Vasculopathy and vasculitis associated with levamisole-adulterated cocaine: a systematic review [0.03%]
利什曼素污染可卡因相关的血管病和血管炎：一项系统性回顾研究
Martin Scoglio,Corinne Orlando,Gregorio P Milani et al.
Martin Scoglio et al.
Objective: Levamisole, once used as anthelminthic or immunomodulator, is now a common cocaine adulterant. It is linked to a systemic vasculopathy/vasculitis. Our purpose was to review its clinical, serological, and histop...
Striatin-3 is a human autoantigen but it is not associated with the S-phase G2 nuclear antigen (SG2NA) staining pattern [0.03%]
striatin-3是人自身抗原但不与S期G2核抗原（SG2NA）染色模式相关
Marvin J Fritzler,Yoshinao Muro,Werner Klotz et al.
Marvin J Fritzler et al.
Human autoantibodies have a long history of being valuable reagents to identify and characterize unique subcellular compartments, macromolecular complexes, and their individual components. One such discovery started as a unique cell-cycle r...
Prior murine neurotropic coronavirus infection ameliorates experimental autoimmune encephalitis [0.03%]
先前的小鼠神經otropic冠狀病毒感染可改善自身免疫性脑炎症状
Divyasha Saxena,Kelly Walter,Elizabeth Amona et al.
Divyasha Saxena et al.
Background: Central nervous system (CNS) infections contribute to the development of neuroinflammation and neurodegenerative diseases. However, the mechanisms underlying the correlation between CNS infection and subsequen...
Alen Zabotti,Lucia Novelli,Michele Maria Luchetti Gentiloni et al.
Alen Zabotti et al.
Interleukin-23 (IL-23) plays a pivotal role in the intricate interplay between the skin, gut, and joints, contributing significantly to the pathogenesis of various inflammatory diseases including psoriasis, psoriatic arthritis (PsA), inflam...
Temporal trajectories and DMARD therapy retention of rheumatoid arthritis patients with different autoimmune and inflammatory comorbidity profiles: a retrospective analysis [0.03%]
具有不同自身免疫和炎症共病谱的类风湿关节炎患者的疾病时间轨迹及DMARD治疗持续性：回顾性分析
Signe Hässler,Julie Aste,Francis Berenbaum et al.
Signe Hässler et al.
Background: Patients with immunological diseases exhibit distinct comorbidity patterns, categorized into low comorbidity, polyautoimmunity, and polyinflammation profiles. This retrospective cohort study aimed to validate ...
Elderly-onset systemic sclerosis defines a distinct clinical subset: analysis from the SPRING registry of the Italian Society for Rheumatology [0.03%]
老年发病的系统性硬化病定义了一种特定的临床亚型：意大利风湿病学会SPRING注册研究分析
Antonio Tonutti,Francesca Motta,Gianluigi Bajocchi et al.
Antonio Tonutti et al.
Objective: Elderly-onset systemic sclerosis (SSc) is relatively uncommon, and its clinical phenotype and prognostic implications remain poorly characterized, with conflicting evidence regarding disease course and outcomes...
Association between age groups and relapse of type 1 autoimmune pancreatitis: a large-scale retrospective cohort study [0.03%]
年龄分层与1型自身免疫性胰腺炎复发的关系：一项大规模回顾性队列研究
Wenfeng Xi,Yunlu Feng,Wen Shi et al.
Wenfeng Xi et al.
Background: Type 1 autoimmune pancreatitis (AIP) is a rare, immune-mediated pancreatic disease prone to relapse. The influence of age on relapse risk remains unclear. This study aimed to determine whether age at diagnosis...
Genetic susceptibility and validation of angiographic patterns in Takayasu arteritis [0.03%]
遗传易感性和胸主动脉炎的血管内造影模式验证
Desiré Casares-Marfil,K Bates Gribbons,Guher Saruhan-Direskeneli et al.
Desiré Casares-Marfil et al.
Background: Prior studies identified subsets of patients with Takayasu arteritis (TAK) based on angiographic patterns of disease in cohorts from India and North America. This study aimed to validate these patterns in a TA...
Alternate splicing converts human CD137 from costimulatory to immunosuppressive function [0.03%]
可变剪接使人类CD137从共刺激转为免疫抑制功能
Manuel Rojas,Luke S Heuer,Weici Zhang et al.
Manuel Rojas et al.
Human membrane-bound CD137 (mCD137) is a well-known costimulatory molecule; however, it is alternatively spliced into two transcripts (sCD137-1, 2) whose function is not yet known. Here, we show that sCD137 isoforms lack the CRD4 region and...
Immune mediated inflammatory disease: T cell engager versus antibody drug conjugate [0.03%]
免疫介导性炎症疾病：双特异性T细胞接头药物与抗体偶联药物的比较
Zhenguo Liang,Hui Xie,Mengyun Mao et al.
Zhenguo Liang et al.
Immune-mediated inflammatory diseases (IMIDs, distinct from IMiDs, immunomodulatory drugs) pose major therapeutic challenges due to complex pathophysiology, limited treatment durability, and associated adverse effects. T cell engagers (TCEs...