Stressful development: integrating endoderm development, stress, and longevity [0.03%]
压力与发育：内胚层发育、应对压力及寿命延长之间的关系
Chee Kiang Ewe,Geneva Alok,Joel H Rothman
Chee Kiang Ewe
In addition to performing digestion and nutrient absorption, the intestine serves as one of the first barriers to the external environment, crucial for protecting the host from environmental toxins, pathogenic invaders, and other stress ind...
Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b [0.03%]
喉中线的形成依赖Hox基因的作用——斑马鱼实验研究
Gökhan Dalgin,Victoria E Prince
Gökhan Dalgin
During vertebrate embryonic development complex morphogenetic events drive the formation of internal organs associated with the developing digestive tract. The foregut organs derive from hepatopancreatic precursor cells that originate bilat...
Postembryonic screen for mutations affecting spine development in zebrafish [0.03%]
斑马鱼突变体后胚胎筛检及其脊神经发育缺陷表型
Ryan S Gray,Roberto Gonzalez,Sarah D Ackerman et al.
Ryan S Gray et al.
The spine gives structural support for the adult body, protects the spinal cord, and provides muscle attachment for moving through the environment. The development and maturation of the spine and its physiology involve the integration of mu...
Sun K Kim,Eva Brotslaw,Virginie Thome et al.
Sun K Kim et al.
Centriole amplification in multiciliated cells occurs in a pseudo-cell cycle regulated process that typically utilizes a poorly characterized molecularly dense structure called the deuterosome. We identified the centrosomal protein Cep70 as...
Hanieh Falahati,Woonyung Hur,Stefano Di Talia et al.
Hanieh Falahati et al.
The early stages of development involve complex sequences of morphological changes that are both reproducible from embryo to embryo and often robust to environmental variability. To investigate the relationship between reproducibility and r...
Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis [0.03%]
果蝇crinkled/肌球蛋白VIIA突变影响毛的形态发生
Jennifer L Sallee,Janice M Crawford,Vinay Singh et al.
Jennifer L Sallee et al.
Actin filament crosslinking, bundling and molecular motor proteins are necessary for the assembly of epithelial projections such as microvilli, stereocilia, hairs, and bristles. Mutations in such proteins cause defects in the shape, structu...
Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture [0.03%]
Smad4在Scleraxis谱系细胞中的丢失导致关节屈曲挛缩症
Saundra Y Schlesinger,Seongkyung Seo,Brian A Pryce et al.
Saundra Y Schlesinger et al.
Growth of the musculoskeletal system requires precise coordination between bone, muscle, and tendon during development. Insufficient elongation of the muscle-tendon unit relative to bone growth results in joint contracture, a condition char...
Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle [0.03%]
Mef2c因子要求早期但不是晚期心室心肌细胞的添加
Duvaraka Kula-Alwar,Michael S Marber,Simon M Hughes et al.
Duvaraka Kula-Alwar et al.
During heart formation, the heart grows and undergoes dramatic morphogenesis to achieve efficient embryonic function. Both in fish and amniotes, much of the growth occurring after initial heart tube formation arises from second heart field ...
BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo [0.03%]
bmp信号在小鼠胚胎着床前后过渡期间的额外胚层发育中是必需的
Berna Sozen,Necdet Demir,Magdalena Zernicka-Goetz
Berna Sozen
At implantation, the mouse embryo undergoes a critical transformation which requires the precise spatiotemporal control of signalling pathways necessary for morphogenesis and developmental progression. The role played by such signalling pat...
Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP) [0.03%]
FOP中原肌球蛋白受体激酶ACVR1信号异常通过骨形态发生蛋白信号途径损害指关节的发育
O Will Towler,Sun H Peck,Frederick S Kaplan et al.
O Will Towler et al.
The development of joints in the mammalian skeleton depends on the precise regulation of multiple interacting signaling pathways including the bone morphogenetic protein (BMP) pathway, a key regulator of joint development, digit patterning,...