Inbal Goshen,Raz Yirmiya
Inbal Goshen
Ample evidence demonstrates that the pro-inflammatory cytokine interleukin-1 (IL-1), produced following exposure to immunological and psychological challenges, plays an important role in the neuroendocrine and behavioral stress responses. S...
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor [0.03%]
G蛋白偶联受体(GPCR)的信号转导：促性腺激素释放激素受体的研究
Zvi Naor
Zvi Naor
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization, and treatment of sex hormone-dependent cancers, due to their ability to bring about 'chemical castr...
Give food a chance: treating anorexia nervosa without drugs and psychology [0.03%]
机会青睐美食：“厌食症”的治疗无需依靠药物和心理疗法
Jill E Schneider
Jill E Schneider
The eating disorder, anorexia nervosa, is a potentially lethal, leading cause of disability in young women, and a biological perspective on this important problem might further our understanding of the physiological control of energy balanc...
P Södersten,R Nergårdh,C Bergh et al.
P Södersten et al.
Outcome in anorexia nervosa remains poor and a new way of looking at this condition is therefore needed. To this aim, we review the effects of food restriction and starvation in humans. It is suggested that body weight remains stable and re...
Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases [0.03%]
雌激素的抗炎活性在大脑中的作用：针对更年期和神经退行性疾病的治疗机会
Elisabetta Vegeto,Valeria Benedusi,Adriana Maggi
Elisabetta Vegeto
Recent studies highlight the prominent role played by estrogens in protecting the central nervous system (CNS) against the noxious consequences of a chronic inflammatory reaction. The neurodegenerative process of several CNS diseases, inclu...
Frances A Champagne
Frances A Champagne
The transmission of traits across generations has typically been attributed to the inheritance by offspring of genomic information from parental generations. However, recent evidence suggests that epigenetic mechanisms are capable of mediat...
Dynamic regulation of estrogen receptor-alpha gene expression in the brain: a role for promoter methylation? [0.03%]
雌激素受体-α基因在脑中的表达是否通过启动子甲基化进行动态调节？
Melinda E Wilson,Jenne M Westberry,Amanda K Prewitt
Melinda E Wilson
Estrogen has long been known to play an important role in coordinating the neuroendocrine events that control sexual development, sexual behavior and reproduction. Estrogen actions in other, non-reproductive areas of the brain have also bee...
Eric B Keverne,James P Curley
Eric B Keverne
Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are herita...
Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems [0.03%]
早期生活环境和内分泌干扰物对生殖神经内分泌系统编程作用的影响
Andrea C Gore
Andrea C Gore
The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief pres...
Roberta Diaz Brinton,Richard F Thompson,Michael R Foy et al.
Roberta Diaz Brinton et al.
Emerging data indicate that progesterone has multiple non-reproductive functions in the central nervous system to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from t...