Adjuvant Synergy: Alum and chlorogenic acid enhance Th1 responses and survival in a Salmonella typhimurium challenge model [0.03%]
佐剂协同效应：矾和氯原酸在沙门氏菌感染模型中增强Th1反应并提高存活率
Mahtab Pourkamalzadeh,Seyyed Meysam Abtahi Froushani,Abdolgaffar Ownagh
Mahtab Pourkamalzadeh
Alum adjuvants do not induce Th1 responses with killed microorganisms, although Th1 responses are crucial for defending against intracellular microbes. Chlorogenic acid (CGA) can shift immune responses from Th2 toward Th1. This study assess...
Octanoic acid addition: a simple, affordable modification that overcomes lipid removal limitations of traditional antivenom production processes [0.03%]
辛酸添加：一项简单的低成本改进措施，可克服传统抗蛇毒血清生产过程中的脂质去除限制
Nicolás Berardo Blanch,Diego Ignacio Olivero,Christian Leandro Macoretta et al.
Nicolás Berardo Blanch et al.
Since their introduction over a century ago, antivenoms have played a central role in Public Health, especially in the world's least developed regions. They are, in most cases, the only effective treatment for envenomation accidents by pois...
Conference report WHO informal consultation on the draft WHO Guideline on the phasing out of animal tests for the quality control of biological products [0.03%]
世卫组织关于生物制品质量控制中淘汰动物实验的指导原则草案非正式咨询会议报告
Ian Feavers,Dianliang Lei,Catherine Milne et al.
Ian Feavers et al.
Animal testing has long supported the development and quality control of biotherapeutics and vaccines by ensuring safety and efficacy. However, its variability and time-consuming nature can delay product availability. Advances in non-animal...
A new Japanese regulatory perspective regarding the indication extrapolation between approved intravenous immunoglobulins (IVIg) products based on comparability assessments of quality attributes [0.03%]
日本药品监管机构关于静脉注射免疫球蛋白产品适应症外推的最新观点——基于质量属性可比性评估
Takashi Kameda,Kazuki Nagashima,Shun Masuta et al.
Takashi Kameda et al.
Intravenous immunoglobulin (IVIg) product is a pooled human plasma-derived IgG medicinal product indicated for various immunodeficiency and autoimmune diseases. These indications have essentially been approved in Japan based on clinical eva...
Report of the fourth conference on next-generation sequencing (NGS) for adventitious virus detection in biologics for humans and animals: Validation and implementation of NGS [0.03%]
第四届生物制品外源病毒检测下一代测序技术（NGS）会议报告：NGS的验证与实施
Arifa S Khan,Laurent Mallet,Johannes Blümel et al.
Arifa S Khan et al.
This report is a summary of the 4th Conference on NGS for Adventitious Virus Detection, which took place on December 4-5, 2024, in Frankfurt, Germany, and was sponsored by the International Alliance for Biological Standardization (IABS), an...
Corrigendum to "Effect of biomolecules derived from human platelet-rich plasma on the ex vivo expansion of human adipose-derived mesenchymal stem cells for clinical applications" [Biologicals 75 (2022) 37-48] [0.03%]
“人血小板丰富胎盘衍生生物分子对人类脂肪组织间充质干细胞体外扩增的影响》的勘误(期刊：生物制品卷期：75, 2022,页码：37-48)” corrections
Silvia M Becerra-Bayona,Víctor Alfonso Solarte,Juan Dario Alviar Rueda et al.
Silvia M Becerra-Bayona et al.
Corrigendum to "Vaccination and surveillance for high pathogenicity avian influenza in poultry-current situation and perspectives" [Biologicals 91 (2025) 101840] [0.03%]
关于“家禽高致病性禽流感的疫苗接种和监测——当前形势与展望”一文的勘误(生物制品第91卷(2025)篇101840)
Nancy C Sajjadi,Celia Abolnik,Francesca Baldinelli et al.
Nancy C Sajjadi et al.
Evaluation of 1st WHO anti-malaria reference reagent for competition ELISA harmonisation and development of ADAMSEL analytical platform [0.03%]
评估WHO首个人类疟疾抗体参比品及其在ADAMSEL分析平台开发中的应用价值
Bhagwati Khatri,Peggy Riese,Hanna Shkarlet et al.
Bhagwati Khatri et al.
This study focuses on harmonising the competition ELISA (cELISA) assay for Plasmodium falciparum (P. falciparum), using the 1st WHO reference reagent for anti-malaria (P. falciparum) human reference serum (10/198). Antibody-mediated immune ...
The pharmacokinetics and safety comparison of Zamerovimab and Mazorelvimab monoclonal antibodies vs. HRIG in category III rabies post-exposure prophylaxis: a stratified analysis by wound characteristics [0.03%]
扎莫维单抗和马佐雷维单抗与HRIG三类狂犬病暴露后被动免疫制剂的药动学及安全性比较：不同伤口类型的分层分析
Xiaoqiang Liu,Yongxian Zha,Zhengxiong Wang et al.
Xiaoqiang Liu et al.
Objective: To compare rabies virus neutralizing antibody (RVNA) kinetics and safety profiles of Zamerovimab and Mazorelvimab monoclonal antibodies (mAbs) versus human rabies immunoglobulin (HRIG) in Category III rabies-ex...
Functional characterization of the Clostridium perfringens quadruple point mutant epsilon toxin [0.03%]
芽孢杆菌ε毒素四重突变体的功能表征
Roopa Anandamurthy Hemanth,Mandrira Ramakrishna Namrutha,Suresh Bindu et al.
Roopa Anandamurthy Hemanth et al.
Epsilon toxin (Etx) is one of the exotoxins (∼18) secreted by the spore-forming bacterium Clostridium perfringens, which plays a major role in the pathogenesis of enterotoxaemia (ET) leading to sudden death in affected small ruminants. A c...