Delta- and Gamma-Tocotrienols Inhibit the Proliferation of HCC2998 Human Colorectal Carcinoma Cells via Modulation of Histone Modification Pathways Involved in DNA Damage Response [0.03%]
脱辅基维生素E通过调节DNA损伤反应中的组蛋白修饰途径抑制HCC2998人类结直肠癌细胞增殖
Ali Qusay Khalid,Saatheeyavaane Bhuvanendran,Kasthuri Bai Magalingam et al.
Ali Qusay Khalid et al.
Colorectal cancer (CRC) remains a significant global health burden, necessitating the exploration of novel therapeutic strategies. Tocotrienols (T3s), particularly gamma (γ)- and delta (δ)-T3 isoforms, exhibit promising anticancer propert...
Bufalin-Induced Epithelial-to-Mesenchymal Transition in Kidney Epithelial Cells [0.03%]
黄芩素诱导的肾脏上皮细胞间质转化
Gabriela Morais de Oliveira Barros,Kayo M Bagri,Claudia Mermelstein et al.
Gabriela Morais de Oliveira Barros et al.
The kidney plays a central role in fluid, electrolyte, and blood pressure regulation, processes tightly coupled to Na⁺/K⁺-ATPase activity. Beyond its canonical transport function, Na⁺/K⁺-ATPase also acts as a signaling receptor for card...
Establishment, Characterization, and Cryopreservation of Feather Follicle Fibroblast Lines From Hyacinth Macaw (Anodorhynchus hyacinthinus) [0.03%]
蓝金凤鹦鹉(Anodorhynchus hyacinthinus)羽毛囊成纤维细胞系的建立、鉴定和冻存
Iara Pastor Martins Nogueira,Rachel Castro Teixeira-Santos,Gustavo Caldeira Cotta et al.
Iara Pastor Martins Nogueira et al.
Cryopreservation, biobanking, and in vitro propagation of cells from endangered species represent key strategies for advancing biodiversity conservation. The Hyacinth Macaw (Anodorhynchus hyacinthinus), a flagship avian species of the Brazi...
Esculetin Attenuates Doxorubicin-Induced Cardiotoxicity via Modulation of Apoptotic and Mitochondrial Gene Expression Networks [0.03%]
Esculetin通过调节凋亡和线粒体基因表达网络来缓解多柔比星引起的心脏毒性
Yeliz Demir,Hamid Ceylan,Medine Sibel Karağaç et al.
Yeliz Demir et al.
Doxorubicin (DOX), although widely used as a potent chemotherapeutic agent, is limited by its dose-dependent cardiotoxicity. Esculetin (E), a naturally occurring coumarin derivative, has been reported to exert antioxidant and anti-apoptotic...
Vinpocetine Overcomes Paclitaxel Resistance in a Triple-Negative Breast Cancer Cell Line [0.03%]
长春花碱克服三阴性乳腺癌细胞系中的紫杉醇耐药性
Hsiao-Hui Kuo,Chien-Wei Huang,Wei-Rou Chiang et al.
Hsiao-Hui Kuo et al.
Paclitaxel is a first-line treatment for triple-negative breast cancer (TNBC), but its efficacy is commonly limited by tumor-cell resistance. Vinpocetine is a well-tolerated dietary supplement with pleiotropic cellular effects, including po...
Matter of Fat: Cancer-Associated Adipocytes as Mediators of Tumor Progression and Immune Evasion [0.03%]
肿瘤相关脂肪细胞在肿瘤进展和免疫逃逸中的作用
Niti Sureka,Shikhar Chohan,Samreen Zaheer et al.
Niti Sureka et al.
Peritumoral adipocytes that exhibit changes in their phenotype and distinct biological characteristics, such as reduced expression of mature adipocyte differentiation markers, increased secretion of adipocyte-derived factors, and facilitati...
Takuro Toda,Tsuyoshi Hirota
Takuro Toda
The circadian clock generates 24-h molecular rhythms through transcription-translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep-wake cycles, body temperature, hormone secretion, metabolism, a...
Cytogenotoxic Evaluation of Lercanidipine Hydrochloride in Human Lymphocytes Using Micronucleus, Chromosome Abnormalities, and Molecular Docking Assays [0.03%]
微核、染色体异常和分子对接测定法在人淋巴细胞中评估氯苯唑地平氢氯化物的细胞遗传毒性评价
İbrahim Halil Kenger,Ahmet Kardöl,Ahmet Kayraldiz et al.
İbrahim Halil Kenger et al.
This study evaluated the cytotoxic and genotoxic potential of lercanidipine hydrochloride (LHC) on human peripheral lymphocytes using in vitro and in silico approaches. The micronucleus (MN) test revealed a significant, dose-dependent incre...
Tauroursodeoxycholic Acid Mitigates Inflammation, ER Stress, and Apoptosis in Experimental Endotoxin-Induced Uveitis: In Vivo and In Vitro Evidence [0.03%]
tau-ursodioxycholic酸通过体内和体外证据缓解内毒素诱导的实验性葡萄膜炎中的炎症、内质网应激和凋亡
Yusuf Samet Atlıhan,Aleyna Öztüzün Ün,Hazal Tuzcu Balaban et al.
Yusuf Samet Atlıhan et al.
Endotoxin-induced uveitis (EIU) is a well-established model for acute ocular inflammation and mimics aspects of human uveitis. Tauroursodeoxycholic acid (TUDCA), a bile acid with known anti-inflammatory and cytoprotective properties, may at...
Gene Editing for Cystic Fibrosis: Advances and Prospects of CRISPR-Cas9 Therapy [0.03%]
囊性纤维化疾病的基因编辑进展及CRISPR-Cas9治疗展望
Iqra Khurram,Mahmood S Choudhery,Muhammad Usman Ghani et al.
Iqra Khurram et al.
Cystic fibrosis (CF) is an inherited, autosomal recessive disorder that is caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CFTR maintains the balance between water and salts by transporti...