Metabolic Drivers of Alzheimer's Disease: Integrating brain Hypometabolism, insulin Resistance, and systemic dysregulation [0.03%]
阿尔茨海默病的代谢驱动因素：整合脑低代谢、胰岛素抵抗和全身失调
Vicko Suswidiantoro,Kim San Tang,Khalid Rahman et al.
Vicko Suswidiantoro et al.
The repeated failure of amyloid therapies highlights a core misunderstanding of Alzheimer's disease (AD) origins. A new metabolic paradigm now positions impaired brain metabolism-not protein accumulation-as the central, early driver. Key ev...
The microbiota-gut-brain axis in Huntington's disease: Evidence, mechanisms and therapeutic opportunities [0.03%]
亨廷顿舞蹈病中的微生态-肠-脑轴：证据、机制及治疗机会
Yuxiu Gu,Mingxiao Wang,Ying Mao
Yuxiu Gu
Huntington's disease (HD) is increasingly recognized as a multisystem disorder in which perturbations of the gut microbiota may influence peripheral homeostasis and shape central neurodegeneration. Across human cohorts, HD is marked by repr...
Associations of cortisol with Alzheimer's disease fluid and neuroimaging biomarkers: A systematic review [0.03%]
皮质醇与阿尔茨海默病体液和影像学生物标志物关联性的系统综述
Jasper Holleman,Sima Toopchiani,Oliver Robinson et al.
Jasper Holleman et al.
Background: Chronic stress triggers the dysregulation of hypothalamic-pituitary-adrenal (HPA) axis which is characterized by altered diurnal cortisol patterns and increased basal cortisol levels. This dysregulation has be...
A Consequential misattribution error in Sanchis-Segura, Forn, and Wilcox (2026) [0.03%]
桑契斯-塞古拉、福尔和威尔科克斯(2026)文章中的一个重要误归因错误
Donald B Macnaughton
Donald B Macnaughton
This comment identifies an error in an article by Sanchis-Segura, Forn, and Wilcox in which a controversial editorial in the American Statistician was mistakenly interpreted as a policy statement of the American Statistical Association and ...
Not just neurons: Glial mechanisms driving sex-specific vulnerability to withdrawal and relapse in substance use disorder [0.03%]
不只是神经元：物质使用障碍中性别特异性戒断和复发的星形胶质细胞机制
Nicole Horan,Tori Keefauver,Marianne L Seney
Nicole Horan
Sex differences are fundamental determinants of the neurobiology of substance use disorders (SUDs), modulating withdrawal severity, relapse risk, and treatment response. Despite this, prior research has largely studied males and ignored sex...
Orexin signaling across the female lifespan: developmental, reproductive, and aging perspectives from humans and animal models [0.03%]
催产素信号的生命周期变化：来自人类和动物模型的发展、生殖和衰老观点
Katarzyna Kirsz,Dorota A Zięba
Katarzyna Kirsz
Orexin-A and orexin-B are hypothalamic neuropeptides that coordinate arousal, metabolic, and reproductive functions through orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). This review synthesizes evidence from humans, experimental mo...
The importance of ovary-immune interactions in the context of age and disease [0.03%]
卵巢与免疫相互作用的年龄和疾病背景下的重要性分析
Macy E Zardeneta,Kaylin A Pickle,Farida Sohrabji
Macy E Zardeneta
The ovary, a dynamic endocrine organ, plays a central role in female reproductive function through the secretion of hormones such as 17β-estradiol, progesterone, testosterone, and inhibin. Beyond its endocrine activity, the ovary serves as...
From menarche to menopause: estrogenic influences on stroke-related depression in women [0.03%]
从初潮到绝经：雌激素对女性卒中相关抑郁的影响
Lauren Kelly Tierney,Indy Cabeda Diaz,Shahil H Patel et al.
Lauren Kelly Tierney et al.
Post-stroke depression (PSD) is a common and debilitating complication that disproportionately affects women, yet the underlying risk factors remain incompletely understood. Hormonal fluctuations across a woman's lifespan, including those n...
Pathogenesis and potential therapies for perimenopausal depression: Insights from the estrogen-gut microbiota axis [0.03%]
围绝经期抑郁的发病机制及潜在治疗策略：来自雌激素-肠道微生物轴的启示
Xuli Wang,Yudong Lin,Mingmei Zhou
Xuli Wang
Perimenopause represents a critical phase during which women are particularly susceptible to depression. Although fluctuations in estrogen levels resulting from ovarian aging and imbalances in the gut microbiota have been identified as cont...
We must look beyond primary reinforcement to understand nicotine use in women [0.03%]
我们必须超越初级强化来理解女性的尼古丁使用行为
Kathleen R McNealy,Scott T Barrett,Rick A Bevins
Kathleen R McNealy
Women exhibit greater nicotine use vulnerability than men. Common cessation treatments are less effective for women, suggesting unique contributors to women's smoking that are not fully characterized or targeted by available treatments. Hig...