The C-domain of the cerebral dopamine neurotrophic factor (CDNF) is responsible for its cardioprotective activity by binding to the KDEL receptor relocated to the plasma membrane under endoplasmic reticulum stress conditions [0.03%]
脑源性多巴胺神经营养因子的C-端通过与内质网压力条件下载至细胞膜上的KDEL受体结合来发挥其心脏保护作用
Dahienne Ferreira de Oliveira,Leonardo Maciel,Antonio Dos Santos Silva et al.
Dahienne Ferreira de Oliveira et al.
Cerebral dopamine neurotrophic factor (CDNF) has emerged as a key cytoprotective molecule, with well-documented neuroprotective effects in Parkinson's disease models and, more recently, demonstrated cardioprotective properties. In this stud...
DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy [0.03%]
DPP4调节的内皮细胞铁死亡通过铁蛋自噬调控动脉粥样硬化进展
Lanzhuoying Zheng,Ke Liang,Yuanyuan Peng et al.
Lanzhuoying Zheng et al.
Background: Atherosclerosis (AS), the primary pathophysiological foundation of coronary artery disease (CAD), initiates through endothelial dysfunction that facilitates lipid deposition and plaque formation. Emerging evid...
The mineralocorticoid receptor: a new chapter for therapeutic regulation of diabetic cardiomyopathy [0.03%]
盐皮质激素受体：糖尿病心肌病治疗的新篇章
Monica Kanki,Morag J Young
Monica Kanki
Diabetes mellitus is a global health burden and represents a major cause of cardiovascular disease-related morbidity and mortality. Diabetic cardiomyopathy continues to predispose individuals to overt heart failure despite significant advan...
METTL3-dependent N6-methyladenosine modification on LGMN mRNA promotes macrophage ferroptosis and atherosclerosis [0.03%]
METTL3依赖性的LGMN mRNA的N6-甲基腺苷修饰促进巨噬细胞铁死亡和动脉粥样硬化
Yang He,Kaisheng Jiang,Junhong Sun et al.
Yang He et al.
N6-methyladenosine (m6A) modification plays important roles in various biological processes, yet its function in macrophages and its potential link to ferroptosis in promoting atherosclerosis (AS) remain unclear. In this study, elevated lev...
Transcription initiation factor-1A regulates the contraction of vascular smooth muscle and maintains blood pressure [0.03%]
转录起始因子-1A调节血管平滑肌的收缩并维持血压
Xiaolin Yue,Yawei Wang,Zhinan Wu et al.
Xiaolin Yue et al.
Hypertension is a complex condition influenced by many factors. RNA polymerase I (pol I)-specific transcription initiation factor-1A (TIF-1A) regulates ribosome biosynthesis by participating in the formation of a competent pre-initiation co...
Atrial t-tubules adopt a distinct developmental state as Ca2+ handling matures postnatally [0.03%]
心房T小管在出生后Ca2+成熟过程中采用独特的发育状态
C E R Smith,C J Quinn,J D Clarke et al.
C E R Smith et al.
Transverse (t)-tubules ensure a uniform rise in cellular Ca2+ facilitating cardiac contraction. They play a key role in the large mammalian atria (including human) and their loss in heart failure is associated with impaired Ca2+ release. Wh...
AAV-TNNI3 rescues an experimental murine Tnni3 mutation resulting in thin filament mediated DCM [0.03%]
AAV-TNNI3可治疗由TNNI3基因突变导致的肌节病模型小鼠心肌病
Paul J Bushway,Wei Feng,Marina Sampaio De Menezes Cruz et al.
Paul J Bushway et al.
Cardiac thin filament mutations in TNNI3 are associated with up to 3 % of hypertrophic (HCM) cardiomyopathy cases and contribute to severe restrictive (RCM) and dilated (DCM) cardiomyopathy caseloads. As such, thin filament cardiomyopathy m...
Watching the clock: Blood pressure and cardiovascular disease influence circadian machinery in pre-clinical models [0.03%]
看时间：血压和心血管疾病影响预临床模型的生物钟机制
Michelle L Gumz,Sophia A Eikenberry
Michelle L Gumz
Circadian rhythms drive cardiovascular health, and when dysfunctional, disease. Circadian biology rules daily rhythms in physiological mechanisms which allow our bodies to coordinate function with the demands of the external environment. Ho...
Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients [0.03%]
扩张型心肌病患者功能异常的心脏T淋巴细胞的表型和机制研究
Austin Angelotti,Thiruvelselvan Ponnusamy,Vinay Kumar et al.
Austin Angelotti et al.
Background: Dilated cardiomyopathy (DCM) is characterized by increased infiltration and activation of the innate immune system, including neutrophils, monocytes/macrophages, and dendritic cells. However, the phenotypic pr...
Pseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filaments [0.03%]
ACTC1 K326 和 K328 的假乙酰化促进重组人心脏细肌丝的去抑制作用
Kripa Chitre,Olga E Karpicheva,Chloe J King et al.
Kripa Chitre et al.
Electrostatic interactions between actin residues K326 and K328 and tropomyosin bias tropomyosin to an F-actin location where it blocks myosin attachment. K326/328 acetylation neutralizes their charge, potentially disrupting thin filament-b...