Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications [0.03%]
大鼠新生期损伤的长期影响：性别差异、机制和临床意义
Jamie L LaPrairie,Anne Z Murphy
Jamie L LaPrairie
Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive ac...
Activation of progestin receptors in female reproductive behavior: Interactions with neurotransmitters [0.03%]
促黄体素受体在雌性生殖行为中的激活作用：与神经递质的相互作用
Shaila Mani,Wendy Portillo
Shaila Mani
The steroid hormone, progesterone (P), modulates neuroendocrine functions in the central nervous system resulting in alterations in physiology and reproductive behavior in female mammals. A wide body of evidence indicates that these neural ...
Aromatase in the brain of teleost fish: expression, regulation and putative functions [0.03%]
鱼类脑部 aromatase 的表达、调控和潜在功能
Nicolas Diotel,Yann Le Page,Karen Mouriec et al.
Nicolas Diotel et al.
Unlike that of mammals, the brain of teleost fish exhibits an intense aromatase activity due to the strong expression of one of two aromatase genes (aromatase A or cyp19a1a and aromatase B or cyp19a1b) that arose from a gene duplication eve...
Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs [0.03%]
下丘脑促甲状腺激素释放激素神经元的调控：来自神经和外周的输入
Eduardo A Nillni
Eduardo A Nillni
The hypothalamic-pituitary-thyroid (HPT) axis plays a critical role in mediating changes in metabolism and thermogenesis. Thus, the central regulation of the thyroid axis by Thyrotropin Releasing Hormone (TRH) neurons in the paraventricular...
T R Castañeda,J Tong,R Datta et al.
T R Castañeda et al.
Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a potent stimulator of growth hormone (GH) secretion and is the only circulator...
Martin G Myers Jr,Richard B Simerly
Martin G Myers Jr
Nandakumar S Narayanan,Douglas J Guarnieri,Ralph J DiLeone
Nandakumar S Narayanan
Recent evidence has emerged demonstrating that metabolic hormones such as ghrelin and leptin can act on ventral tegmental area (VTA) midbrain dopamine neurons to influence feeding. The VTA is the origin of mesolimbic dopamine neurons that p...
Harvey J Grill
Harvey J Grill
The development of effective pharmacotherapy for obesity will benefit from a more complete understanding of the neural pathways and the neurochemical signals whose actions result in the reduction of the size of meals. This review examines t...
Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation [0.03%]
脑中的甜言蜜语：葡萄糖感受、神经网络和低血糖的反调节作用
Alan G Watts,Casey M Donovan
Alan G Watts
Glucose is the primary fuel for the vast majority of cells, and animals have evolved essential cellular, autonomic, endocrine, and behavioral measures to counteract both hypo- and hyperglycemia. A central component of these counterregulator...
Critical determinants of hypothalamic appetitive neuropeptide development and expression: species considerations [0.03%]
决定下丘脑摄食神经肽发育和表达的关键因素：物种的考虑事项
B E Grayson,P Kievit,M S Smith et al.
B E Grayson et al.
Over the last decade there has been a striking increase in the early onset of metabolic disease, including obesity and diabetes. The regulation of energy homeostasis is complex and involves the intricate integration of peripheral and centra...