Engineering Immortalized Bovine Granulosa Cells Using a Triple-Gene Approach: Mutant CDK4, Cyclin D1, and TERT [0.03%]
利用三重基因工程使牛颗粒细胞永生化：突变CDK4、cyclinD1和TERT
Lanlan Bai,Minami Takahashi,Jin Kobayashi et al.
Lanlan Bai et al.
Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine gran...
m6A-Mediated IGF1 Hypomethylation Impairs Decidualization and Promotes Preeclampsia Pathogenesis: Implications for Epigenetic Therapy [0.03%]
通过mRNA m6A修饰调节IGF1表达治疗子痫前期的机制研究
Jing Tong,Xingyun Yan,Cong Zhang
Jing Tong
The decidua, a dynamic and heterogeneous maternal tissue essential for pregnancy maintenance, has emerged as a key contributor to preeclampsia (PE) pathogenesis. Using methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequen...
Solute Carrier Family 19 Member 1 Mediates Acquired Bortezomib Resistance in Multiple Myeloma Through Chronic Stimulator of Interferon Genes Activation and Mitochondrial DNA Release [0.03%]
慢性刺激干扰素基因激活和线粒体DNA释放介导的成瘾博莱霉索多发性骨髓瘤耐药的溶质载体家族19成员1的作用机制研究
Yixuan Chen,Xianyi Wu,Mingxuan Tang et al.
Yixuan Chen et al.
Acquired drug resistance is a major cause of poor prognosis in multiple myeloma (MM). Bortezomib (BTZ), a first-line therapeutic agent, is highly effective in MM; however, resistance remains a significant clinical challenge. Our previous wo...
The miR-148/152 Family Suppresses Apoptosis and Necroptosis for Cancer Evasion Through Direct RIPK1 Repression [0.03%]
微RNA家族成员miR-148/152通过直接抑制RIPK1来抑制凋亡和坏死性凋亡以促进癌细胞逃逸
Jingjing Li,Qiuye Li,Yuting Ji et al.
Jingjing Li et al.
Evasion of programmed cell death, including apoptosis and necroptosis, is a critical hallmark of cancer that contributes to tumorigenesis and chemoresistance. While microRNAs (miRNAs) are known to modulate cell death pathways, the role of s...
Tetrachlorobisphenol A Induces Programmed Cell Death and Senescence in Vascular Endothelial Cells [0.03%]
四氯化双酚A诱导血管内皮细胞程序性坏死和衰老
Huanyu Qiao,Bo Yang,Xiaoshuo Lv et al.
Huanyu Qiao et al.
Tetrachlorobisphenol A (TCBPA) is an organic compound extensively utilized in industrial production as an alternative to Tetrabromobisphenol A (TBBPA). Currently, TCBPA has been frequently detected in various environmental media. TCBPA resi...
CD44 N-Glycosylation Alleviates Myocardial Ischemia-Reperfusion Through PI3K/AKT/mTOR Pathway [0.03%]
CD44 N-糖基化通过PI3K / AKT / mTOR途径缓解心肌缺血再灌注损伤
Yanxin Ren,Haibin Dong,Qingwen Huang et al.
Yanxin Ren et al.
Myocardial ischemia-reperfusion injury (MIRI) is one of the leading causes of morbidity and mortality from cardiovascular diseases worldwide. Protein N-glycosylation plays an important role in MIRI. However, there is limited knowledge regar...
RETRACTION: CXCR4-Positive Cell-Derived Pdx1-High/Shh-Low Cells Originated From Embryonic Stem Cells Improve the Repair of Pancreatic Injury in Mice [0.03%]
撤回：来源于胚胎干细胞的CXCR4阳性细胞衍生的Pdx1高/Shh低细胞改善小鼠胰腺损伤修复
T. Yu, Q. Qing, N. Deng, X.-H. Min, L.-N. Zhao, J.-Y. Li, Z.-S. Xia and Q.-k. Chen, "CXCR4-Positive Cell-Derived Pdx1-High/Shh-Low Cells Originated From Embryonic Stem Cells Improve the Repair of Pancreatic Injury in Mice," Cell Biology Int...
Overexpression of Gopc Promotes Cardiomyocyte Proliferation but Delays Overall Heart Regeneration in Zebrafish [0.03%]
Gopc过表达促进斑马鱼心肌细胞增殖但延缓心脏整体再生
Junying Gao,Pengchong Zhang,Long Zhao
Junying Gao
The adult mammalian heart exhibits minimal regenerative capacity as cardiomyocytes are quiescent, whereas the adult zebrafish robustly regenerates injured myocardium. Understanding the mechanisms of this natural cardiac regeneration capacit...
Protective Role of the EGR1-Nudt16L1 Pathway in Spermatogonial Stem Cells Against Testicular Ischemia-Reperfusion Injury [0.03%]
EGR1-Nudt16L1信号通路通过抑制DNA损伤及炎症反应保护生精干细胞免于睾丸缺血再灌注损伤
Yiming Weng,Yanqiu Wang,Jun Xiang et al.
Yiming Weng et al.
Spermatogonial stem cells (SSCs) are essential for maintaining sperm production but are highly susceptible to damage from testicular ischemia-reperfusion (IR) injury, a common consequence of conditions like testicular torsion. This injury l...
Interleukin-17A-Producing Gamma Delta T Cells Accelerate Mineralization in Human Dental Pulp Stem Cells [0.03%]
产生IL-17A的γδT细胞加速人牙髓干细胞矿化作用
Tomoki Kumagai,Satoru Shindo,Katsuhiro Takeda et al.
Tomoki Kumagai et al.
γδ T cells, which express the T cell receptor γδ, contribute to both innate and adaptive immune responses, yet their role in dental pulp pathology remains poorly understood. This study investigated the impact of γδ T cells on the calc...