AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis [0.03%]
AMPK激活抑制mTOR/S6K1磷酸化并在脓毒症大鼠中诱导亮氨酸抵抗
Mengyao Shi,Zunqi Hu,Xin Zhang et al.
Mengyao Shi et al.
Although it has been known that protein synthesis is suppressed in sepsis, which cannot be corrected by leucine supplement (also known as leucine resistance), the molecular signaling mechanism remains unclear. This study aimed to investigat...
c-Myc-mediated SNRPB upregulation functions as an oncogene in hepatocellular carcinoma [0.03%]
c-Myc介导的SNRPB上调在肝细胞癌中发挥致癌作用
Ningfu Peng,Jindu Li,Jingrong He et al.
Ningfu Peng et al.
Dysregulation of genes involved in alternative splicing contributes to hepatocarcinogenesis. SNRPB, a component of spliceosome, is implicated in human cancers, yet its clinical significance and biological function in hepatocellular carcinom...
MiR-643 inhibits lipopolysaccharide-induced endometritis progression by targeting TRAF6 [0.03%]
miR-643通过靶向TRAF6抑制脂多糖诱导的子宫内膜炎进展
Rui Zhao,Jing Wang,Xiaojuan Zhang et al.
Rui Zhao et al.
Endometritis is a prevalent disease with inflammation of uterus endangering women reproductive health. MicroRNAs (miRNAs) play important roles in inflammatory disorders, including endometritis. However, the role and mechanism of miR-643 in ...
Epiregulin promotes osteogenic differentiation and inhibits neurogenic trans-differentiation of adipose-derived mesenchymal stem cells via MAPKs pathway [0.03%]
表皮生长因子 Epiregulin通过MAPKs 途径促进脂肪源间充质干细胞成骨分化并抑制其神经转分化的研究
Yangyang Cao,Ruitang Shi,Haoqing Yang et al.
Yangyang Cao et al.
Mesenchymal stem cells (MSCs) exists low efficiency to trans-differentiate into other germinal layer cell types. One key issue is to discover the effect of important factor on MSCs differentiation abiltiy. In this study, we investigated the...
Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell [0.03%]
酪氨酸硝化作为信号转导中的关键事件调控细胞功能状态
Mariya Sabadashka,Mariia Nagalievska,Nataliia Sybirna
Mariya Sabadashka
This review is dedicated to the role of nitration of proteins by tyrosine residues in physiological and pathological conditions. First of all, we analyze the biochemical evidence of peroxynitrite formation and reactions that lead to its for...
UNC5B-AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2 [0.03%]
UNC5B-AS1通过EZH2调节NDRG2的H3K27me促进卵巢癌进展
Hao Wang,Hong Su,Yujie Tan
Hao Wang
The role of long non-coding RNAs (lncRNAs) in tumorigenesis and development of ovarian cancer (OC) has caught the attention of scientists. UNC5B antisense RNA 1 (UNC5B-AS1) is a newly identified carcinogenic lncRNA in thyroid papillary carc...
Gimmicks of gamma-aminobutyric acid (GABA) in pancreatic β-cell regeneration through transdifferentiation of pancreatic α- to β-cells [0.03%]
关于通过胰岛α细胞重编程为β细胞的方式促进胰岛β细胞再生的γ氨基丁酸作用机制探讨
Zhao Yi,Muhammad Waseem Ghani,Hammad Ghani et al.
Zhao Yi et al.
In vivo regeneration of lost or dysfunctional islet β cells can fulfill the promise of improved therapy for diabetic patients. To achieve this, many mitogenic factors have been attempted, including gamma-aminobutyric acid (GABA). GABA rema...
Fructose-1,6-bisphosphatase degradation in the methylotrophic yeast Komagataella phaffii occurs in autophagy pathway [0.03%]
甲基营养型酵母Komagataellaphaffii中的果糖-1,6-二磷酸酶降解发生在自噬途径中
Olena Dmytruk,Nina Bulbotka,Anastasya Zazulya et al.
Olena Dmytruk et al.
Many enzymes of methanol metabolism of methylotrophic yeasts are located in peroxisomes whereas some of them have the cytosolic localization. After shift of methanol-grown cells of methylotrophic yeasts to glucose medium, a decrease in the ...
Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway [0.03%]
外泌体衍生的环状RNA circ_SLC19A1通过miR-497/Septin 2通路促进前列腺癌细胞增殖和侵袭
Yu Zheng,Jian-Xin Li,Chao-Jiang Chen et al.
Yu Zheng et al.
The occurrence and development of prostate cancer (PCa) is complex, and the related mechanism is not fully understood. Current studies have found that extracellular vesicles (EVs) and circular RNAs (circRNAs) have important functions in var...
LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma [0.03%]
LDOC1在甲状腺癌中的差异表达及其在乳头状甲状腺癌中的抑瘤功能研究
Shuiying Zhao,Yanyan Zhao,Qingzhu Wang et al.
Shuiying Zhao et al.
The leucine zipper downregulated in cancer 1 (LDOC1) has been proposed as a regulator of transcription and cell signaling. We have previously demonstrated that LDOC1 is differentially expressed in papillary thyroid carcinoma (PTC), this stu...