Interventional studies targeting the prodromal or preclinical phase of immune-mediated disease to benefit patient outcomes: a scoping review [0.03%]
针对免疫介导性疾病前驱期或临床前期的干预研究以改善患者预后：综述性文章
Kara Moscovitz,Daivat Bhavsar,Helen Tremlett
Kara Moscovitz
Background: Immune-mediated diseases, including multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and type 1 diabetes (T1D) often progress through prodromal or preclinical phases befo...
Molecular stratification and transcriptome-guided therapeutics in systemic lupus erythematosus with insufficient treatment response [0.03%]
系统性红斑狼疮不足应答患者的分子分层和转录指导治疗
Lorenzo Beretta,Chiu Wai Shirley Chan,Georgia-Savina Moysidou et al.
Lorenzo Beretta et al.
Insufficient treatment response is common in systemic lupus erythematosus (SLE) and may be associated with progressive organ damage, yet the molecular underpinnings of treatment resistance remain elusive. RNA sequencing was performed in blo...
Immunopathogenic role of the HLA-B∗51:01-specific immunopeptidome in Behçet's disease [0.03%]
HLA-B*51:01特异性免疫肽组在贝赫切特病中的免疫病理作用
Yeji Lee,Kyung-Cho Cho,Byung Kyu Cho et al.
Yeji Lee et al.
Objective: The immunopeptidome, the collection of peptides bound to human leukocyte antigens (HLAs), plays a key role in initiating immune responses. HLA-B∗51:01 is an allele associated with Behçet's disease (BD). Howev...
Autoimmunity to mental health: Risk of depression in type 1 diabetes and celiac disease patients - A systematic review, meta-analysis, and bias assessment [0.03%]
自身免疫与心理健康的关系：1型糖尿病和乳糜泻患者抑郁症风险的系统评价、meta分析及偏倚评估
Dagem Desalegn,Simone Fischer,Yeabsira Bedada et al.
Dagem Desalegn et al.
Background: Depression is expected to become the world's largest disease burden by 2030. However, the incidence of depression in individuals with Type 1 diabetes mellitus (T1DM) or Celiac disease (CD) remains poorly studi...
Sera from patients with dermatomyositis and antisynthetase syndrome mediate muscle weakness, impair mitochondrial respiration and induce local cytokine production in muscle tissue [0.03%]
皮肌炎和抗合成酶综合征患者的血清可通过介导肌肉力量下降、影响线粒体呼吸及诱导局部细胞因子产生来损伤肌肉组织
Cecilia Leijding,Stefano Gastaldello,Tomas Schiffer et al.
Cecilia Leijding et al.
Objectives: Idiopathic inflammatory myopathies (IIM) are systemic autoimmune disorders characterized by skeletal muscle weakness and inflammatory cell infiltrates in muscle tissue. Although circulating systemic factors ha...
Deciphering Sjögren's disease: New insights and perspectives extend from advanced omics approaches and immunology [0.03%]
解读舍格伦综合征：先进的组学方法和免疫学提供了新的见解和视角
Hu Chen,Naoki Kaneko,Yukiko Ohyama et al.
Hu Chen et al.
Sjögren's disease (SjD), formerly termed Sjögren's syndrome, is a chronic autoimmune exocrinopathy that has seen substantial advances in basic research over the past decade. Classical experimental approaches have revealed immune dysregula...
Daratumumab monotherapy reverses the immune and pro-fibrotic profiles in refractory lupus nephritis patients: a pilot case study [0.03%]
达雷珠单抗单药治疗难治性狼疮肾炎患者逆转免疫和促纤维化特征：一项病例研究
Dario Roccatello,Alice Barinotti,Massimo Radin et al.
Dario Roccatello et al.
Refractory lupus nephritis (LN) poses a significant clinical challenge in the management of systemic lupus erythematosus (SLE) due to its resistance to conventional immunosuppressive therapies. This study evaluates the immunological, anti-i...
Pathophysiological effects of long COVID-19 (auto)antibodies on fertility [0.03%]
长期COVID-(自体)抗体对生育的病理生理影响
Laura Talamini,Cindy Verdot,Yehuda Shoenfeld et al.
Laura Talamini et al.
Molecular mimicry between foreign and self-antigens has long been recognized to initiate/exacerbate autoimmunity. Shared amino acid sequences have been found between SARS-CoV-2 Spike glycoprotein and human self-proteins, raising concerns ab...
Immune cell-derived cytokines synergistically interact to drive synovial fibroblast invasive function and metabolic capacity [0.03%]
免疫细胞衍生的细胞因子协同作用以驱动滑膜成纤维细胞侵袭功能和代谢能力
Órla Tynan,Alyssa Gilmore,Aenea A I Brugman et al.
Órla Tynan et al.
Rheumatoid Arthritis (RA) is a chronic autoimmune disease, defined by synovial inflammation and joint destruction. A significant proportion of patients still have sub-optimal/no response to current treatments, with recent synovial scRNA-seq...
Proinflammatory CD20+CD3+ T cells as a potential driver of macrophage reprogramming in rheumatoid arthritis [0.03%]
类风湿关节炎中促炎症CD20+CD3+T细胞可能通过重新编程巨噬细胞驱动疾病进展
Suna Jiang,Jiawei Xue,Haonan Jia et al.
Suna Jiang et al.
Objective: CD20+CD3+ T cells, a distinct immune cell population implicated in immune responses, contribute to the development of multiple diseases. However, their role in RA progression, particularly their potential to dr...