Investigation on structure-property relationships of MgO-SrO containing silicate-based bioactive glasses: An experimental and molecular dynamics simulation study [0.03%]
MgO-SrO改性的生物活性硅酸盐玻璃结构性能关系研究：实验与分子动力学模拟结合的方法
Amirhossein Moghanian,Ramin Farmani,Niloufar Kolivand et al.
Amirhossein Moghanian et al.
Molecular dynamics (MD) simulations and experimental analysis were performed on MgO-SrO containing bioactive glasses (MSBGs) with the composition of 60SiO2-(31-x)CaO-4P2O5-5MgO-xSrO (mol%) (x = 0, 1, 3, 5, 8, 10, 15, 20; M5S0-M5S20) to eval...
MDM2/p53-based live-cell quantitative FRET imaging for apoptosis drug discovery [0.03%]
基于MDM2/p53的活细胞定量FRET成像在凋亡药物发现中的应用
Zhiyu Xiao,Lingmin Xie,Ziru Wu et al.
Zhiyu Xiao et al.
Targeting the interaction between P53 and MDM2 to re-activate P53 to induce apoptosis is an important strategy for cancer treatment. In this study, based on the unique advantages of in situ visualization, dynamic imaging, and quantitative a...
Development and characterization of a membrane-permeant GRASP65-mimetic peptide that inhibits Golgi unlinking and cell cycle progression [0.03%]
一种可以渗透膜的GRASP65模拟肽的开发与表征，该肽可抑制高尔基体解离和细胞周期进展
Romina Ines Cervigni,Raffaella Bonavita,Maria Luisa Barretta et al.
Romina Ines Cervigni et al.
The Golgi complex is central to cellular homeostasis and serves as a key processing and sorting hub for protein trafficking. In many cell types, the Golgi complex is organized as interconnected stacks of cisternae, forming a structure known...
Sensitive and specific detection of ctDNA using Copper-Free click chemistry and magnetic bead Technology [0.03%]
基于无铜点击化学和磁珠技术的CTDNA超灵敏超特异检测方法
Reza Didarian,Dilek Kanarya,Sonya Sahin et al.
Reza Didarian et al.
Liquid biopsy, particularly the analysis of circulating tumor DNA (ctDNA), offers immense potential for non-invasive cancer diagnosis and monitoring. It provides a less invasive alternative to traditional tissue biopsies, enabling earlier d...
Fabrication of advanced microneedle-based targeted intravaginal drug delivery devices: therapeutic opportunities and translational challenges [0.03%]
基于微针的靶向宫内药物传输装置的制备：治疗机会和转化挑战
Tejas S Patil,Deepvardhan P Chaudhari,Utkarsh U Bhamare et al.
Tejas S Patil et al.
Millions of women worldwide suffer from a variety of health conditions, including vaginal bacterial and yeast infections, sexually transmitted infections (STIs), urinary tract infections, pelvic inflammatory disorders, and hormonal abnormal...
Explainable machine learning-based prediction of psoriatic arthritis flares using heterogenous real-world data for personalised patient care [0.03%]
基于解释性机器学习的银屑病关节炎发作预测：利用异质真实世界数据进行个性化患者护理
Pradip Moon,Weizi Li,Antoni Chan et al.
Pradip Moon et al.
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterised by unpredictable flare-ups that are difficult to forecast, particularly in patients without an acute phase response. In this paper, we propose and apply an explainabl...
A smoothing method for DNA methylome analysis to enhance epigenomic signature detection in epigenome-wide association studies [0.03%]
一种DNA甲基组分析的平滑方法以增强表观基因组范围关联研究中的表观遗传信号检测
Abderrahim Oussalah,Loris Mousel,David-Alexandre Trégouët et al.
Abderrahim Oussalah et al.
Epigenome-wide association studies (EWAS) are instrumental for mapping DNA methylation changes in human traits and diseases but often suffer from low statistical power and false positives, especially in small cohorts. We developed an EWAS s...
From sample to clinical insight: a review of exome sequencing in disease diagnostics [0.03%]
从样本到临床见解：疾病诊断中外显子组测序的回顾性研究
Gowrang Kasaba Manjunath,Rohit Kumar Verma,Abhijit Berua et al.
Gowrang Kasaba Manjunath et al.
Exome sequencing (ES) has transformed genomic research and clinical diagnostics by enabling precise identification of disease-associated variants within protein-coding regions, which, while representing a minority of the genome, include man...
Toward accurate breast cancer classification: A review of multi-modal machine learning approaches [0.03%]
迈向准确的乳腺癌分类：多模态机器学习方法综述
Archana Mathur,Abbas Mufaddal Dudhiyawala,Sudeepa Roy Dey et al.
Archana Mathur et al.
The innovations in classifying breast cancer into malignant and benign and further categorizing it into molecular subtypes have reshaped healthcare services, enabling accurate diagnosis of the complex conditions. Identification of molecular...
Unravelling cell heterogeneity and gene regulation mechanisms in multiple myeloma through single-cell RNA-seq [0.03%]
利用单细胞RNA测序解析多发性骨髓瘤的细胞异质性和基因调控机制
Jing Jiang,Junlin Xu,Peng Wang et al.
Jing Jiang et al.
Multiple myeloma (MM) is the second most common blood cancer in the world, yet its genetic pathology is not fully understood and MM cells have highly heterogeneous regulatory mechanisms. Single-cell RNA-Sequencing (scRNA-Seq) technologies p...