Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm [0.03%]
ABCB、ABCC和ABCG转运蛋白的早期模式化在胚胎中胚层和内胚层建立了小分子转运的独特区域
Catherine S Schrankel,Amro Hamdoun
Catherine S Schrankel
Directed intercellular movement of diverse small molecules, including metabolites, signal molecules and xenobiotics, is a key feature of multicellularity. Networks of small molecule transporters (SMTs), including several ATP Binding Cassett...
GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans [0.03%]
GRDN-1/Girdin调节C. elegans中两种特化感觉神经元的树突形态发生和纤毛位置
Inna Nechipurenko,Sofia Lavrentyeva,Piali Sengupta
Inna Nechipurenko
Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli. The mechanisms that coordinate dendrite extension with cilium position during ...
Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development [0.03%]
异常的门齿形态表明Tfap2a和Tfap2b在牙齿发育中具有组织特异性的功能
Emily D Woodruff,Galaxy C Gutierrez,Eric Van Otterloo et al.
Emily D Woodruff et al.
Mice possess two types of teeth that differ in their cusp patterns; incisors have one cusp and molars have multiple cusps. The patterning of these two types of teeth relies on fine-tuning of the reciprocal molecular signaling between dental...
ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes [0.03%]
ETS转录因子对于不同类型内皮细胞中增强子活化的特异性模式而言是必要而非充分的
Alice Neal,Svanhild Nornes,Pakavarin Louphrasitthiphol et al.
Alice Neal et al.
Correct vascular differentiation requires distinct patterns of gene expression in different subtypes of endothelial cells. Members of the ETS transcription factor family are essential for the transcriptional activation of arterial and angio...
The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish [0.03%]
FGF-AKT信号通路是斑马鱼心脏再生性心肌细胞存活所必需的
Naoyuki Tahara,Ryutaro Akiyama,Justin Wang et al.
Naoyuki Tahara et al.
Zebrafish have a remarkable ability to regenerate the myocardium after injury by proliferation of pre-existing cardiomyocytes. Fibroblast growth factor (FGF) signaling is known to play a critical role in zebrafish heart regeneration through...
Bernadett Bosze,Julissa Suarez-Navarro,Abdul Soofi et al.
Bernadett Bosze et al.
The vertebrate eye anlage grows out of the brain and folds into bilayered optic cups. The eye is patterned along multiple axes, precisely controlled by genetic programs, to delineate neural retina, pigment epithelium, and optic stalk tissue...
YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance [0.03%]
YAP1及其融合蛋白在癌症发生、发展及治疗抗性中的作用
Frank Szulzewsky,Eric C Holland,Valeri Vasioukhin
Frank Szulzewsky
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway. In addition to important functions in normal tissue homeostasis and regeneration, YAP1 has also prominent functions in cancer initiation, ag...
A globin-family protein, Cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish [0.03%]
视黄醇结合蛋白参与斑马鱼神经嵴源性组织和器官的发育
Kazuki Takahashi,Yuki Ito,Mami Yoshimura et al.
Kazuki Takahashi et al.
The zebrafish is an excellent model animal that is amenable to forward genetics approaches. To uncover unknown developmental regulatory mechanisms in vertebrates, we conducted chemical mutagenesis screening and identified a novel mutation, ...
Reassembling gastrulation [0.03%]
重构原肠胚形成过程
Alexandra Schauer,Carl-Philipp Heisenberg
Alexandra Schauer
During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to...
Jesse V Veenvliet,Bernhard G Herrmann
Jesse V Veenvliet
Mammalian post-implantation development comprises the coordination of complex lineage decisions and morphogenetic processes shaping the embryo. Despite technological advances, a comprehensive understanding of the dynamics of these processes...