Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis [0.03%]
Lats1和Lats2失活强调了Hippo途径效应物YAP在喉和声带上皮形态发生中的作用
Vidisha Mohad,Vlasta Lungova,Jamie Verheyden et al.
Vidisha Mohad et al.
Proliferation and differentiation of vocal fold epithelial cells during embryonic development is poorly understood. We examined the role of Hippo signaling, a vital pathway known for regulating organ size, in murine laryngeal development. C...
The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging [0.03%]
保守的可变剪接因子caper通过调节发育和衰老期间的神经肌肉表型发挥功能
M Brandon Titus,Ethan G Wright,Jeremy M Bono et al.
M Brandon Titus et al.
RNA-binding proteins play an important role in the regulation of post-transcriptional gene expression throughout the nervous system. This is underscored by the prevalence of mutations in genes encoding RNA splicing factors and other RNA-bin...
The development of sex differences in the nervous system and behavior of flies, worms, and rodents [0.03%]
从flies、worms到rodents的神经系统和行为差异的发展性研究进展
Kristen L Meeh,Clare T Rickel,Alexander J Sansano et al.
Kristen L Meeh et al.
Understanding how sex differences in innate animal behaviors arise has long fascinated biologists. As a general rule, the potential for sex differences in behavior is built by the developmental actions of sex-specific hormones or regulatory...
Coup-TF: A maternal factor essential for differentiation along the embryonic axes in the sea urchin Paracentrotus lividus [0.03%]
海胆卵裂轴建立的重要母源因子COUP-TF
Ioannis Tsironis,Periklis Paganos,Georgia Gouvi et al.
Ioannis Tsironis et al.
Coup-TF, a member of the nuclear receptor super-family, is present in the pool of maternal mRNAs and proteins in the sea urchin egg. The presence of this protein seems to be essential for the execution of the early developmental program, le...
Sabitri Ghimire,Veronika Mantziou,Naomi Moris et al.
Sabitri Ghimire et al.
Technical and ethical limitations create a challenge to study early human development, especially following the first 3 weeks of development after fertilization, when the fundamental aspects of the body plan are established through the proc...
Nutrient availability contributes to a graded refractory period for regeneration in Xenopus tropicalis [0.03%]
营养可得性有助于Xenopus tropicalis再生的分级迟缓期
Madison C Williams,Jeet H Patel,Anneke D Kakebeen et al.
Madison C Williams et al.
Xenopus tadpoles are a unique model for regeneration in that they exhibit two distinct phases of age-specific regenerative competence. In Xenopus laevis, young tadpoles fully regenerate following major injuries such as tail transection, the...
microRNA-31 regulates skeletogenesis by direct suppression of Eve and Wnt1 [0.03%]
微小核糖核酸-31通过直接抑制Eve和Wnt1调控骨发生作用
Nina Faye Sampilo,Nadezda A Stepicheva,Jia L Song
Nina Faye Sampilo
microRNAs (miRNAs) play a critical role in a variety of biological processes, including embryogenesis and the physiological functions of cells. Evolutionarily conserved microRNA-31 (miR-31) has been found to be involved in cancer, bone form...
Anterior lateral plate mesoderm gives rise to multiple tissues and requires tbx5a function in left-right asymmetry, migration dynamics, and cell specification of late-addition cardiac cells [0.03%]
前侧板中胚层产生多种组织，并且需要tbx5a在左右不对称性、迁移动力学和心脏细胞中的作用。
Lindsey M F Mao,Erin A T Boyle Anderson,Robert K Ho
Lindsey M F Mao
In this study, we elucidate a single cell resolution fate map in the zebrafish in a sub-section of the anterior Lateral Plate Mesoderm (aLPM) at 18 hpf. Our results show that this tissue is not organized into segregated regions but gives ri...
CRISPR-Cas9 editing of non-coding genomic loci as a means of controlling gene expression in the sea urchin [0.03%]
利用CRISPR-Cas9编辑海胆非编码基因组区域以控制基因表达的方法
Alice Pieplow,Meseret Dastaw,Tetsushi Sakuma et al.
Alice Pieplow et al.
We seek to manipulate gene function here through CRISPR-Cas9 editing of cis-regulatory sequences, rather than the more typical mutation of coding regions. This approach would minimize secondary effects of cellular responses to nonsense medi...
Synthetic by design: Exploiting tissue self-organization to explore early human embryology [0.03%]
设计合成：利用组织自我组织来探索早期人类胚胎学
Edwin A Rosado-Olivieri,Ali H Brivanlou
Edwin A Rosado-Olivieri
Recent advances in synthetic human embryology has provided a previously inexistent molecular portrait of human development. Models of synthetic human embryonic tissues capitalize on the self-organizing capabilities of human embryonic stem c...