Central liver-expressed antimicrobial peptide 2 induces anxiety- and depression-related behaviors and activates the hypothalamic-pituitary-adrenal axis in male mice [0.03%]
中央肝表达的抗菌肽2诱导小鼠焦虑和抑郁症行为并激活下丘脑-垂体-肾上腺轴
Maximilian Tufvesson-Alm,Elisabet Jerlhag
Maximilian Tufvesson-Alm
The ghrelinergic system is a key regulator of feeding and metabolism. Beyond this, the ghrelinergic system has been implicated for reward, anxiety and depression. In this regard, the effects of the endogenous ghrelin receptor inverse agonis...
Neonatal lipopolysaccharide has long-term effects on steroids and gene expression in the adult mouse brain [0.03%]
脂多糖对成年小鼠脑类固醇和基因表达的长期影响
Hitasha Bajaj,Melody Salehzadeh,Anna Mazurenko et al.
Hitasha Bajaj et al.
Early-life infections can exert profound and lasting effects on brain development and function, potentially through sustained alterations in glucocorticoid (GC) signaling. Here, we investigated whether a neonatal immune challenge alters bra...
The competitive side of social living: Maternal hormonal programming and phenotypic outcomes in blue tit offspring [0.03%]
社交生活中的竞争性：蓝雀后代母体激素编程和表型结果
Alejandro García-Antón,Wendt Müller,Jorge García-Campa et al.
Alejandro García-Antón et al.
Social interactions are vital in animal life, providing access to key information about foraging opportunities, mates, and predators. Yet in highly competitive environments, being social can be costly, as increased interaction rates may lea...
Paternal deprivation in biparental zebra finches (Taeniopygia guttata) affects care of offspring with consequences for adult stress-induced corticosterone levels [0.03%]
父本剥夺对双亲照顾斑胸草雀后代的影响及其对成年斑胸草雀压力诱导的皮质酮水平的影响
Angela K Goff-Riley,Jennifer L Grindstaff
Angela K Goff-Riley
The development of the hypothalamic-pituitary-adrenal (HPA) axis is sensitive to early life perturbations. We examined how an early-life perturbation, paternal deprivation, affects the HPA axis development of offspring and how maternal beha...
Androgen receptor modulation of vocal circuitry in Alston's singing mouse [0.03%]
雄激素受体在阿尔斯顿唱歌鼠发声环路中的调节作用
Da-Jiang Zheng,Britt Mardis,Denise Lam et al.
Da-Jiang Zheng et al.
Animal advertisement displays are dramatic, often sexually dimorphic behaviors that function in both courtship and competition, and require the coordinated modulation of diverse motivational and motor circuits. In Alston's singing mice, Sco...
Estrogen regulates cognitive function in APP/PS1 female mice via modulation of IDO1-mediated Trp/Kyn metabolism through ERβ [0.03%]
雌激素通过雌二醇受体β调节APP/PS1雌鼠IDO1介导的色氨酸及其代谢物对认知功能的影响
Lingdi Zhang,Shuang Hu,Jianjun Zhu et al.
Lingdi Zhang et al.
Alzheimer's disease (AD) is more prevalent in postmenopausal women, possibly due to estrogen deficiency. IDO1 (Indoleamine 2,3-dioxygenase 1), a tryptophan-metabolizing enzyme, mediates immunomodulation and neuroinflammation and may be rela...
The gastric branch of the vagus nerve is required for hypothalamic pituitary axis stress habituation in male Sprague Dawley rats [0.03%]
迷走神经的胃支分支是雄性Sprague-Dawley大鼠下丘脑-垂体压力适应所必需的
Lori J Sampsell,Jonathan W Snyder,Alexandra Evans et al.
Lori J Sampsell et al.
The vagus nerve is known to participate in the negative feedback regulation of the hypothalamic pituitary adrenal (HPA) axis in response to acute stress, but the role of the vagus nerve in facilitating HPA habituation to repeated stress rem...
Sex-related differences in aggressive and emotional behavior in mice with the conditional inactivation of limbic Npy1r [0.03%]
条件性失活纹状体NPY受体的小鼠攻击行为和情绪行为的性别差异研究
Silvia Paterlini,Laura Gioiosa,Riccardo Panelli et al.
Silvia Paterlini et al.
Anxiety- and depression-related disorders are frequently associated with deficits in social behavior, including excessive aggression and violence, which may arise from disruptions in the neural circuits regulating emotions and social intera...
Early androgens and development of social personality traits: Evidence from classical congenital adrenal hyperplasia [0.03%]
早期雄激素与社交个性特征的发展：来自经典性腺发育不良的证据
Marcia L Collaer,Debra Spencer,Karson T F Kung et al.
Marcia L Collaer et al.
Experimental studies in nonhuman species have demonstrated the powerful effects of androgen exposure during early life on neurobehavioral development. Work also has demonstrated links between early androgens in humans and characteristics th...
Growing up in comfort: Environmental enrichment shapes maternal approach and sex differences in offspring neuroendocrine profiles in laboratory mice [0.03%]
舒适成长：环境富足形塑实验小鼠母性行为及后代神经内分泌性别差异
Lucas F Fowler,Alexandre Maekawa,T Nadine Burry et al.
Lucas F Fowler et al.
The physical environment modulates the maternal brain and affects maternal-offspring dynamics, with downstream effects on neonatal development. In this study, we examined whether environmental enrichment (EE) influences maternal approach, n...