Sodium nitrite improves hypertension-induced myocardial dysfunction by mechanisms involving cardiac S-nitrosylation [0.03%]
钠硝酸盐通过心脏S-亚硝基化机制改善高血压引起的心肌功能障碍
Evandro M Neto-Neves,Lucas C Pinheiro,Renato C Nogueira et al.
Evandro M Neto-Neves et al.
Although nitrite improves vascular function and lowers blood pressure, its cardiac effects are not completely known. We investigated whether nitrite improves the cardiac function in normotensive and in hypertensive rats. Two-kidney, one-cli...
LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction [0.03%]
长链非编码RNA PCFL通过miR-378/GRB2通路促进心梗后的心脏纤维化
Fei Sun,Yuting Zhuang,Haixia Zhu et al.
Fei Sun et al.
Long noncoding RNAs (lncRNAs) are a class of novel molecular regulators in cardiac development and diseases. However, the role of specific lncRNAs in cardiac fibrosis remains to be fully explored. The aim of the present study was to investi...
Alteration in ventricular pressure stimulates cardiac repair and remodeling [0.03%]
心室内压力的改变刺激心脏修复和重塑反应
Kazumasa Unno,Angelos Oikonomopoulos,Yusuke Fujikawa et al.
Kazumasa Unno et al.
The mammalian heart undergoes complex structural and functional remodeling to compensate for stresses such as pressure overload. While studies suggest that, at best, the adult mammalian heart is capable of very limited regeneration arising ...
Matthew S Stratton,Floriana Maria Farina,Leonardo Elia
Matthew S Stratton
Cardiovascular disease remains the number one cause of death and disability worldwide despite significant improvements in diagnosis, prevention, and early intervention efforts. There is an urgent need for improved understanding of cardiovas...
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis [0.03%]
SIRT3活性降低通过钙蛋白酶依赖性破坏ATP合成介导内毒素血症中的心功能障碍
Christoph Koentges,María C Cimolai,Katharina Pfeil et al.
Christoph Koentges et al.
Background: Sepsis-induced cardiomyopathy contributes to the high mortality of septic shock in critically ill patients. Since the underlying mechanisms are incompletely understood, we hypothesized that sepsis-induced impa...
Mechanism of 17β-estradiol stimulated integration of human mesenchymal stem cells in heart tissue [0.03%]
雌二醇刺激的人骨髓间充质干细胞心肌内整合的机制研究
Maria Cristina Mihai,Mirel Adrian Popa,Viorel Iulian Suica et al.
Maria Cristina Mihai et al.
Scarcity of gender specific donor hearts highlights the importance of mesenchymal stem cells (MSCs) as a therapeutic tool for heart repair. However, inefficient incorporation, retention, and activity of MSCs in cardiac tissue remain an obst...
SESN2 protects against doxorubicin-induced cardiomyopathy via rescuing mitophagy and improving mitochondrial function [0.03%]
SESN2通过恢复线粒体自噬和改善线粒体功能来保护心肌免受多柔比星损伤
Panxia Wang,Luping Wang,Jing Lu et al.
Panxia Wang et al.
The clinical application of doxorubicin (Dox) in cancer therapy is limited by its serious cardiotoxicity. Our previous studies and others have recognized that mitochondrial dysfunction is the common feature of Dox-induced cardiotoxicity. Ho...
Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity [0.03%]
从分子和细胞机制层面探讨双叶主动脉瓣以揭示表型异质性
Carmela Rita Balistreri,Elena Cavarretta,Sebastiano Sciarretta et al.
Carmela Rita Balistreri et al.
High-fat diet improves tolerance to myocardial ischemia by delaying normalization of intracellular PH at reperfusion [0.03%]
高脂饮食通过延缓再灌注时细胞内pH值的正常化来改善心肌缺血耐受性
Javier Inserte,David Aluja,Ignasi Barba et al.
Javier Inserte et al.
Reports on the effect of obesity on the myocardial tolerance to ischemia are contradictory. We have described that obesity induced by high-fat diet (HFD) reduces infarct size in B6D2F1 mice submitted to transient coronary occlusion. In this...
Erratum to "Epigenetic regulation of cardiac cell cycle Re-entry and proliferation" [Journal of Molecular and Cellular Cardiology 121C (2018) 297-299] [0.03%]
关于“心脏细胞周期再启动和增殖的表观遗传调控”一文的勘误通知
Inna Rabinovich-Nikitin,Rimpy Dhingra,Lorrie A Kirshenbaum
Inna Rabinovich-Nikitin