Molecular structure of the third immunoglobulin domain (Ig3) of human Muscle-Specific kinase (MuSK) [0.03%]
人肌肉特异性激酶(MuSK)的第三个免疫球蛋白结构域(Ig3)的分子结构
Anselmo Canciani,Martina Palamini,Federico Forneris
Anselmo Canciani
The Muscle-Specific Kinase (MuSK) is a monotopic transmembrane receptor responsible for key signaling events during development and maintenance of neuromuscular junctions. The N-terminal extracellular portion of MuSK is characterized by mul...
Targeting Helicobacter pylori thymidylate kinase: structural insights and validation of novel inhibitors [0.03%]
朝向Helicobacter pylori胸苷酸合成酶：结构见解及新型抑制剂的验证
Khushboo Kumari,Faraz Mohd Khan,Meghna Bose et al.
Khushboo Kumari et al.
Thymidine (deoxythymidine triphosphate) plays very important role in DNA synthesis, replication and repair. Therefore, thymidine synthesis pathway enzymes are crucial for the survival of the organism and hence are potent therapeutic targets...
Investigating oncolytic virus M1-Associated vesicles using 3D electron microscopy [0.03%]
基于三维电子显微镜的溶瘤病毒M1蛋白衍生囊泡研究
Lin Nie,Yinyin Li,Deli Song et al.
Lin Nie et al.
The oncolytic virus M1 (OVM) is recognized as an effective and promising oncolytic virus. Extensive research has been conducted to elucidate the molecular mechanisms underlying OVM's selective targeting and destruction of cancer cells. Howe...
Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein [0.03%]
人源弹性蛋白结合蛋白与弹性蛋白肽VGVAPG及乳糖的结合
Zeynep Pinar Haslak,Nicolas Belloy,Laurent Debelle et al.
Zeynep Pinar Haslak et al.
Elastin-derived peptides (EDPs) interact with elastin-binding protein (EBP), a key component of the elastin receptor complex, modulating cellular processes such as protease activation, apoptosis, and chemotaxis via regulation of NEU-1 siali...
Discovery and computational characterization of a novel cryptic pocket in human farnesyl pyrophosphate synthase [0.03%]
人类法尼基焦磷酸合成酶新型隐蔽作用袋的发现与计算表征
Vishal Pandya,Katie A Wilson,Chun Yuen Leung et al.
Vishal Pandya et al.
The mevalonate pathway provides isoprenoid building blocks required for the biosynthesis of more complex downstream products, including cholesterol, as well as for the posttranslational prenylation of membrane-associated proteins. Farnesyl ...
Molecular dynamics simulations refine the pathogenicity of ACVRL1 kinase domain variants by quantifying impacts on ATP binding in pulmonary arterial hypertension [0.03%]
分子动力学模拟通过量化对肺动脉高压ATP结合的影响来精炼ACVRL1激酶域变异的致病性
Irina Borovikova,Igor Uporov,Galina Okhrimenko et al.
Irina Borovikova et al.
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular dia...
An inactive Zika NS2B-NS3pro protease construct for investigating allosteric inhibitors [0.03%]
一种用于探究别构抑制剂的非活性寨卡病毒NS2B-NS3pro蛋白酶结构体
Khac Huy Ngo,Simon Lattmann,Paulina Duhita Anindita et al.
Khac Huy Ngo et al.
The Zika virus protease, composed of the cofactor region from NS2B and the N-terminal region of NS3, plays a critical role in viral polyprotein maturation and represents an attractive therapeutic target. However, developing small-molecule i...
Effects of mineral nutrition on the cuticle structure of Armadillidium vulgare [0.03%]
营养对普通鼠妇甲壳结构的影响
Shunpei Tatsunami,Satoru Okada,Kosuke Yamaguchi et al.
Shunpei Tatsunami et al.
The terrestrial isopod Armadillidium vulgare possesses a hierarchically organized tergite cuticle mineralized with calcium carbonate, comprising crystalline calcite and amorphous calcium carbonate (ACC). In this study, we assessed the effec...
3DDF-VAE: Dual-frequency variational autoencoder with pose-consistency validation for rare cryo-EM conformation discovery [0.03%]
基于姿态一致性的双频变分自编码器用于稀有冷冻电镜构象的发现
Yuanbo Chen,Fuwei Li,Hao Dong et al.
Yuanbo Chen et al.
Revealing the 3D conformational variability of biomolecules is crucial for understanding their function, while cryo-EM reconstruction of rare states remains difficult due to data imbalance and structural detail loss in existing generative m...
Leveraging deep learning semantic segmentation for imaging coral skeletons [0.03%]
利用深度学习语义分割进行珊瑚骨骼影像分析
Alejandra Coronel-Zegarra,Jamie L Knaub,Vivian Merk et al.
Alejandra Coronel-Zegarra et al.
Micro-computed tomography and semantic segmentation provide insights into the structural hierarchy of biomineralized tissues, as exemplified by stony coral skeletons. Non-destructive imaging reveals mechanistic aspects of skeletal growth, i...