Chimeric antigen receptor T cell therapy: a new frontier therapeutic landscape in autoimmune diseases [0.03%]
嵌合抗原受体T细胞治疗在自身免疫性疾病中的前景及挑战
Xueting An,Xiaoyu Huang
Xueting An
Chimeric antigen receptor-T (CAR-T) cells are genetically engineered T cells that has demonstrated significant success in treating hematologic tumors. The therapeutic landscape of CAR-T cell therapy is undergoing paradigm-shifting expansion...
The concept of severity in psoriatic arthritis: a scoping review of the literature [0.03%]
银屑病关节炎严重性的概念：文献综述
Ennio Lubrano,Mauro Fatica,Rubén Queiro et al.
Ennio Lubrano et al.
Objective: The concept of severity in psoriatic arthritis (PsA) remains inconsistently defined, often conflated with disease activity. This scoping review aimed to explore how severity has been defined in the PsA literatu...
Comparative risk of rheumatoid arthritis between glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes [0.03%]
与钠-葡萄糖共转运体2抑制剂相比，胰高血糖素样肽1受体激动剂治疗对2型糖尿病患者类风湿关节炎风险的影响
Fu-Shun Yen,Shiow-Ing Wang,Chii-Min Hwu et al.
Fu-Shun Yen et al.
Introduction: Rheumatoid arthritis (RA) causes disability, chronic pain, and reduced quality of life. Preclinical studies suggest glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce inflammation and protect j...
Evaluation of the mycophenolate mofetil-rituximab combination in systemic sclerosis: a French retrospective multicenter study (MycRiSSc) [0.03%]
法国多中心回顾性研究评估霉酚酸酯利妥昔单抗联合治疗系统性硬化病的效果(MycRiSSc)
François Barde,Kevin Chevalier,Paul Decker et al.
François Barde et al.
Objectives: Mycophenolate mofetil (MMF) and rituximab (RTX) are recommended as first-line therapies for skin and interstitial lung disease (ILD) involvement in systemic sclerosis (SSc). However, data on their combined use...
Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis [0.03%]
基于个体参与者数据的孕期甲状腺过氧化物酶抗体与甲状腺功能关联的解释性研究meta分析
Yindi Liu,Joris A J Osinga,Ulla Feldt-Rasmussen et al.
Yindi Liu et al.
Background: Thyroid peroxidase antibody (TPOAb) positivity is the most important risk factor for hypothyroidism and determines thyroid function follow-up during pregnancy. TPOAb positivity is usually defined by manufactur...
Preliminary safety and efficacy of relmacabtagene autoleucel (relma-cel) in adults with moderately to severely active systemic lupus erythematosus: a phase I dose-escalation study [0.03%]
relmacabtagene autoleucel（relma-cel）治疗中至重度活动性系统性红斑狼疮成人患者的初步安全性和疗效：I 期剂量递增研究
Yiyang Wang,Shaoying Yang,Ye Yu et al.
Yiyang Wang et al.
Background: Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative treatment in autoimmune diseases. Relmacabtagene autoleucel (relma-cel) is an autologous, CD19-directed CAR-T cell product develop...
Treatment outcomes stratified by interferon profile and autoantibodies in rheumatoid arthritis [0.03%]
基于干扰素谱型和自身抗体分层的类风湿性关节炎治疗效果研究
Shoichi Fukui,Tohru Michitsuji,Yushiro Endo et al.
Shoichi Fukui et al.
Despite treatment advances, some rheumatoid arthritis (RA) patients fail to achieve remission with biological/targeted synthetic DMARDs. We prospectively evaluated 200 patients to determine if interferon profiles and autoantibodies predict ...
Methotrexate and low-dose prednisone in idiopathic retroperitoneal fibrosis: a randomised clinical trial [0.03%]
甲氨蝶呤和小剂量泼尼松治疗特发性后腹膜纤维化：随机临床试验
Francesco Peyronel,Alessandra Palmisano,Federica Maritati et al.
Francesco Peyronel et al.
Objectives: To test the efficacy and safety of methotrexate plus low-dose prednisone in patients with idiopathic retroperitoneal fibrosis. Methods: ...
The double-edged sword role of copper in rheumatoid arthritis: Mechanisms, therapeutics, and challenges [0.03%]
铜在类风湿性关节炎中的双刃剑作用：机制、治疗和挑战
Xiao Guan,Zhiyi Huang,Jingrong Chen et al.
Xiao Guan et al.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with an unclear etiology, in which abnormal copper homeostasis has been shown in the blood and synovial fluid of the joints of patients. As an essential trace element in the...
Mitochondrial dysfunction is a potential key mechanism for atherosclerosis predisposition in patients with systemic lupus erythematosus [0.03%]
线粒体功能障碍可能是系统性红斑狼疮患者易患动脉粥样硬化的重要机制
Xinxin Liu,Chao Wang,Xiuru Guan
Xinxin Liu
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and its course is often accompanied by multiple organ damage. The mortality rate of SLE exhibits a "bimodal pattern", namely the early death peak is primarily attributed to...