Ethical approval for controlled human infectious model clinical trial protocols - A workshop report [0.03%]
控制人类感染模型临床试验方案的伦理批准-一个研讨会报告
Euzebiusz Jamrozik,Katherine Littler,Irina Meln et al.
Euzebiusz Jamrozik et al.
Controlled Human Infectious Model studies (CHIM) involve deliberately exposing volunteers to pathogens. To discuss ethical issues related to CHIM, the European Vaccine Initiative and the International Alliance for Biological Standardization...
Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023 [0.03%]
第四届控制人类感染模型（CHIM）会议，关于CHIM的监管问题，2023年5月24日
Marco Cavaleri,David Kaslow,Eric Boateng et al.
Marco Cavaleri et al.
Many aspects of Controlled Human Infection Models (CHIMs, also known as human challenge studies and human infection studies) have been discussed extensively, including Good Manufacturing Practice (GMP) production of the challenge agent, CHI...
A validated polyclonal antiserum-based immunoassay for assessment of HPV 16 L1 relative potency [0.03%]
用于评估HPV 16 L1相对效力的多克抗体免疫测定法的验证
Reihaneh Mirhassani,Ehsan Seyedjafari,Behrouz Vaziri
Reihaneh Mirhassani
Vaccine potency is typically evaluated using an assay that acts as a surrogate for biological activity. Although in vivo vaccines better represent human immunological responses, in vitro assays are preferred due to lower variability, higher...
Molecular characterization of Anaplasma ovis Msp4 protein in strains isolated from ticks in Turkey: A multi-epitope synthetic vaccine antigen design against Anaplasma ovis using immunoinformatic tools [0.03%]
土耳其蜱虫中分离的Anaplasma ovis Msp4蛋白分子特征：使用免疫信息学工具设计用于抵抗Anaplasma ovis的多表位合成疫苗抗原
Ahmet Efe Köseoğlu,Hüseyin Can,Mervenur Güvendi et al.
Ahmet Efe Köseoğlu et al.
Tick-borne pathogens increasingly threaten animal and human health as well as cause great economic loss in the livestock industry. Among these pathogens, Anaplasma ovis causing a decrease in meat and milk yield is frequently detected in she...
Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report [0.03%]
挑战菌株研发及GMP生产的规范研讨会报告
Nicoletta Corti,Christopher Chiu,Rebecca J Cox et al.
Nicoletta Corti et al.
Within the Innovative Health Initiative (IHI) Inno4Vac CHIMICHURRI project, a regulatory workshop was organised on the development and manufacture of challenge agent strains for Controlled Human Infection Model (CHIM) studies. Developers ar...
Novel vaccine candidates of Bordetella pertussis identified by reverse vaccinology [0.03%]
反向疫苗学鉴别百日咳博德特氏菌新型疫苗候选物
Gloria Paulina Monterrubio-López,José Luis Llamas-Monroy,Ángel Antonio Martínez-Gómez et al.
Gloria Paulina Monterrubio-López et al.
Whooping cough is a disease caused by Bordetella pertussis, whose morbidity has increased, motivating the improvement of current vaccines. Reverse vaccinology is a strategy that helps identify proteins with good characteristics fast and wit...
Efficient extraction of adventitious virus nucleic acid using commercially available methods [0.03%]
使用商用方法有效提取偶然病毒核酸
William G Valiant,Jon Borman,Kang Cai et al.
William G Valiant et al.
An essential step in pharmaceutical product development is screening for contamination with adventitious agents, and there is desire to develop highly sensitive assays to detect adventitious viral nucleic acid. This study sought to examine ...
Evaluation of next-generation sequencing performance for in vitro detection of viruses in biological products [0.03%]
体外检测生物制品中病毒的下一代测序性能评估
Takamasa Hirai,Kiyoko Kataoka,Yuzhe Yuan et al.
Takamasa Hirai et al.
Next-Generation Sequencing (NGS) can detect nucleic acid sequences in a massively parallel sequencing. This technology is expected to be widely applied for the detection of viral contamination in biologics. The recently published ICH-Q5A (R...
Adjuvant effects of novel water/oil emulsion formulations on immune responses against infectious bronchitis (IB) vaccine in mice [0.03%]
新型水包油乳剂佐剂对小鼠传染性支气管炎疫苗免疫反应的影响研究
Karrar Ali Mohammed Hasan Alsakini,Furkan Ozan Çöven,Ayse Nalbantsoy
Karrar Ali Mohammed Hasan Alsakini
Vaccines have long made use of adjuvants to boost the immune response of the body and reduce the amount of vaccine needed as well as the expense of producing the vaccine. Many vaccine adjuvants are in development, but their application in v...
Nanoparticle formulation for the development of a dog nanovaccine against Cystic Echinococcosis [0.03%]
用于开发治疗囊尾蚴病的纳米疫苗的纳米颗粒配方
Cecilia Silvarrey,Gabriela Alvite,Adriana Esteves
Cecilia Silvarrey
Cystic Echinococcosis is a cosmopolitan zoonosis closely linked to poverty and ignorance. It affects both cattle and humans, causing significant losses to both human and animal health. To date, there is no effective way to combat this. Our ...