Mesenchymal Stem Cell Differentiation Induced by Lyophilized PRP During Early Osteogenesis [0.03%]
富血小板血浆冻干粉诱导间充质干细胞早期成骨分化方向的研究
Marcel Rodrigues Ferreira,Geórgia da Silva Feltran,Anderson Moreira Gomes et al.
Marcel Rodrigues Ferreira et al.
Platelet-rich plasma (PRP) contains a complex mixture of growth factors, cytokines, chemokines, miRNAs, hormones and ions that can modulate early reparative events, yet its effects on osteoblastic commitment remain unclear. We examined the ...
Targeted Deletion of EPHX2 in Intestinal Epithelial Cells Alleviates DSS-Induced Colitis by Enhancing Goblet Cell Differentiation [0.03%]
肠上皮细胞EPHX2基因缺失通过促进杯状细胞分化缓解DSS诱导的结肠炎
Jiuheng Yin,Duoli Zhang,Hongxiang Zeng et al.
Jiuheng Yin et al.
Dysregulation of epoxide hydrolase 2 (EPHX2) is associated with the pathogenesis of various diseases. However, the functional role of EPHX2 in ulcerative colitis remains unclear. In this study, we demonstrate that EPHX2 plays a critical r...
Sodium Tanshinone IIA Sulfonate Ameliorates Fibrosis of Skeletal Muscle Injury by Regulating Transforming Growth Factor-β1/Smad3 and Phosphoinositide 3-Kinase/protein Kinase B/Cyclooxygenase-2 Signaling Pathways [0.03%]
丹参素钠通过调节转化生长因子-β1/Smad3和磷脂酰肌醇3激酶/蛋白激酶B/环氧化酶-2信号通路改善骨骼肌损伤纤维化
Fujun Ding,Jinghai Gong,Fei Yu et al.
Fujun Ding et al.
Sodium tanshinone IIA sulfonate exerts several pharmacological effects; however, its mechanism in skeletal muscle injuries remains unknown. We explored the biological function of sodium tanshinone IIA sulfonate in skeletal muscle injury and...
The Interaction of PELP1 With FHL2 Contributes to Ectopic Endometrial Stromal Cell Proliferation, Angiogenesis, and Inflammation in Endometriosis [0.03%]
PELP1与FHL2的相互作用促进子宫内膜异位症病灶成纤维细胞增殖、血管生成及炎症反应
Yanmei Cheng,Shiwei Li,Lei Zhao et al.
Yanmei Cheng et al.
Endometriosis (EMS), a multifactorial and chronic benign gynecological disease characterized by ectopic endometrial growth, remains poorly understood in its pathogenesis. Proline, glutamic acid, leucine-rich protein 1 (PELP1), implicated in...
Insight Into the Cellular Activities of Tranexamic Acid as an Option for Melasma Treatment [0.03%]
透析氨甲环酸作为治疗黄褐斑的一种选择的细胞活性研究见解
Yekatsiaryna Hushcha,Anna Lisa Giuliani,Martini Fernanda et al.
Yekatsiaryna Hushcha et al.
Melasma and other hyperpigmentation disorders represent a significant challenge in dermatology. Tranexamic acid (TXA), traditionally known for its antifibrinolytic activity via inhibition of plasminogen activation, has recently emerged as a...
Biochanin A Attenuates Renal Fibrosis Via Selective Inhibition of Smad3-mediated Epithelial-Mesenchymal Transition in a Murine Unilateral Ureteral Obstruction Model [0.03%]
生物活性化合物抑制Smad3介导的上皮间质转化从而减轻肾纤维化的作用及机制研究
Huai-Ying Guo,Yu-Qing Li,Cong Wei et al.
Huai-Ying Guo et al.
Renal fibrosis driven by TGF-β/Smad3 signaling is a critical factor in the advancement of chronic kidney disease, and partial epithelial-to-mesenchymal transition (EMT) in tubular cells plays a significant role in this process. In this stu...
Oroxin A Induces Autophagic Cell Death in Gastric Cancer Cells Through the MAPK/ERK/REDD1 Axis [0.03%]
Oroxin A通过MAPK/ERK/REDD1轴诱导胃癌细胞自噬性死亡
Linen Li,Jianfang Rong,Foqiang Liao et al.
Linen Li et al.
Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, with limited treatment efficacy and high drug resistance. Natural compounds offer promising therapeutic potential due to their multitarget and low-toxicity profile...
Novel Insights Into Small Open Reading Frame-Encoded Micropeptides in Glioblastoma [0.03%]
胶质母细胞瘤中小开放阅读框编码微肽的新见解
Meiru Wang,Shuangshuang Pan,Jiaze Meng et al.
Meiru Wang et al.
Glioblastoma is the most aggressive type of brain tumor, with a dismal prognosis, highlighting the urgent need for novel biomarkers and therapeutic targets. Recent advances in transcriptomics and proteomics have revealed the critical role o...
Synergistic Reduction of Breast Cancer Cell Viability and Aggressiveness Through Dual Inhibition of APE1 Redox Function and STAT3 Signaling [0.03%]
通过APE1氧化还原功能和STAT3信号的双重抑制协同降低乳腺癌细胞活力和侵袭性
Mariana Moreno de Sousa Rodrigues,Priscyanne Barreto Siqueira,Ana Clara Cavallo Dobao et al.
Mariana Moreno de Sousa Rodrigues et al.
Aggressiveness and resistance to treatments are significant problems in cancer management. In this scenario, searching for new pharmacological targets for therapies is essential. The APE1 redox domain coactivates transcription factors that ...
Delta- and Gamma-Tocotrienols Inhibit the Proliferation of HCC2998 Human Colorectal Carcinoma Cells via Modulation of Histone Modification Pathways Involved in DNA Damage Response [0.03%]
脱辅基维生素E通过调节DNA损伤反应中的组蛋白修饰途径抑制HCC2998人类结直肠癌细胞增殖
Ali Qusay Khalid,Saatheeyavaane Bhuvanendran,Kasthuri Bai Magalingam et al.
Ali Qusay Khalid et al.
Colorectal cancer (CRC) remains a significant global health burden, necessitating the exploration of novel therapeutic strategies. Tocotrienols (T3s), particularly gamma (γ)- and delta (δ)-T3 isoforms, exhibit promising anticancer propert...