PKMYT1/FOXM1/Snail Axis Promotes Metastasis in Clear Cell Renal Cell Carcinoma by Inducing Epithelial-mesenchymal Transition [0.03%]
PKMYT1/FOXM1/Snail轴通过诱导上皮间质转化促进透明细胞肾细胞癌的转移
Jianzhi Su,Ren Xu,Bin Liu et al.
Jianzhi Su et al.
Clear cell renal cell carcinoma (ccRCC), the most prevalent subtype of renal cell carcinoma, exhibits high invasiveness and metastatic potential. Membrane-associated tyrosine/threonine 1 (PKMYT1) is linked to poor prognosis in ccRCC; howeve...
Melatonin Relieves Neuropathic Pain and Depressive-Like Behaviors by Inhibiting the ERK/NF-κB/c-Fos Signaling Pathway in the Spinal Cord of Spared Nerve Injury Mice [0.03%]
褪黑素通过抑制损伤神经支配小鼠脊髓ERK/NF-κB/c-Fos信号通路缓解神经病理性疼痛及抑郁样行为
Shuang Wang,Yuanxun Liu,Shaohui Chen et al.
Shuang Wang et al.
Neuropathic pain (NP) is marked by ongoing nociceptive signals and accompanied by symptoms resembling depression, which complicates treatment strategies. Melatonin (MT), a hormone known for its neuroprotective properties, has garnered atten...
Brucine as a Natural Modulator of Cancer Signaling: Cellular Mechanisms, Therapeutic Potential, and Translational Perspectives [0.03%]
布鲁辛作为癌症信号的天然调节剂：细胞机制、治疗潜力和转化前景
Putri Cahaya Situmorang,Helen Helen,Rony Abdi Syahputra et al.
Putri Cahaya Situmorang et al.
Brucine (BRU), a naturally occurring indole alkaloid primarily derived from Strychnos nux-vomica, has recently gained attention for its notable anticancer potential. Preclinical studies using both in vitro and in vivo models have demonstrat...
Research Progress on the Antagonism of Aluminum-Induced Neurotoxicity by Ginsenosides [0.03%]
人参皂苷拮抗铝致神经毒性的研究进展
Lu Zhihang,Lu Jiaxu,Ye Zhao et al.
Lu Zhihang et al.
Aluminum (Al) was a nonessential toxic metal in the environment. Al exposure had been widely demonstrated to cause cognitive impairment and neuronal damage. However, the neurotoxicology mechanism of Al was still not summarized through the o...
Potential of Micronuclear Epigenetic Signatures in Analyses of Toxicity and Genomic Instability [0.03%]
微核表观遗传特征在毒性及基因组不稳定性分析中的潜力
Somnath Paul,Ankita Das,Apurba K Bandyopadhyay et al.
Somnath Paul et al.
Micronuclei (MN) are small extranuclear chromosomal fragments that arise from genomic instability and serve as established biomarkers for genotoxicity and disease susceptibility. Once considered only markers of disease, they are now recogni...
Advances in Antibacterial, Anti-Biofouling, and Corrosion-Resistant Surface Technologies [0.03%]
抗菌、防生物污染和耐腐蚀表面技术进展
Anca Mazare,Wolfgang H Goldmann,Alexander B Tesler
Anca Mazare
This commentary provides a comprehensive and forward-looking analysis of biofouling and the development of antifouling technologies. It culminates in two innovative, non-toxic approaches: aerophilic surfaces and liquid-infused slippery surf...
Orchestrating Microtubules: A Review of Kinase-Dependent Regulatory Mechanisms [0.03%]
蛋白激酶调控微管装配的机制综述
Yaqian Zhang,Shasha Hua,Kai Jiang
Yaqian Zhang
Microtubules are subject to dynamic regulation through post-translational modifications, with phosphorylation serving as a key mechanism. The human kinome, comprising over 500 protein kinases, represents a comprehensive regulatory network. ...
RFC4 Promotes the Metastasis of Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway [0.03%]
RFC4通过调控Wnt/β-catenin信号通路促进结直肠癌转移
Guansheng Hu,Laiai Fang,Xiang Ding et al.
Guansheng Hu et al.
Replication factor C (RFC), a multimeric protein with ATPase activity, plays a crucial role in DNA replication and repair. RFC4, one of its subunits, is aberrantly expressed in various malignant tumors, including colorectal cancer (CRC). Ne...
RETRACTION: Autophagy Regulates the Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells Under Hypoxic Condition via AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway [0.03%]
撤稿：自噬通过AMP活化蛋白激酶/哺乳动物雷帕霉素靶蛋白信号通路调节缺氧条件下骨髓间充质干细胞的凋亡
Z. Zhang, M. Yang, Y. Wang, L. Wang, Z. Jin, L. Ding, L. Zhang, L. Zhang, W. Jiang, G. Gao, J. Yang, B. Lu, F. Cao, and T. Hu, "Autophagy Regulates the Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells Under Hypoxic Condition via AMP-...