The mechanistic of DCBLD2 in inhibiting TGF-β induced endothelial-mesenchymal transition in calcific aortic valve disease [0.03%]
DCBLD2在抑制TGF-β诱导的主动脉瓣钙化病血管细胞间质转化中的作用机制研究
Weiwei Yang,Qi Feng,Chao Yu et al.
Weiwei Yang et al.
Objective: Despite significant elevations in the morbidity and mortality of calcific aortic valve disease (CAVD), no effective pharmacological treatments are currently available. This study aimed to elucidate the regulato...
Thin filament interaction and Ca2+-desensitization effect of the C-terminal end peptide of cardiac troponin T and loss of function in hypertrophic cardiomyopathy mutants [0.03%]
心肌病突变体心脏TnT C端短肽的相互作用及Ca2+脱敏效应和功能丧失研究
Qiaobin Li,Han-Zhong Feng,J-P Jin
Qiaobin Li
Troponin T (TnT), the tropomyosin (Tm)-binding subunit of troponin, plays a central role in regulating striated muscle contractility. The recently identified Tm-binding site 3 in the highly conserved C-terminal end segment of TnT has a trop...
Silencing PACS2 attenuates cardiac hypertrophy by inhibiting ferroptosis via activating SIRT1 [0.03%]
PACS2的沉默通过激活SIRT1来抑制铁死亡从而缓解心室肥大
Zhijie Shen,Yinzhuang Zhang,Li Fang
Zhijie Shen
Background: Cardiac hypertrophy plays an important role in organ damage caused by hypertension and may progress into heart failure. This study investigated the function and underlying mechanisms of phosphofurin acidic clu...
Integrated single-cell multi-omics analysis identifies fibroblast-like smooth muscle cells as a key driving phenotypic switching during aortic aneurysm progression [0.03%]
整合单细胞多组学分析鉴定出纤维样平滑肌细胞在主动脉瘤发生发展过程中驱动表型转换中的关键作用
Jianlin Zhang,Wenbo Zhao
Jianlin Zhang
Background: Aortic aneurysm (AA) is a life-threatening vascular disorder characterized by smooth muscle cell (SMC) phenotypic switching. However, SMC heterogeneity and the regulatory mechanisms underlying this transition ...
TRPM8-dependent protective effects of L-menthol attenuates lipid overload-induced calcium dysregulation and mitochondrial dysfunction in mouse ventricular myocytes [0.03%]
L-薄荷醇的TRPM8依赖性保护作用可减轻脂质过载诱导的小鼠心室肌细胞钙稳态失调和线粒体功能障碍
Xiang Sun,Qirui Ding,Yuyan Zhou et al.
Xiang Sun et al.
Cardiac injury from lipid overload features cardiomyocyte death, myocardial remodeling, and reduced contractile function. Although L-menthol has reported cardioprotective effects, its mechanisms are poorly defined. We therefore examined the...
Heartbeats and hidden codes: Decoding cardiac aging with multi-omics and computational approaches [0.03%]
心跳与隐藏代码：利用组学和计算方法解码心脏衰老
Smin L Liu,Li Qian
Smin L Liu
Aging is a major risk factor for cardiovascular disease, yet the mechanisms driving age-related cardiac decline remain incompletely defined. Although traditional omics approaches have identified global signatures of inflammation and metabol...
Restoration of mitochondrial Ca2+ and redox homeostasis by enhancement of SK channels rescues Ca2+ cycling in HFpEF cardiomyocytes [0.03%]
通过增强SK通道恢复心力衰竭伴随保留射血分数的心肌细胞线粒体Ca2+和抗氧化稳态以修复Ca2+循环
Shanna Hamilton,Radmila Terentyeva,Roland Veress et al.
Shanna Hamilton et al.
Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases. In addition to diastolic dysfunction, patients with HFpEF have a substantial risk of sudden cardiac death, suggesting a potential co...
Loss of phospholamban phosphorylation blunts Ca2+ handling during the cellular adrenergic response [0.03%]
磷酸化心磷脂蛋白丢失对细胞肾上腺素反应过程中Ca2+调控的影响
Achal M Gowda,Holden T Rogers,Erick B Ríos Pérez et al.
Achal M Gowda et al.
Adrenergic stimulation modulates excitation-contraction coupling (ECC) and cardiac function primarily through protein kinase A (PKA), which phosphorylates multiple ECC proteins. Key PKA targets include phospholamban (PLB), a critical regula...
Novel enhancer activation non-restrictively followed a predefined framework in plastic vascular smooth muscle cells [0.03%]
新型增强子在血管平滑肌细胞中的激活不受预定义框架的限制
Chao Yu,Jiaxin Huang,Xiaocheng Zhang et al.
Chao Yu et al.
Differentiated cells such as the plastic vascular smooth muscle cells (SMCs) could continue to develop after birth, mediated by continuously expanded enhancer network. However, it still remains unclear whether the adult enhancer network exp...
Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells [0.03%]
石蒜碱盐酸盐通过MAPK介导的平滑肌细胞表型转化预防内膜增生的作用机制研究
Dongxu Li,Li Li,Yingying Fan et al.
Dongxu Li et al.
Neointimal hyperplasia results from irregular vascular smooth muscle cell (VSMC) proliferation and migration. Lycorine hydrochloride (LH), known for its cardioprotective properties, was investigated for its impact on neointimal hyperplasia ...