Mary Jo Talley,Diana Nardini,Shenyue Qin et al.
Mary Jo Talley et al.
The MAPK pathway is a major growth signal that has been implicated during the development of progenitors, neurons, and glia in the embryonic brain. Here, we show that the MAPK pathway plays an important role in the generation of distinct ce...
Ginés Morata
Ginés Morata
Cell competition is a homeostatic process designed to remove from animal tissues viable cells that are unfit, abnormal or malignant and that may compromise the general fitness or the viability of the organism. Originally discovered in Droso...
Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis [0.03%]
细胞竞争诱导的转化细胞顶侧消除机制(EDAC)协调细胞稳态
Shunsuke Kon,Yasuyuki Fujita
Shunsuke Kon
Newly emerging transformed cells are often eliminated from the epithelium via cell competition with the surrounding normal cells. A number of recent studies using mammalian cell competition systems have demonstrated that cells with various ...
Early cis-regulatory events in the formation of retinal horizontal cells [0.03%]
视网膜水平细胞形成过程中的早期顺式调控事件
Estie Schick,Kevin C Gonzalez,Pooja Dutta et al.
Estie Schick et al.
During retinal development, multipotent and restricted progenitor cells generate all of the neuronal cells of the retina. Among these are horizontal cells, which are interneurons that modulate the light-induced signal from photoreceptors. T...
CREB-binding protein (CBP) gene family regulates planarian survival and stem cell differentiation [0.03%]
CREB结合蛋白(CBP)基因家族调控涡虫存活和干细胞分化
Susanna Fraguas,Sheila Cárcel,Coral Vivancos et al.
Susanna Fraguas et al.
In developmental biology, the regulation of stem cell plasticity and differentiation remains an open question. CBP(CREB-binding protein)/p300 is a conserved gene family that functions as a transcriptional co-activator and plays important ro...
Mechanisms of vitamin A metabolism and deficiency in the mammalian and fly visual system [0.03%]
维生素A代谢及缺乏在哺乳动物和果蝇视系统中的机制研究
Deepshe Dewett,Khanh Lam-Kamath,Clara Poupault et al.
Deepshe Dewett et al.
Vitamin A deficiency can cause human pathologies that range from blindness to embryonic malformations. This diversity is due to the lack of two major vitamin A metabolites with very different functions: the chromophore 11-cis-retinal (vitam...
HAND transcription factors cooperatively specify the aorta and pulmonary trunk [0.03%]
HAND转录因子协同确定主动脉和肺动脉的位置
Joshua W Vincentz,Beth A Firulli,Kevin P Toolan et al.
Joshua W Vincentz et al.
Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant cause of morbidity and mortality. The OFT develops from migratory cell populations which include the cardiac neural crest cells (cNCCs) and s...
Cis-regulatory code for determining the action of Foxd as both an activator and a repressor in ascidian embryos [0.03%]
文昌鱼胚胎中Foxd作为激活因子和抑制因子的作用机制的顺式调控密码
Shinichi Tokuhiro,Yutaka Satou
Shinichi Tokuhiro
In early embryos of Ciona, an invertebrate chordate, the animal-vegetal axis is established by the combinatorial actions of maternal factors. One target of these maternal factors, Foxd, is specifically expressed in the vegetal hemisphere an...
Unifying synthetic embryology [0.03%]
统一合成胚胎学
Jake Cornwall-Scoones,Magdalena Zernicka-Goetz
Jake Cornwall-Scoones
Mariana Marques-Reis,Eduardo Moreno
Mariana Marques-Reis
Recent advances in rapid medical detection and diagnostic technology have extended both human health and life expectancy. However, ageing remains one of the critical risk factors in contributing to major incapacitating and fatal conditions,...