NPC2 Regulates Glioblastoma Cholesterol Metabolism and Malignant Behavior via GPX4-Linked Ferroptosis [0.03%]
NPC2通过GPX4连接的铁死亡调节胶质母细胞瘤胆固醇代谢和恶性行为
Wei Jiang,Wei Wang,Junping Wang et al.
Wei Jiang et al.
Glioblastoma (GBM) is a highly aggressive intracranial malignancy originating from neuroepithelial glial progenitors. The prominent intra- and intertumoral heterogeneity of GBM is a major driver of therapeutic resistance and frequent tumor ...
Icariin as a Modulator of Cancer Cell Biology: Integrated Control of Proliferation, Cell Death Programs, Metastasis Signaling, and Delivery Challenges [0.03%]
淫羊藿黄素在癌症细胞生物学中的作用及其面临的挑战：整合调控增殖、细胞死亡程序、转移信号及递送问题
Putri Cahaya Situmorang,Cheryl Grace Pratiwi Rumahorbo,Alexander Patera Nugraha et al.
Putri Cahaya Situmorang et al.
Icariin, a prenylated flavonoid derived from plants of the Epimedium genus, has attracted increasing attention due to its broad spectrum of pharmacological activities, particularly its anticancer potential. Accumulating evidence indicates t...
Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors [0.03%]
temporal lysophosphatidic acid 补充可增强人造血祖细胞巨核细胞的分化和血小板生成
Nittaya Jiamvoraphong,Chanchao Lorthongpanich,Praphasri Septham et al.
Nittaya Jiamvoraphong et al.
Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non-genetic and cost-effective system...
Karyopherin Subunit Alpha 3 Drives Temozolomide Resistance in Glioblastoma by Upregulating MGMT and Activating STAT3 to Sustain Glioma Stem Cells [0.03%]
核转运受体家族成员KPNA3通过上调MGMT和激活STAT3来维持胶质瘤干细胞而导致胶质母细胞瘤对替莫唑胺产生抗性
Yanru Gao,He Yuan,Houling Zhou et al.
Yanru Gao et al.
Glioblastoma (GBM) invariably develops resistance to temozolomide (TMZ), the frontline chemotherapeutic agent, leading to treatment failure. The molecular mechanisms underlying this resistance remain incompletely understood. Here, we identi...
RPL27 Promotes Gastric Cancer Progression by Enhancing Oxidative Phosphorylation Via FMC1 [0.03%]
RPL27通过FMC1促进氧化磷酸化从而促进胃癌发展
Yan Zheng,Yuhui Ye,Yang Cheng et al.
Yan Zheng et al.
Gastric cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for novel biomarkers and therapeutic targets. Ribosomal proteins have recently emerged as critical regulators of tumorigenesis beyond...
Preliminary Insights Into the Combined Antitumor Efficacy of Onco-VV-TT and Natural Killer Cells in Glioblastoma [0.03%]
Onco-VV-TT和自然杀伤细胞联合治疗胶质母细胞瘤的初步观察
Seyedeh Nasim Mirbahari,Davood Sanooghi,Marzieh Ebrahimi et al.
Seyedeh Nasim Mirbahari et al.
This study investigates the therapeutic efficacy and safety of Onco-VV-TT, a genetically engineered oncolytic vaccinia virus, in the treatment of glioblastoma (GBM), with and without the combination of natural killer (NK) cell immunotherapy...
Chemical Reprogramming of Fibroblasts to Functional Mammary Epithelial Cells via a Single BMP Inhibitor [0.03%]
单一BMP抑制剂化学重编程纤维母细胞为功能型乳腺上皮细胞
Quanhui Liu,Dandan Zhang,Guodong Wang et al.
Quanhui Liu et al.
Direct lineage reprogramming offers a highly promising non-genetic pathway for generating functional somatic cells. In this study, a single small molecule inhibitor of the BMP pathway, LDN193189, was able to directly reprogram goat ear fibr...
Vitamin B6 Ameliorates Lipopolysaccharide-Induced Inflammation in Mouse Gastric Organoids [0.03%]
维生素B6改善小鼠胃器官芯片的脂多糖诱导炎症反应
Aoqing Xu,Yijin Wu,Xiyu Wang et al.
Aoqing Xu et al.
Gastric mucosal inflammation is a critical precondition of various gastric diseases, and development of safe and effective anti-inflammatory agents for prompt resolution of acute inflammation at early stage is vital to preventive medicine. ...
Cell Line-Specific In Vitro Effects of Boric Acid and Meis1i-2 in Leukemia Cells: Apoptosis, Cell-Cycle Modulation, and Fixed-Dose Interaction [0.03%]
硼酸和Meis1i-2对白血病细胞系的体外效应：细胞系特异性的凋亡、细胞周期调节以及固定剂量相互作用
Neslihan Meriç,Aynura Mammadova,Fatih Kocabaş et al.
Neslihan Meriç et al.
Leukemia, a hematological malignancy resulting from genetic mutations and environmental factors, leads to uncontrolled proliferation and impaired differentiation of hematopoietic cells. Current treatment modalities face limitations such as ...
Picrosides I and II Ameliorate Steatosis by Modulating Lipogenesis, Mitochondrial Biogenesis, and Autophagy in Hepatic Cells [0.03%]
鼠李毒肽I和II通过调节肝细胞脂质生成、线粒体生物发生和自噬来改善脂肪变性
Swati Katoch,Jatin,Vishal Acharya et al.
Swati Katoch et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is marked by excessive fat accumulation in the hepatocytes. In the present study, the protective efficacy of picroside I and II against steatosis was studied using combination...