Optimization of chemical induction conditions for human herpesvirus 8 (HHV-8) reactivation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) from latently-infected BC-3 cells [0.03%]
12-十四酰佛波酯13-乙酸酯(TEPA)化学诱导人类疱疹病毒8型(HHV-8)潜伏感染的BC-3细胞复苏的最佳化研究
Wenbin Ma,Teresa A Galvin,Hailun Ma et al.
Wenbin Ma et al.
Human herpesvirus 8 (HHV-8) persists as episomal DNA in latently-infected cells and can establish two alternative life cycles, latent or lytic. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is a known inducer of HHV-8 in several human primary...
Improving heat stability of haemagglutinating antigens for avian influenza [0.03%]
提高禽流感病毒血凝素抗原热稳定的措施
Matteo Samuele Pizzuto,Paola De Benedictis,Silvia Maniero et al.
Matteo Samuele Pizzuto et al.
The increasing demand for avian influenza diagnostic reagents worldwide, has included requests for significant supplies of product to developing countries. Difficulties in dispatching to remote areas and tropical countries are a major conce...
José María Gutiérrez,Guillermo León,Thierry Burnouf
José María Gutiérrez
The parenteral administration of antivenoms is the cornerstone of snakebite envenoming therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are available world-wide. We address the main issues to be considered...
Development of inactivated trivalent vaccine for the teratogenic Aino, Akabane and Chuzan viruses [0.03%]
用于致畸性爱ino、Akabune和Chuzan病毒的灭活三价疫苗的研发
Yeon-Hee Kim,Chang-Hee Kweon,Dong-Seob Tark et al.
Yeon-Hee Kim et al.
Aino, Akabane and Chuzan viruses are arthropod-borne (arbo) viruses transmitted by blood-sucking insects like mosquitoes and Culicoides biting midges. These arbovirus infections are mainly associated with abortion, stillbirth and congenital...
Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70 [0.03%]
基于ESAT-6及截短的HSP70蛋白C末端片段融合抗原的研究克隆、表达及免疫学性质分析
Majid Tebianian,Ahmad Zavaran Hoseini,Seyyed Mahmoud Ebrahimi et al.
Majid Tebianian et al.
Tuberculosis (TB) remains as a major public health problem worldwide. Identification and selection of immunodominant antigens of Mycobacterium tuberculosis (MTB), capable of efficiently inducing a protective immune response is the ultimate ...
Three Rs Approaches in the Production and Quality Control of Fish Vaccines [0.03%]
鱼类疫苗生产和质量控制中的3R策略
Paul J Midtlyng,Coenraad Hendriksen,Elisabeth Balks et al.
Paul J Midtlyng et al.
The workshop on Three Rs Approaches in the Production and Quality Control of Fish Vaccines aimed a) to identify animal tests currently stipulated for the production and quality control of fish vaccines and to highlight animal welfare concer...
Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients [0.03%]
自体浓缩血小板治疗老年患者难治性压疮
N Greppi,L Mazzucco,G Galetti et al.
N Greppi et al.
We evaluated growth factor contents and clinical efficacy of allogeneic platelet gel (PG) prepared with standard blood banking procedures from routine platelet concentrates (PCs) obtained from buffy coats. The PGs were used to treat 11 hypo...
Taking immunogenicity assessment of therapeutic proteins to the next level [0.03%]
治疗性蛋白质免疫原性评估向更高水平迈进
I C Büttel,P Chamberlain,Y Chowers et al.
I C Büttel et al.
Therapeutic proteins provide innovative and effective therapies for numerous diseases. However, some of these products are associated with unwanted immunogenicity that may lead to clinical consequences such as reduced or loss of efficacy, a...
Improving the characteristics of a mycobacterial 16 kDa-specific chicken scFv [0.03%]
改良鸡源分支杆菌特异性16KD单链抗体(scFv)的特性
Joy Sixholo,Wouter Van Wyngaardt,Cordelia Mashau et al.
Joy Sixholo et al.
Recombinant antibodies can be engineered to improve their binding or other characteristics. A chicken single chain variable fragment (scFv) phage display library was panned against the mycobacterial 16 kDa antigen. Three fusion phages which...
Development of a real-time reverse-transcription-PCR method for detection of RD114 virus in canine vaccines [0.03%]
犬疫苗中RD114病毒实时RT-PCR检测方法的建立
Rie Narushima,Tomoaki Shimazaki,Toshio Takahashi
Rie Narushima
It is known that certain feline cell lines, such as the Crandell-Rees feline kidney cell, produce an RD-114-like virus. As a feline endogenous retrovirus, RD114 virus, exists in the genome of all cats, it can be assumed that contamination w...