The future of pyrogenicity testing: Phasing out the rabbit pyrogen test. A meeting report [0.03%]
有关停止使用家兔致热原试验的会议报道——致热原试验的发展方向
Gwenaël Cirefice,Katrin Schütte,Ingo Spreitzer et al.
Gwenaël Cirefice et al.
The rabbit pyrogen test (RPT) was the benchmark for pyrogenicity testing, but scientific advancements have provided innovative and humane methods, such as the in vitro monocyte-activation test (MAT). However, transitioning from the RPT to t...
CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cells [0.03%]
CDC20是抑制MDCK细胞肿瘤发生的潜在靶基因
Zhenbin Liu,Mengyuan Pei,Geng Liu et al.
Zhenbin Liu et al.
MDCK is currently the main cell line used for influenza vaccine production in culture. Previous studies have reported that MDCK cells possess tumorigenic ability in nude mice. Although complete cell lysis can be ensured during vaccine produ...
Tumorigenesis mechanism and application strategy of the MDCK cell line: A systematic review [0.03%]
MDCK细胞系肿瘤发生的机制及应用策略：系统评价研究
Di Yang,Lingwei Huang,Jiamin Wang et al.
Di Yang et al.
Influenza is an acute respiratory infectious disease caused by influenza virus that seriously endangers people's health. Influenza vaccination is the most effective means to prevent influenza virus infection and its serious complications. M...
Stability of lyophilized Meningococcal A conjugate vaccine, (MenAfriVac™) at elevated temperatures to support controlled temperature chain (CTC) claim [0.03%]
冻干脑膜炎球菌A结合疫苗（MenAfriVacTM）在高温下的稳定性研究以支持其温控链（CTC）的温度上限要求
Sunil Gairola,Prashant Bonde,Pankaj Sharma et al.
Sunil Gairola et al.
Meningococcal A Conjugate Vaccine (MenAfriVac) is the world's first Monovalent Conjugate Vaccine against Neisseria Meningitidis serogroup A which has obtained Controlled Temperature Chain (CTC) label claim of "stable upto 40°C for 4 days p...
On-column virus inactivation by solvent/detergent treatment for a recombinant biological product [0.03%]
用于重组生物制品的柱上病毒灭活工艺：溶剂/ detergent处理法
Daniel Polasek,Andreas Flicker,Christian Fiedler et al.
Daniel Polasek et al.
Each process step in the manufacture of biological products requires expensive resources and reduces total process productivity. Since downstream processing of biologicals is the main cost driver, process intensification is a persistent top...
3Rs implementation in veterinary vaccine batch-release testing: Current state-of-the-art and future opportunities. A webinar and workshop report [0.03%]
兽医疫苗批签发检测中的3R实施：现状与未来机遇——网络研讨会及研讨会报告
Laura Viviani,Elisabeth Balks,Sonja Beken et al.
Laura Viviani et al.
Regulatory authorities require veterinary batch-release testing to confirm vaccine potency and safety, but these tests have traditionally relied on large numbers of laboratory animals. Advances in vaccine research and development offer incr...
Epidemiology-driven approaches to surveillance in HPAI-vaccinated poultry flocks aiming to demonstrate freedom from circulating HPAIV [0.03%]
基于流行病学的家禽HPAI免疫群监测方法以证明无高致病性禽流感病毒传播存在的存在
Timm Harder,Sjaak de Wit,Jose L Gonzales et al.
Timm Harder et al.
Incursion pressure of high pathogenicity avian influenza viruses (HPAIV) by secondary spread among poultry holdings and/or from infected migratory wild bird populations increases worldwide. Vaccination as an additional layer of protection o...
Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals [0.03%]
第三届生物制品外源病毒检测下一代测序技术会议报告
Arifa S Khan,Laurent Mallet,Johannes Blümel et al.
Arifa S Khan et al.
Next-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Foo...
Enhanced productivity and stability of PRV in recombinant ST-Tret1 cells [0.03%]
重组ST-Tret1细胞中PRV的生产力和稳定性的提高
Yue Xu,Xi Bao,Li Chen et al.
Yue Xu et al.
Productivity and stability of Pseudorabies virus (PRV) are critical for the manufacture and storage of live attenuated pseudorabies vaccine. Trehalose is commonly used as a cryoprotectant to stabilize organisms during freezing and lyophiliz...
Confirming the absence of parental African swine fever virus as a potential contaminant of recombinant live attenuated ASF vaccines [0.03%]
确认非洲猪瘟病毒不在重组弱毒疫苗中潜在污染存在的可能性
Lauro Velazquez-Salinas,Elizabeth Ramirez-Medina,Ayushi Rai et al.
Lauro Velazquez-Salinas et al.
African swine fever (ASF) is a devastating disease that is currently producing a panzootic significantly impacting the swine industry worldwide. One of the major challenges for advancing the development of ASF vaccines has been the absence ...