FAM117B Promotes Colorectal Cancer Progression by Enhancing DYRK1A-mediated Phosphorylation of PLK2 [0.03%]
FAM117B通过增强DYRK1A介导的PLK2磷酸化促进结直肠癌进展
Zhige Yu,Chen Zhou,Hongxi Chen et al.
Zhige Yu et al.
Among solid tumors, colorectal cancer (CRC) ranks as one of the most frequently diagnosed. This study aimed to investigate the role and underlying mechanism of family with sequence similarity 117 member B (FAM117B) in CRC. Western blotting ...
Slingshot Phosphatase and LIM Kinase Modulate Mast Cell Activation Beyond the Regulation of Actin Dynamics [0.03%]
肌动蛋白动力学调节之外的弹簧夹磷酸酶和LIM激酶调控肥大细胞活化
Ruriko Suzuki,Satoru Yokawa,Naohide Hirashima et al.
Ruriko Suzuki et al.
Slingshot (SSH) phosphatase and LIM kinase (LIMK) regulate actin dynamics through the dephosphorylation and phosphorylation of cofilin, an actin-severing protein. Antigen stimulation rapidly and temporally induces cofilin dephosphorylation ...
PTPRE Exacerbates Phenotypic Transformation of Vascular Smooth Muscle Cells and Vasomotor Dysfunction in Salt-Sensitive Hypertension [0.03%]
PTPRE通过促进血管平滑肌表型转化加重盐敏感性高血压患者的血管运动功能障碍
Shi-Cheng Li,Hao Wang,Qiao-Yu Shao et al.
Shi-Cheng Li et al.
Prior studies have identified atypical expression of protein tyrosine phosphatase receptor type E (PTPRE) in animal models of salt-sensitive hypertension (SSH). This study investigates PTPRE's role in SSH and clarifies its mechanism of acti...
The Crosstalk of Epithelial Cells, Endothelial Cells, and Macrophages Orchestrates Inflammation in Chronic Obstructive Pulmonary Disease [0.03%]
上皮细胞、内皮细胞和巨噬细胞的相互作用调控慢性阻塞性肺疾病的炎症反应
Yanqin Qin,Jingfan Yang,Yuwei Song et al.
Yanqin Qin et al.
Inflammation is associated with disease progression and frequent exacerbations of chronic obstructive pulmonary disease (COPD). The cell crosstalk plays a central role in initiating and maintaining inflammation. This study aimed to establis...
LRRC8A Mediates Ischemic Neuronal Injury by Potentiating NMDA Receptor Activity and Activating Mitochondrial Apoptotic Pathway [0.03%]
LRRC8A通过增强N-甲基-D天冬氨酸受体活性和激活线粒体凋亡途径介导缺血性神经元损伤
Chengli Qian,Linshu Huang,Ying Chen et al.
Chengli Qian et al.
Brain ischemia induces neuronal apoptosis, a key event in stroke pathology, but the underlying mechanisms remain incompletely understood. This study investigates the role of the volume-regulated anion channel subunit leucine-rich repeat-con...
GATA3-NLRP1 Axis Inhibits Hepatocellular Carcinoma Progression Through the Hedgehog Signaling [0.03%]
GATA3-NLRP1轴通过Hedgehog信号通路抑制肝癌进展
Dong Sun,Xu Sun,Jiazi Zhang et al.
Dong Sun et al.
As a member of the inflammasome, NLRP1 has been reported to play roles in some cancers. However, the effect of NLRP1 in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the effect and mechanism of NLRP1 on HCC. The...
Pharmacological Inhibition of NF-κB in Mesenchymal Stromal Cells Selectively Partitions Apoptosis-Inducing Factors in Their Microvesicles and Proliferation-Inducing Factors in Their Exosomes: Implications in the Management of Acute Myeloid Leukemia [0.03%]
NF-κB的药理学抑制选择性地将凋亡诱导因子分区到间充质基质细胞的微泡中，将增殖诱导因子分区到其外泌体中：对急性髓系白血病管理的意义
Shalmali Pendse,Sayali Chavan,Vishakha Kasherwal et al.
Shalmali Pendse et al.
We previously showed that inhibition of the NF-κB signaling pathway in mesenchymal stromal cells (MSCs) (NKI-MSCs) induces quiescence in co-cultured hematopoietic stem cells (HSCs). This led us to investigate whether NKI-MSCs exert similar...
Strongyloides Antigens Alter Cytokines Responses in Toxoplasma gondii-Infected BeWo Trophoblast Cells [0.03%]
Strongyloides抗原改变Toxoplasma gondii感染的BeWo滋养细胞的细胞因子反应
Fabíola Teixeira Alves,Bhrenda Carolliny Guardieiro Jesus,Maria Eduarda Silva Diniz et al.
Fabíola Teixeira Alves et al.
The importance of co-infections is not yet completely understood, and the impact and direction of their effects vary considerably. This study aimed to evaluate the role of total saline extract (TS) and excretory/secretory (ES) products of S...
Nanocarriers of Fertility: Mesenchymal Stem Cell-Derived Exosomes in Male Reproductive Repair [0.03%]
生育纳米载体：间充质干细胞来源的外泌体在男性生殖修复中的作用
Danial Mahrooghi,Morteza Abdi,Farzin Soleimanzadeh et al.
Danial Mahrooghi et al.
Male infertility is a multifactorial condition affecting approximately 8%-12% of reproductive-age couples worldwide, with male factors contributing to nearly half of all cases. Traditional treatments often offer limited efficacy, especially...
Unravelling Mechanisms of Cancer Cells' Tropism for Metastasis: A Key to Improved Cancer Therapies [0.03%]
阐明癌细胞转移趋向性机制：提高癌症治疗效果的关键
Sumit Mallick,Jahnvi Hora,T K Varun et al.
Sumit Mallick et al.
Selective migration of tumors to particular organs, referred to as organ tropism, is not arbitrary but guided by intricate molecular interactions and a complex network of various secretory molecules. This site-specific migration is modulate...