Mélanie Bourque,Dean E Dluzen,Thérèse Di Paolo
Mélanie Bourque
The sex difference in Parkinson's disease, with a higher susceptibility in men, suggests a modulatory effect of sex steroids in the brain. Numerous studies highlight that sex steroids have neuroprotective properties against various brain in...
Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens [0.03%]
蛋白磷酸酶和线粒体在雌激素神经保护作用中的功能
James W Simpkins,Kun Don Yi,Shao-Hua Yang
James W Simpkins
In the present treatise, we provide evidence that the neuroprotective and mito-protective effects of estrogens are inexorably linked and involve the ability of estrogens to maintain mitochondrial function during neurotoxic stress. This is a...
Shotaro Suzuki,Candice M Brown,Phyllis M Wise
Shotaro Suzuki
Our laboratory has investigated whether and how 17beta-estradiol (E(2)) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E(2), which are striki...
Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior [0.03%]
谁主沉浮？核受体辅激活子和辅抑制子在脑与行为中的作用
Marc J Tetel,Anthony P Auger,Thierry D Charlier
Marc J Tetel
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which ...
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease [0.03%]
黄体酮与维生素D激素联合治疗可能比单一疗法更有效地应对神经系统损伤和疾病
Milos Cekic,Iqbal Sayeed,Donald G Stein
Milos Cekic
More than two decades of pre-clinical research and two recent clinical trials have shown that progesterone (PROG) and its metabolites exert beneficial effects after traumatic brain injury (TBI) through a number of metabolic and physiologica...
Protective actions of ovarian hormones in the serotonin system of macaques [0.03%]
卵巢激素在猕猴血清素系统中的保护作用
Cynthia L Bethea,Arubala P Reddy,Yukari Tokuyama et al.
Cynthia L Bethea et al.
The serotonin neurons of the dorsal and medial raphe nuclei project to all areas of the forebrain and play a key role in mood disorders. Hence, any loss or degeneration of serotonin neurons could have profound ramifications. In a monkey mod...
Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis [0.03%]
性激素对神经炎症过程和实验性自身免疫性脑脊髓炎的影响
Markus Kipp,Cordian Beyer
Markus Kipp
Synthetic and natural estrogens as well as progestins modulate neuronal development and activity. Neurons and glia are endowed with high-affinity steroid receptors. Besides regulating brain physiology, both steroids conciliate neuroprotecti...
Keith N Fargo,Eileen M Foecking,Kathryn J Jones et al.
Keith N Fargo et al.
Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens ...
Luis M Garcia-Segura,Jacques Balthazart
Luis M Garcia-Segura
Gonadal hormones exert neuroprotective actions. In addition, it has become evident that the local synthesis of these molecules in the central nervous system may prevent or reduce neurodegeneration.The neuroprotective actions of steroids inv...
Evidence that RF-amide related peptides are inhibitors of reproduction in mammals [0.03%]
射频胺相关肽抑制哺乳动物繁殖的证据
Iain J Clarke,Y Qi,I Puspita Sari et al.
Iain J Clarke et al.
Gonadotropin releasing hormone (GnRH) secretion represents the final common pathway in the control of the reproductive axis. Dogma has been that GnRH is solely responsible for the control of gonadotropin secretion, but emerging data present...