Ultra-sensitive diagnostic platform utilizing gold nanoparticle integrated in a freestanding hydrogel matrix [0.03%]
一种基于金纳米粒子的独立水凝胶基底的超灵敏检测平台
Omar M Rahman,Shengxi Lan,Andrea M A Pizano et al.
Omar M Rahman et al.
Fluorescence-based analysis for protein detection has been widely adopted; however, they fall short in achieving ultra-sensitive detection because of their inherently low signal-to-noise ratio at sub-picomolar concentrations. To overcome th...
Yevheniia Kharkivska,Olha Shkel,Yun Kyung Kim
Yevheniia Kharkivska
Syntenin is a multifunctional PDZ-domain adaptor protein that orchestrates membrane trafficking, cytoskeletal remodeling, and exosome biogenesis. Initially identified as a syndecan-binding molecule, syntenin has since emerged as a central h...
Nanomaterial-based electrochemical sensors for phenolic antioxidants in foods and beverages: From design to device translation [0.03%]
基于纳米材料的食品和饮料中苯酚类抗氧化剂的电化学传感器：从设计到设备转换
Angga Hermawan,Asmi Aris,Munawar Khalil et al.
Angga Hermawan et al.
Nanomaterial-enabled electrochemical sensors are nearing the performance and practicality needed for routine, on-site monitoring of phenolic compounds in foods and beverages. Advances in nanomaterial dimensionality and hybrid architectures,...
Proteomics method for identifying POT1-associated complexes at telomeres using ChIP-Mass spectrometry [0.03%]
基于质谱的染色质免疫共沉淀技术发现端粒处POT1相关互作蛋白复合物
Nikita Harish Zade,Meghna Jain,Manoj Garg et al.
Nikita Harish Zade et al.
POT1 is the only single stranded telomere binding protein in the shelterin complex. Together with TPP1, POT1 plays a crucial role in regulating telomere length and protecting telomeres from DNA damage repair proteins. The activation of DNA ...
The clinical potential and limitations of metal-organic frameworks (MOFs) in dentistry [0.03%]
金属有机框架（MOF）在牙科的临床潜力和局限性
Wael Sheet Hussein,Ali Fawzi Al-Hussainy,Soumya V Menon et al.
Wael Sheet Hussein et al.
Nanoparticles (NPs) are intentionally incorporated into dental products to enhance material quality. Recently, metal-organic framework (MOF) NPs have attracted significant attention owing to their unique characteristics absent in their larg...
Navigating the frontier of human microglia isolation-standardization and translational insight [0.03%]
人类微胶质细胞分离标准化及转化研究展望
Pankaj Pal,Monika Sharma,Sukesh Kumar Gupta
Pankaj Pal
The expanding field of neuroscience has increasingly recognized the critical role of microglia, the resident immune cells of the central nervous system (CNS), in human health and disease. This review embarks on an in-depth exploration of th...
Rapid and improved surface passivation method for Single-Molecule experiments [0.03%]
单分子实验快速高效的表面包被方法
Alyssa N Gonneville,Alyssa E Ward,Narisa Ria Naidoo et al.
Alyssa N Gonneville et al.
Single-molecule fluorescence experiments are a powerful tool for studying biomolecular interactions, including protein dynamics and oligomerization, protein-protein interactions, and protein-nucleic acid interactions. Biomolecules are commo...
Precision mapping of NF-κB-DNA binding: high-resolution insights via dynamic UV-laser footprinting [0.03%]
高分辨率NF-κB/DNA结合位点的精确定位及动态紫外激光光刻分析的新视角
Imtiaz Nisar Lone,Gözdem Çavdar,Zahari Peshev et al.
Imtiaz Nisar Lone et al.
Sequence-specific binding is at the core of all DNA-templated processes, including the initiation of DNA replication, gene expression and DNA repair. Yet the kinetics and precision of these interactions remain difficult to capture at high r...
Viral-mediated fluorescent labelling of activated hippocampal memory engrams to study epigenetic dynamics associated with gene expression [0.03%]
用于研究与基因表达相关的表观遗传动力学的病毒介导的海马记忆痕迹激活荧光标记方法
Víctor Pola-Véliz,Sebastián B Arredondo,Yennyfer Arancibia et al.
Víctor Pola-Véliz et al.
Memory formation activates a relatively sparse population of engram cells that store long-term memories. Changes in the epigenetic landscape and 3D chromatin architecture have been proposed as key candidate regulators of transcriptional wav...
ERAPID: an end‑to‑end RNA‑seq analysis pipeline for integrative candidate biomarker discovery with applications to neuropsychiatric disorders [0.03%]
ERAPID：一种端到端的RNA测序分析流水线，用于具有神经精神疾病应用的综合候选生物标志物发现
Jihye Park,Seoyeon Youn,Kyuho Kang et al.
Jihye Park et al.
RNA sequencing datasets in the gene expression omnibus (GEO) increasingly include NCBI-generated count matrices, enabling streamlined signature gene discovery. We present ERAPID, a computational framework that automatically processes this p...