Physiological electric fields induce directional migration of mammalian cranial neural crest cells [0.03%]
生理电场诱导颅神经crest细胞定向迁移
Abijeet Singh Mehta,Pin Ha,Kan Zhu et al.
Abijeet Singh Mehta et al.
During neurulation, cranial neural crest cells (CNCCs) migrate long distances from the neural tube to their terminal site of differentiation. The pathway traveled by the CNCCs defines the blueprint for craniofacial construction, abnormaliti...
Modeling human embryo development with embryonic and extra-embryonic stem cells [0.03%]
用胚胎和副胚层干细胞模拟人类胚胎发育
Bailey A T Weatherbee,Tongtong Cui,Magdalena Zernicka-Goetz
Bailey A T Weatherbee
Early human post-implantation development involves extensive growth combined with a series of complex morphogenetic events. The lack of precise spatial and temporal control over these processes leads to pregnancy loss. Given the ethical and...
Melissa H Little
Melissa H Little
There is no doubt that the development of transplantable synthetic kidneys could improve the outcome for the many millions of people worldwide suffering from chronic kidney disease. Substantial progress has been made in the last 6 years in ...
The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking [0.03%]
基于干细胞的胚胎学中的形态发生动力学：对破缺对称性的新认识
Berna Sozen,Jake Cornwall-Scoones,Magdalena Zernicka-Goetz
Berna Sozen
Breaking embryonic symmetry is an essential prerequisite to shape the initially symmetric embryo into a highly organized body plan that serves as the blueprint of the adult organism. This critical process is driven by morphogen signaling gr...
Interdependent regulation of stereotyped and stochastic photoreceptor fates in the fly eye [0.03%]
果蝇眼睛中立体视觉和随机视觉的感受器相互依存的调节机制
Adam C Miller,Elizabeth A Urban,Eric L Lyons et al.
Adam C Miller et al.
Diversification of neuronal subtypes often requires stochastic gene regulatory mechanisms. How stochastically expressed transcription factors interact with other regulators in gene networks to specify cell fates is poorly understood. The ra...
Taste buds are not derived from neural crest in mouse, chicken, and zebrafish [0.03%]
小鼠、鸡和斑马鱼的味蕾并非由神经嵴细胞分化产生
Wenxin Yu,Zhonghou Wang,Brett Marshall et al.
Wenxin Yu et al.
Our lineage tracing studies using multiple Cre mouse lines showed a concurrent labeling of abundant taste bud cells and the underlying connective tissue with a neural crest (NC) origin, warranting a further examination on the issue of wheth...
Justyna Jedrychowska,Eugene V Gasanov,Vladimir Korzh
Justyna Jedrychowska
The function of the inner ear depends on the maintenance of high concentrations of K+ ions. The slow-inactivating delayed rectifier Kv2.1/KCNB1 channel works in the inner ear in mammals. The kcnb1 gene is expressed in the otic vesicle of de...
Sox10-cre BAC transgenes reveal temporal restriction of mesenchymal cranial neural crest and identify glandular Sox10 expression [0.03%]
SOX10- cre BAC 基因揭示了间充质颅神经 crest的时空限制，并确定了腺体SOX10表达
Karen K Deal,Jennifer C Rosebrock,Angela M Eeds et al.
Karen K Deal et al.
Diversity of neural crest derivatives has been studied with a variety of approaches during embryonic development. In mammals Cre-LoxP lineage tracing is a robust means to fate map neural crest relying on cre driven from regulatory elements ...
Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts [0.03%]
斑马鱼心脏再生是“完全的”吗？心肌细胞增殖恢复到损伤前的数量，但瘢痕心中部分未能分化
Alberto Bertozzi,Chi-Chung Wu,Phong D Nguyen et al.
Alberto Bertozzi et al.
Adult zebrafish are frequently described to be able to "completely" regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since existing evidence for cardiomyocyte proliferation is indirect or...
Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo [0.03%]
多组织模式塑造秀丽隐杆线虫胚胎的头部形态发生过程
Stéphanie Grimbert,Karina Mastronardi,Victoria Richard et al.
Stéphanie Grimbert et al.
Complex structures derived from multiple tissue types are challenging to study in vivo, and our knowledge of how cells from different tissues are coordinated is limited. Model organisms have proven invaluable for improving our understanding...