Santosh Kumar Maharana,Jean-Pierre Saint-Jeannet
Santosh Kumar Maharana
Nager syndrome is a rare human developmental disorder characterized by hypoplastic neural crest-derived craniofacial bones and limb defects. Mutations in SF3B4 gene, which encodes a component of the spliceosome, are a major cause for Nager....
Cardiomyocyte heterogeneity during zebrafish development and regeneration [0.03%]
斑马鱼心脏发育和再生过程中心肌细胞的异质性研究
Ayele Taddese Tsedeke,Srinivas Allanki,Alessandra Gentile et al.
Ayele Taddese Tsedeke et al.
Contrary to adult mammals, zebrafish are able to regenerate their heart after cardiac injury. This regenerative response relies, in part, on the endogenous ability of cardiomyocytes (CMs) to dedifferentiate and proliferate to replenish the ...
Elizabeth T Ables,Alissa R Armstrong
Elizabeth T Ables
Courtney A Burger,Danye Jiang,Robert D Mackin et al.
Courtney A Burger et al.
Synapses in the outer retina are the first information relay points in vision. Here, photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal cells. Because outer retina synapses are particularly large and h...
Insulator foci distance correlates with cellular and nuclear morphology in early Drosophila embryos [0.03%]
绝缘子焦点距离与早期果蝇胚胎中的细胞和核形态相关
Mo Li,Qing Zhao,Ryan Belloli et al.
Mo Li et al.
The three-dimensional (3D) organization of the genome is highly dynamic, changing during development and varying across different tissues and cell types. Recent studies indicate that these changes alter regulatory interactions, leading to c...
Altered sacral neural crest development in Pax3 spina bifida mutants underlies deficits of bladder innervation and function [0.03%]
Pax3基因脊柱裂突变体中变异的尾神经嵴发育导致膀胱支配缺陷和功能障碍
Karen K Deal,Anoop S Chandrashekar,M Makenzie Beaman et al.
Karen K Deal et al.
Mouse models of Spina bifida (SB) have been instrumental for identifying genes, developmental processes, and environmental factors that influence neurulation and neural tube closure. Beyond the prominent neural tube defects, other aspects o...
Fish models for investigating nutritional regulation of embryonic development [0.03%]
鱼类模型在研究营养与胚胎发育关系中的应用
Misty R Riddle,Chi-Kuo Hu
Misty R Riddle
In recent decades, biologist have focused on the spatiotemporal regulation and function of genes to understand embryogenesis. It is clear that maternal diet impacts fetal development but how nutrients, like lipids and vitamins, modify devel...
The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development [0.03%]
Kunitz型丝氨酸蛋白酶抑制剂Spint2在斑马鱼孵化腺发育过程中对于细胞连接、协调的细胞迁移和细胞存活是必不可少的
Julia Hatzold,Heike Wessendorf,Hans-Martin Pogoda et al.
Julia Hatzold et al.
We have previously shown that the Kunitz-type serine protease inhibitor Spint1a, also named Hai1a, is required in the zebrafish embryonic epidermis to restrict the activity of the type II transmembrane serine protease (TTSP) Matriptase1a/St...
Build me up optic cup: Intrinsic and extrinsic mechanisms of vertebrate eye morphogenesis [0.03%]
构建我吧光学杯：脊椎动物眼睛形态发生的固有和非固有机制
Macaulie A Casey,Sarah Lusk,Kristen M Kwan
Macaulie A Casey
The basic structure of the eye, which is crucial for visual function, is established during the embryonic process of optic cup morphogenesis. Molecular pathways of specification and patterning are integrated with spatially distinct cell and...
Different roles for the adjoining and structurally similar A-rich and poly(A) domains of oskar mRNA: Only the A-rich domain is required for oskar noncoding RNA function, which includes MTOC positioning [0.03%]
富A区和多聚腺苷酸区域在oskar mRNA的临近结构和功能中的不同作用：只有富A区对于oskar非编码RNA的功能是必需的，其功能包括微管组织中心定位
Andrew Kenny,Miles B Morgan,Paul M Macdonald
Andrew Kenny
Drosophila oskar (osk) mRNA has both coding and noncoding functions, with the latter required for progression through oogenesis. Noncoding activity is mediated by the osk 3' UTR. Three types of cis elements act most directly and are cluster...