Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome [0.03%]
沙利唑坦对人乙醇胺受体通道的强抑制作用，沙利唑坦是一种用于雷特综合征的 investigational疗法
Hongwei Cheng,Chunyun Du,Yihong Zhang et al.
Hongwei Cheng et al.
Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of the cardiac QTc interval. QTc prolongation calls for cautious use of drugs with a ...
Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes [0.03%]
动态棕榈酰化调节心肌细胞多种亚细胞室之间K通道互作蛋白2(KChIP2)的转运
Akshay Murthy,Samuel W Workman,Min Jiang et al.
Akshay Murthy et al.
Background: K channel interacting protein 2 (KChIP2), initially cloned as Kv4 channel modulator, is a multi-tasking protein. In addition to modulating several cardiac ion channels at the plasma membrane, it can also modul...
Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression [0.03%]
Wnt1通过促进ANKH表达抑制血管平滑肌细胞钙化
Beidong Chen,Yang Zhao,Duanyang Han et al.
Beidong Chen et al.
Aims: Wnt signaling plays a critical role in vascular calcification (VC). Wnt factors induce different physiological and pathological effects on cardiovascular functions. Wnt1, a ligand of Wnt/β-catenin signaling, promot...
Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis [0.03%]
幽门螺杆菌感染的胃上皮细胞来源的外泌体CagA诱导巨噬细胞泡沫细胞形成并促进动脉粥样硬化形成
Shuai Yang,Yuan-Peng Xia,Xue-Ying Luo et al.
Shuai Yang et al.
Background: Seroepidemiological studies have highlighted a positive relation between CagA-positive Helicobacter pylori (H. pylori), atherosclerosis and related clinic events. However, this link has not been well validated...
Patterns of ascending aortic dilatation and predictors of surgical replacement of the aorta: A comparison of bicuspid and tricuspid aortic valve patients over eight years of follow-up [0.03%]
主动脉扩张的发展模式和手术替换主动脉的预测因素——8年随访的双叶和三叶主动脉瓣患者的比较研究
Valentina Agnese,Salvatore Pasta,Hector I Michelena et al.
Valentina Agnese et al.
Background: Predictors of thoracic aorta growth and early cardiac surgery in patients with bicuspid aortic valve are undefined. Our aim was to identify predictors of ascending aorta dilatation and cardiac surgery in patie...
Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia/reperfusion injury [0.03%]
SUMOylation对心肌缺血/再灌注损伤关键蛋白的作用及机制
Jingwen Chen,Yuanyuan Luo,Shuai Wang et al.
Jingwen Chen et al.
Myocardial ischemia/reperfusion (MI/R) injury has a great influence on the prognosis of patients with acute coronary occlusion. The underlying mechanisms of MI/R injury are complex. While the incidence of MI/R injury is increasing every yea...
Remodeling of substrate consumption in the murine sTAC model of heart failure [0.03%]
小鼠心力衰竭sTAC模型底物利用的重建
Aslan Turer,Francisco Altamirano,Gabriele G Schiattarella et al.
Aslan Turer et al.
Background: Energy metabolism and substrate selection are key aspects of correct myocardial mechanical function. Myocardial preference for oxidizable substrates changes in both hypertrophy and in overt failure. Previous w...
MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels [0.03%]
微小核糖核酸1976通过靶向Cav1.2和Cav1.3离子通道调节窦房结退行性变
Jin Zhang,Feiyu Wei,Liqun Ding et al.
Jin Zhang et al.
Sick sinus syndrome (SSS) is primarily a disease of the elderly, and age-dependent decrease in Cav1.2 and Cav1.3 Ca2+ channels within the sinus node has been shown to play an important role in sinoatrial node (SAN) degeneration; however, po...
Heat shock protein inducer GGA*-59 reverses contractile and structural remodeling via restoration of the microtubule network in experimental Atrial Fibrillation [0.03%]
热休克蛋白诱导剂GGA*-59通过恢复实验性房颤中的微管网络逆转心肌重构
Xu Hu,Jin Li,Denise M S van Marion et al.
Xu Hu et al.
Background: Atrial Fibrillation (AF) is the most common progressive tachyarrhythmia. AF progression is driven by abnormalities in electrical impulse formation and contractile function due to structural remodeling of cardi...
Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition [0.03%]
smooth muscle特异性TMEM16A表达通过抑制细胞外基质沉积保护机体免于血管紧张素II诱导的脑血管重塑
Xue-Lin Zeng,Lu Sun,Hua-Qing Zheng et al.
Xue-Lin Zeng et al.
Cerebrovascular remodeling is the leading factor for stroke and characterized by increased extracellular matrix deposition, migration and proliferation of vascular smooth muscle cells, and inhibition of their apoptosis. TMEM16A is an import...