Small-scale siRNA screen reveals WWC2 as a novel regulator of cardiomyocyte mitosis [0.03%]
小型siRNA筛选发现WWC2是心肌细胞有丝分裂的新调节因子
Dogacan Yücel,Calvin Smith,Natalia Ferreira de Araujo et al.
Dogacan Yücel et al.
(145): Adult cardiomyocytes exit the cell cycle soon after birth, although this shift can be reversed by molecular interventions. To identify novel regulators of cardiomyocyte proliferation, we performed a comparative transcriptomic analysi...
Soluble epoxide hydrolase deficiency rescues heart failure with preserved ejection fraction by targeting cytochrome P450 2E1 [0.03%]
可溶性环氧合酶缺乏通过靶向细胞色素P450 2E1缓解舒张功能障碍型心力衰竭
Min Zhang,Chen Chen,Xinxing Liu et al.
Min Zhang et al.
Background: Our prior clinical studies established a positive correlation between sEH activity and mortality in heart failure with preserved ejection fraction (HFpEF), the pathophysiological role of the sEH/EET axis in me...
Cardiac fibroblasts-specific USP7 drives post-infarction cardiac fibrosis by deubiquitinating Krüppel-like factor 7 to promote myofibroblast activation [0.03%]
心肌成纤维细胞特异性USP7通过去泛素化Krüppel样因子7促进梗死心脏纤维化中的成纤维细胞向肌成纤维细胞活化转换
Jie Yang,Shaopeng Cheng,Hoshun Chong et al.
Jie Yang et al.
Although cardiac fibroblast-to-myofibroblast transition (FMT) can critically exacerbate collagen deposition and adverse remodeling after myocardial infarction (MI), the underlying regulatory mechanisms remains unclear. While ubiquitin-speci...
Novel angiotensin receptor target as therapy for the diabetic heart: the AT2R [0.03%]
糖尿病心脏治疗的新血管紧张素受体靶点：AT2受体
Mandy Li,Yan Wang,Robert E Widdop
Mandy Li
Diabetic-related heart complications, exemplified by heart failure, represents a growing global health burden, characterised by deterioration of cardiac function, disturbances in cardiac structure such as left ventricular geometry and tissu...
The RNA-binding protein Quaking is essential for cardiac homeostasis and function by regulating Morf4l2 splicing [0.03%]
RNA结合蛋白Quaking通过调节Morf4l2剪接对心脏稳态和功能至关重要
Sunaina Kumari,Shashi,Sandhya Singh et al.
Sunaina Kumari et al.
Background: Lower levels of Qki were reported in human and mouse-failing hearts, implicating its involvement in cardiac diseases. However, the molecular and functional effects of its downregulation in adult myocardium rem...
Slit2-robo signaling regulates angiogenesis and repair following myocardial infarction [0.03%]
slit2-robo信号转导调控心肌梗死后新生血管形成及修复作用
David Wong,Matthew Tran,Julie Martinez et al.
David Wong et al.
The Slit2 guidance ligand and its Roundabout (Robo) family of receptors regulate axonal guidance and vascular patterning during cardiac morphogenesis, yet the role of Slit2-Robo signaling in the adult heart remains unclear. Here, we identif...
Homocysteine activates endothelial TP receptor to promote von Willebrand factor secretion and thrombosis [0.03%]
同型半胱氨酸通过激活内皮TP受体促进von Willebrand因子释放和血栓形成
Jiachen Zhang,Xinyu Jia,Ping Zhu et al.
Jiachen Zhang et al.
Hyperhomocysteinemia (HHcy), characterized by elevated plasma homocysteine (Hcy) levels, is a recognized risk factor for thrombosis and an independent contributor to acute coronary syndrome, although its underlying mechanisms are not fully ...
FABP4, marker of worse prognosis in cardiovascular disease, induces neutrophil's proatherogenic phenotype which is modulated by semaglutide [0.03%]
心力衰竭不良预后的标志物FABP4诱导促动脉粥样化的中性粒细胞表型，该表型可通过索马鲁肽进行调节
David Sánchez-López,David García-Vega,J E Viñuela et al.
David Sánchez-López et al.
Dysfunctional epicardial adiposity is a risk factor for coronary artery disease (CAD). Its genesis is associated with an upregulation of fatty acid binding protein 4 (FABP4) levels, which might exert paracrine inflammatory and atherogenic m...
IGF-1 promotes cell surface expression of HCN4 pacemaker channels contributing to tachycardia [0.03%]
IGF-1促进HCN4起搏通道细胞表面表达导致心动过速
Nadine Erlenhardt,Franziska Wohlfarth,S Erfan Moussavi-Torshizi et al.
Nadine Erlenhardt et al.
Insulin-like growth factor 1 (IGF-1) controls cardiac growth, metabolism, and contractility. Whereas IGF-1 deficiency is associated with cardiovascular risk, the activation of its signal transduction may be cardioprotective after acute myoc...
Molly S Kaissar,Elnaz Ghajar-Rahimi,Adalyn Meeks et al.
Molly S Kaissar et al.
The cardiovascular system adapts to meet rising physiological demands throughout pregnancy. Notably, the left ventricle grows to support this increased workload, which is thought to reverse after delivery. Yet, whether the heart returns to ...