Hematopoietic PI3Kγ promotes abdominal aortic aneurysm by orchestrating macrophage trafficking [0.03%]
造血PI3Kγ通过调控巨噬细胞募集促进腹主动脉瘤发生发展
Shuai Liu,Yu Liu,Yacheng Xiong et al.
Shuai Liu et al.
Background and purpose: Abdominal aortic aneurysm (AAA) is characterized by progressive aortic dilation, often driven by chronic inflammation. PI3Kγ, predominantly expressed in myeloid cells, plays a pivotal role in medi...
Myocardial metabolic remodeling in human end-stage ischemic and non-ischemic cardiomyopathy [0.03%]
人类终末期缺血性和非缺血性心肌病中心肌代谢重塑
Hongyi Zhou,Courtney Jayde Christopher,Katarina Jones et al.
Hongyi Zhou et al.
Background: Heart failure (HF) is linked to disturbances in heart metabolism. Metabolomics shows promise in identifying cardiac-specific metabolic changes across different types of heart disease. However, direct compariso...
Sex differences in mitochondrial Ca2+ during ischemia/reperfusion injury: A role for S-Nitrosylation [0.03%]
缺血/再灌注损伤中线粒体Ca2+的性别差异：S-硝基化的作用
Barbara Roman,Courtney E Petersen,Junhui Sun et al.
Barbara Roman et al.
Sex differences in cardiac ischemia/reperfusion (I/R) injury have been reported, but the mechanisms underlying these differences remain poorly understood. As mitochondrial Ca2+ accumulation plays an important role in I/R injury, we examined...
PERK retains a predominantly monomeric state under ER stress conditions [0.03%]
内质网应激条件下 PERK 保持单体状态
Konstantina Georgoula,Luo Liu,Simone Jung et al.
Konstantina Georgoula et al.
The unfolded protein response (UPR) is a central adaptive mechanism that safeguards protein homeostasis in the endoplasmic reticulum (ER). In the heart, UPR signaling contributes to cellular remodeling and survival across a range of patholo...
Tgfbr2 deficiency promotes mitochondrial dysfunction of vascular smooth muscle cells in thoracic aortic aneurysms and dissections [0.03%]
Tgfbr2缺陷通过促进胸主动脉瘤和夹层血管平滑肌细胞线粒体功能障碍发挥作用
Zhenqing Teng,Qi Wang,Yang Zhang et al.
Zhenqing Teng et al.
Mitochondrial dysregulation promotes vascular destabilization through modulation of the phenotypic plasticity of vascular smooth muscle cells (VSMCs) in thoracic aortic aneurysms and dissections (TAADs). Canonical transforming growth factor...
Left and right myocardial ventricular energetics during cardioplegic ischemic arrest and reperfusion in patients undergoing cardiac surgery [0.03%]
心脏手术期间心肌停搏及再灌注时左、右心室能量代谢的改变
Marco Moscarelli,Katie L Skeffington,Daniel Fudulu et al.
Marco Moscarelli et al.
Background: Effective myocardial protection during cardiac surgery is essential, yet the differential metabolic stress of the left (LV) and right ventricles (RV) to ischemia-reperfusion remains poorly characterized. ...
Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis [0.03%]
冠状动脉疾病风险基因PRDM16调节平滑肌稳态
Kunzhe Dong,Yingbing Zuo,Yali Yao et al.
Kunzhe Dong et al.
Objective: Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic switching from a contractile to a synthetic phenotype in vascular diseases such as coronary...
LARP7 promotes postnatal cardiac regeneration by facilitating G2/M phase transition [0.03%]
LARP7通过促进G2/M期转换促进产后心脏再生
Shasha Zhang,Kang Cheng,Junhao Xiong et al.
Shasha Zhang et al.
The limited regenerative potential of adult mammalian cardiomyocyte is the biggest hurdle for the heart repair after injury. La Ribonucleoprotein 7 (LARP7), a member of La ribonucleoprotein domain family, is the key regulator of transcripti...
KCNQ2 downregulation in left stellate ganglion neurons exacerbates malignant ventricular arrhythmias after myocardial infarction [0.03%]
心肌梗死后左侧星状神经节中KCNQ2下调会加重恶性室性心律失常
Ming-Min Zhou,Liao Xu,Di-Zhe Huang et al.
Ming-Min Zhou et al.
Aims: Ventricular arrhythmias (VAs) are a leading cause of sudden cardiac death (SCD) following myocardial infarction (MI), with cardiac sympathetic hyperexcitability serving as a critical trigger. While β-blockers provi...
Corrigendum to "MFN2-mediated decrease in mitochondria-associated endoplasmic reticulum membranes contributes to sunitinib-induced endothelial dysfunction and hypertension/JMCC 10006" [0.03%]
MFN2介导的线粒体相关内质网膜减少参与舒尼替尼诱导的内皮功能障碍和高血压/JMCC 10006的勘误启事
Yao Qu,Zhi-Xue Liu,Xiao-Xu Zheng et al.
Yao Qu et al.