Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance [0.03%]
二噁英、芳香烃受体与能量平衡的中枢调控
Jere Lindén,Sanna Lensu,Jouko Tuomisto et al.
Jere Lindén et al.
Dioxins are ubiquitous environmental contaminants that have attracted toxicological interest not only for the potential risk they pose to human health but also because of their unique mechanism of action. This mechanism involves a specific,...
Chemokines and chemokine receptors: new actors in neuroendocrine regulations [0.03%]
趋化因子和趋化因子受体：神经内分泌调节中的新角色
William Rostène,Alice Guyon,Lara Kular et al.
William Rostène et al.
Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells. Their role in the immune system is well-known, and it has recently been suggested that they may also play a role in the central nervous syste...
Tibor Hajszan,Csaba Leranth
Tibor Hajszan
The potential adverse effects of Bisphenol A (BPA), a synthetic xenoestrogen, have long been debated. Although standard toxicology tests have revealed no harmful effects, recent research highlighted what was missed so far: BPA-induced alter...
Neuroendocrine actions of organohalogens: thyroid hormones, arginine vasopressin, and neuroplasticity [0.03%]
有机卤素的神经内分泌作用：甲状腺激素、精氨酸血管加压素和神经可塑性
Prasada Rao S Kodavanti,Margarita C Curras-Collazo
Prasada Rao S Kodavanti
Organohalogen compounds are global environmental pollutants. They are highly persistent, bioaccumulative, and cause adverse effects in humans and wildlife. Because of the widespread use of these organohalogens in household items and consume...
Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective [0.03%]
环境内分泌干扰物的表观遗传效应及其对女性生殖的影响：卵巢视角
Aparna Mahakali Zama,Mehmet Uzumcu
Aparna Mahakali Zama
The link between in utero and neonatal exposure to environmental toxicants, such as endocrine-disrupting chemicals (EDCs) and adult female reproductive disorders is well established in both epidemiological and animal studies. Recent studies...
Tina A Dardeno,Sharon H Chou,Hyun-Seuk Moon et al.
Tina A Dardeno et al.
Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent "proof of concept" clinical trials usi...
Christine L Jasoni,Nicola Romanò,Stephanie Constantin et al.
Christine L Jasoni et al.
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of the neuronal network controlling fertility. Intracellular calcium ion concentration ([Ca(2+)](i)) is likely to be a key signaling tool used by GnRH neurons ...
Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction [0.03%]
加压素样肽（GALP）是下丘脑能量平衡和生殖调节因子
Catherine Lawrence,Gregory S Fraley
Catherine Lawrence
Galanin-like peptide (GALP) was discovered in 1999 in the porcine hypothalamus and was found to be a 60 amino acid neuropeptide. GALP shares sequence homology to galanin (1-13) in position 9-21 and can bind to, as well as activate, the thre...
Function-related structural plasticity of the GnRH system: a role for neuronal-glial-endothelial interactions [0.03%]
与功能相关的GnRH系统的结构性可塑性：神经元-胶质细胞-内皮细胞相互作用的作用
Vincent Prevot,Naresh K Hanchate,Nicole Bellefontaine et al.
Vincent Prevot et al.
As the final common pathway for the central control of gonadotropin secretion, GnRH neurons are subjected to numerous regulatory homeostatic and external factors to achieve levels of fertility appropriate to the organism. The GnRH system th...
Baby on board: do responses to stress in the maternal brain mediate adverse pregnancy outcome? [0.03%]
谈笑风“孕”——母亲大脑对压力的反应介导不良妊娠结局？
Alison J Douglas
Alison J Douglas
Stress and adverse environmental surroundings result in suboptimal conditions in a pregnant mother such that she may experience poor pregnancy outcome including complete pregnancy failure and preterm labor. Furthermore her developing baby i...