Future of TABST and LABST in the Indian Pharmacopoeia Monographs A Humane Society International/India Workshop Report [0.03%]
关于人道社会协会在印度药典单行本中关于TABST和LABST未来的工作室报告
Brinda Poojary,Laura Viviani,Alokparna Sengupta et al.
Brinda Poojary et al.
Humane Society International India (HSI India) organized and facilitated a workshop on the 'Future of Target Animal Batch Safety Test (TABST) and Laboratory Animal Batch Safety Test (LABST) in the Indian Pharmacopoeia (IP) Monographs'. The ...
Experimental cystic echinococcosis as a proof of concept for the development of peptide-based vaccines following a novel rational workflow [0.03%]
基于肽的疫苗开发的概念验证——以囊尾蚴病为例的新理性工作流程研究实验
Sebastian Miles,Sylvia Dematteis,Gustavo Mourglia-Ettlin
Sebastian Miles
Vaccines are among the most important advances in medicine throughout the human history. However, conventional vaccines exhibit several drawbacks in terms of design and production costs. Peptide-based vaccines are attractive alternatives, s...
Rapid production and free distribution of a synthetic RNA material to support SARS-CoV-2 molecular diagnostic testing [0.03%]
快速生产并免费提供一种合成RNA材料以支持SARS-CoV-2分子诊断测试
Megan H Cleveland,Erica L Romsos,Carolyn R Steffen et al.
Megan H Cleveland et al.
In response to the COVID-19 pandemic, the National Institute of Standards and Technology released a synthetic RNA material for SARS-CoV-2 in June 2020. The goal was to rapidly produce a material to support molecular diagnostic testing appli...
Development of a droplet digital PCR for pertussis toxin locus copy number determination in a genetically-modified Bordetella pertussis strain [0.03%]
开发用于测定百日咳博德特氏菌基因改造菌株毒素基因拷贝数的微滴式数字PCR方法
Raphaël Esson,Stéphanie Falque,Eric Abachin et al.
Raphaël Esson et al.
To improve pertussis toxin (PT) yield in B. pertussis strains for vaccine production a genetically-engineered strain (gdPT 191-134 strain) with a second copy of the genetically detoxified PT (gdPT) locus was developed. The consistency of th...
Collaborative study for the calibration of a replacement International Standard for Diphtheria Antitoxin Equine [0.03%]
白喉抗毒素国际标准马血清替代品协作定值研究
Laura Hassall,Peter Rigsby,Paul Stickings
Laura Hassall
The International Standard for Diphtheria Antitoxin Equine is essential for the standardisation of assays used to determine the potency of therapeutic diphtheria antitoxin products produced from equine serum. This paper describes the produc...
A collaborative study to establish the second national standard for hepatitis B immunoglobulin in Korea [0.03%]
韩国第二国家标准乙型肝炎免疫球蛋白协作研究
Chan Woong Choi,Su Kyoung Seong,Ki Won Han et al.
Chan Woong Choi et al.
This study aimed to establish a second national standard for hepatitis B immunoglobulin (HBIG) that can be used for potency assays of hepatitis B and normal immunoglobulin. The candidate material was manufactured using a process approved as...
An ELISA system for tetanus toxoid potency tests: An alternative to lethal challenge [0.03%]
破伤风类毒素效力检测的ELISA系统及替代致死性检验的方法
Masaaki Iwaki,Tsuyoshi Kenri,Mitsutoshi Senoh
Masaaki Iwaki
For a long time, a widely used method for tetanus toxoid (Ttd) potency has been the challenge test, in which animals are immunized and then challenged with tetanus toxin in lethal or non-lethal way. In the context of animal welfare, an alte...
Parivash Ranjbarian,Zahra Sobhi Amjad,Roya Chegene Lorestani et al.
Parivash Ranjbarian et al.
The treatment of Klebsiella pneumoniae is faced with challenges demanding the development of a vaccination strategy. However, no approved and globally available vaccine exists yet. This study aimed to systematically review all published dat...
Dose-sparing effect of Sabin-derived inactivated polio vaccine produced in Japan by intradermal injection device for rats [0.03%]
日本生产的萨宾株脊灰灭活疫苗用于SD大鼠皮内免疫的节苗效果观察
Eriko Itoh,Sakiko Shimizu,Yasushi Ami et al.
Eriko Itoh et al.
The live-attenuated oral polio vaccine has long been used as the standard for polio prevention, but in order to minimize the emergence of pathogenic revertants, the inactivated polio vaccine (IPV), which is administered intramuscularly or s...
A highly sensitive and robust LC-MS platform for host cell protein characterization in biotherapeutics [0.03%]
一种用于生物疗法中宿主细胞蛋白表征的高度灵敏且稳健的LC-MS平台
Qinqin Ji,Izabela Sokolowska,Rui Cao et al.
Qinqin Ji et al.
Host cell proteins (HCPs) are a major class of process-related impurities that need to be closely monitored during the production of biotherapeutics. Mass spectrometry (MS) has emerged as a promising tool for HCP analysis due to its specifi...