ocampo,Dwight H Kono et al.
Lisa M F Janssen et al.
Inhalation of respirable crystalline silica (c-silica), an occupational hazard, has been associated with the development of systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, it is unclear i...
Itolizumab targets the CD6-ALCAM axis to limit T-cell responses and brain barrier diapedesis in multiple sclerosis [0.03%]
イトリズ马针对CD6-ALCAM轴限制多发性硬化T细胞反应和血脑屏障向胞作用
Cynthia González-Muñoz,Paulien Baeten,Doryssa Hermans et al.
Cynthia González-Muñoz et al.
Background: Genetic and preclinical data highlight CD6 as a promising target for multiple sclerosis (MS), yet the impact of clinically available CD6-targeting treatments on MS immunopathogenesis remains insufficiently def...
Immunomodulatory effects of tacrolimus-loaded lipid-core nanocapsules in autoimmune hepatitis [0.03%]
他克莫司载脂核纳米胶囊在自身免疫性肝炎中免疫调节作用研究
Graziela S Gomes,Cortney Cagle,William Li et al.
Graziela S Gomes et al.
Liver damage in autoimmune hepatitis (AIH) is perpetrated by T-effector lymphocytes that are not adequately restrained by regulatory T cells (Tregs). The goal of AIH treatment is to control inflammation and induce disease remission through ...
Exploration of new biomarkers for rheumatoid arthritis based on plasma proteomics and transcriptome integrated with genome-wide Mendelian randomization [0.03%]
基于血浆蛋白质组和转录组联合全基因范围孟德尔随机化的新类风湿关节炎生物标志物的研究
Peng Zhang,Youbang Liang,Xin Li et al.
Peng Zhang et al.
Objective: Early diagnosis of seronegative rheumatoid arthritis (SNRA) is often challenging due to lack of reliable serological markers. The aim of this study was to explore protein biomarkers of SNRA and identify their p...
Randomized controlled single-center clinical trial of high-intensity interval training in patients with systemic lupus erythematosus [0.03%]
系统性红斑狼疮患者高强度间歇训练的随机对照单中心临床试验
Malte Lund Adamsen,Iben Elmerdahl Rasmussen,Mark Preben Printz Lyngbæk et al.
Malte Lund Adamsen et al.
Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by elevated levels of type 1 interferons (IFN-1). Along with relapses, patients experience persistent fatigue and reduced aerobic capaci...