Detection of Injury-Associated Protein Using a MIF Antibody in Physarum polycephalum and Badhamia utricularis [0.03%]
利用MIF抗体检测Physarum polycephalum和Badhamia utricularis中与损伤相关的蛋白质
Killian Menuet,Janice de Almeida Engler,Christine Coustau
Killian Menuet
Myxomycetes are remarkable organisms, capable of strikingly complex behaviors and exceptional wound healing, yet the molecular mechanisms underlying their immunity and regenerative capacities remain largely unexplored. In this study, we pro...
Antimetastatic Effects of Thymoquinone in Colorectal Cancer: Targeting Cell Adhesion, Migration, and Invasion in SW480 and SW620 Models [0.03%]
愈创木quinone抗转移作用的产生是通过在SW480和SW620模型中抑制细胞黏附、迁移与侵袭作用来实现的
Mouna Selmi,Abir Salek,Mahassen Barboura et al.
Mouna Selmi et al.
Thymoquinone (TQ), the major bioactive constituent of Nigella sativa, Asian and African medicinal plant, has attracted growing interest for its anticancer properties. In this study, we investigated the antimetastatic potential of TQ in huma...
Human Fidgetin Modulates Cell Migration and EMT in Breast Cancer Cells [0.03%]
人源FIDGETIN通过调节乳腺癌细胞迁移和上皮间质转化发挥促癌作用
Suranjana Mukherjee,Jyotirmoy Chatterjee
Suranjana Mukherjee
Epithelial-mesenchymal transition (EMT) and cell migration are two essential cellular processes involved in normal biological events such as embryogenesis, organ development, and wound healing, and are also associated with pathological cond...
Glutathione and TRPM2 Inhibition Reduce Amyloid-Beta and Lipopolysaccharide-Induced Apoptosis, Inflammation, and Oxidative Stress in Microglial Cells [0.03%]
谷胱甘肽和瞬时受体电位锚定通道2抑制剂可减少淀粉样蛋白-β和脂多糖诱导的小胶质细胞凋亡、炎症及氧化应激
Orhan Akpınar,Mustafa Nazıroğlu
Orhan Akpınar
Microglia cells impacted by inflammation and Alzheimer's disease produce toxic reactive oxygen species (ROS), emit signaling molecules, and death as a result of microglia being active due to excessive Ca2+ entering the cells. The TRPM2 chan...
Applications and Complementarity of Organ-Chips and Animal Models in Lung Cancer Driver Gene Research [0.03%]
器官芯片与动物模型在肺癌驱动基因研究中的应用和互补性
Lu-Kai Wang,Tsai-Jung Wu,Fu-Ming Tsai
Lu-Kai Wang
Alterations in driver genes in lung cancer, such as those in EGFR, KRAS, EML4-ALK, and TP53, play pivotal roles in tumor progression, therapeutic response, and resistance development. Therefore, it is important to develop research models th...
Mesenchymal Stem Cells With Pharmacological Combinations Necessary to Maximize Retinal Photoreceptor, Outer and Inner Nuclear Layers Rescue [0.03%]
药物联合治疗优化视网膜神经节细胞系修复视网膜光感受器和内外核层损伤的研究
Girish K Srivastava,Amar K Singh
Girish K Srivastava
The rising prevalence of retinal diseases underscores the need for personalized neuroprotection strategies. Mesenchymal stem cells (MSCs) exhibit paracrine neuroprotective potential and are used clinically when transplantation is unnecessar...
Effects of Histone Deacetylases (HDACs) in Programmed Cell Death: Execution Mechanism and Regulatory Pathways [0.03%]
组蛋白去乙酰酶（HDAC）在程序性细胞死亡中的作用：执行机制与调节途径
Qi Wu,Yingjie Zhao,Qiuxia Yu et al.
Qi Wu et al.
Histone deacetylases (HDACs) are zinc- or NAD + -dependent enzymes that play a key role in controlling diverse cellular processes by removing acetyl groups from the lysine residues of both histone and nonhistone proteins. In humans, there a...
Transplantation of Macrophages Pretreated With Gingival Mesenchymal Stem Cell Conditioned Medium as a Potential Cell Therapy for Promoting Periodontal Tissue Regeneration in Rats With Experimental Periodontitis [0.03%]
经牙龈间充质干细胞培养基预处理的巨噬细胞移植作为促进实验性牙周炎大鼠牙周组织再生的潜在细胞疗法
Meng Liu,Xiaotong Wang,Haowen Zhou et al.
Meng Liu et al.
Periodontitis is caused by the interaction between dental plaque and various risk factors, leading to the pathological loss of periodontal tissues. However, the traditional methods for periodontitis treatment is insufficient for controlling...
The Role of Sphingomyelin Synthase 2 in Lipid Metabolism and Its Implications in Diseases [0.03%]
鞘氨醇单磷酸脂合成酶2在脂代谢中的作用及其疾病意义
Leihuan Sun,Jiayi Wang,Leiliang Zhang
Leihuan Sun
Sphingomyelin synthase 2 (SMS2) is a crucial enzyme predominantly localized to the plasma membrane, playing an essential role in sphingomyelin metabolism and signaling. SMS2 catalyzes the final step in the biosynthesis of sphingomyelin by t...
Never in Mitosis Gene A-Related Kinase Inhibition Alleviates Inflammation in an In Vivo Model of Acute Lung Injury [0.03%]
无丝分裂基因A相关激酶抑制剂缓解急性肺损伤小鼠模型的炎症反应
Saikat Fakir,Md Matiur Rahman Sarker,Nektarios Barabutis
Saikat Fakir
Chronic lung inflammation affects alveolar-capillary permeability and results in impaired gas exchange which may lead to edema, acute lung injury, and acute respiratory distress syndrome. The serine/threonine kinase NEK2, a member of the NI...