Prostate cancer cells modulate the differentiation of THP-1 cells in response to etoposide and TLR agonists treatments [0.03%]
前列腺癌细胞调节THP-1细胞分化以响应依托泊苷和TLR激动剂治疗
Somaiyeh Malekghasemi,Jafar Majidi,Behzad Baradaran et al.
Somaiyeh Malekghasemi et al.
The aim of this study was to determine the polarization of macrophages in the tumor microenvironment, as well as the effect of soluble factors secreted from these polarized macrophages on etoposide-induced cancer cell apoptosis. We investig...
Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation [0.03%]
FGF-21过表达保护间充质干细胞免于氧化应激和炎症诱导的caspase依赖性细胞凋亡损伤
Gabriel R Linares,Yan Leng,Dragan Maric et al.
Gabriel R Linares et al.
The clinical application of stem cells offers great promise as a potential avenue for therapeutic use in neurodegenerative diseases. However, cell loss after transplantation remains a major challenge, which currently plagues the field. On t...
Delivery of BR2-SOX17 fusion protein can inhibit cell survival, proliferation, and invasion in gastric cancer cells through regulating Klotho gene expression [0.03%]
BR2-SOX17融合蛋白通过调节长寿蛋白基因表达抑制胃癌细胞生存、增殖和侵袭
Lixia Yang,Yue Wu,Heli He et al.
Lixia Yang et al.
The prognosis of advanced gastric cancer is poor and understanding the biology and subsequent development of new targeting therapy is still an urgent need. This study was conducted to explore the effect of BR2 (a 17-amino acid peptide)-SOX1...
ABCC9, NKAPL, and TMEM132C are potential diagnostic and prognostic markers in triple-negative breast cancer [0.03%]
ABCC9、NKAPL和TMEM132C是三阴性乳腺癌潜在的诊断及预后标志物
Xiaoyu Zhang,Xiaoning Kang,Lijun Jin et al.
Xiaoyu Zhang et al.
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. The aim of this study is to identify the diagnostic and poor prognostic signatures in TNBC by exploring the aberrant DNA methylation and gene expression. Differential e...
miR-582-5p serves as an antioncogenic biomarker in intermediate risk AML with normal cytogenetics and could inhibit proliferation and induce apoptosis of leukemia cells [0.03%]
miR-582-5p可作为正常核型中危AML的抗肿瘤生物标志物并能抑制白血病细胞增殖及诱导凋亡
Xiaman Wang,Yuandong Feng,Peihua Zhang et al.
Xiaman Wang et al.
Numerous studies confirmed that aberrant microRNA (miRNA) expression contributes to cancer development and progression. We carried out this study to explore the expression profile of miRNAs in intermediate risk acute myeloid leukemia (AML) ...
LncRNA-XIST promotes the oxidative stress-induced migration, invasion, and epithelial-to-mesenchymal transition of osteosarcoma cancer cells through miR-153-SNAI1 axis [0.03%]
长链非编码RNA-XIST通过miR-153-SNAI1轴促进氧化应激诱导的骨肉瘤细胞迁移、侵袭和上皮间充质转化
Ji-Feng Wen,Yong-Qing Jiang,Chao Li et al.
Ji-Feng Wen et al.
Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on un...
Mechanisms of programmed cell death in the midgut and salivary glands from Bradysia hygida (Diptera: Sciaridae) during pupal-adult metamorphosis [0.03%]
布拉迪希亚蛹期-成虫变态中期肠和唾液腺程序性细胞死亡的分子机制研究
Thaylise de Cassia Santos Przepiura,Aryelle M Navarro,Rafaela da Rosa Ribeiro et al.
Thaylise de Cassia Santos Przepiura et al.
Programmed cell death is involved with the degeneration/remodeling of larval tissues and organs during holometabolous development. The midgut is a model to study the types of programmed cell death associated with metamorphosis because its s...
Nazanin Fathi,Nima Rezaei
Nazanin Fathi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS-C...
May we target double-membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection? [0.03%]
能否以双层膜小泡和氧化固醇结合蛋白为靶标来对抗SARS-CoV-2感染？
Shiva Shahmohamadnejad,Seyed Fazel Nabavi,Solomon Habtemariam et al.
Shiva Shahmohamadnejad et al.
Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy [0.03%]
Circular RNA hsa_circ_0085131通过调节自噬参与非小细胞肺癌的顺铂耐药性
Rui Kong
Rui Kong
Non-small-cell lung carcinoma (NSCLC) continues to top the list of cancer mortalities worldwide. The role of circular RNAs (circRNAs) in tumorigenesis has been increasingly appreciated, although it is relatively unexplored in NSCLC. Herein,...