Dynamic remodeling of epithelial junctions in trophoblast cells of the mammalian blastocyst [0.03%]
哺乳动物囊胚滋养层细胞上皮连接的动态重塑
Xinjian Doris He,Caroline McCaffrey,Kimberly D Tremblay et al.
Xinjian Doris He et al.
Proper junction organization within the trophectoderm is essential for blastocyst integrity and implantation. Epithelial junctions are well characterized in many somatic cell types with a typical apical-basal arrangement of junction type: t...
Foxg1 regulates the development of microvillous cells in the olfactory epithelium [0.03%]
Foxg1调控嗅上皮微绒毛细胞的发育
Sarah K Christian,Laylah Liwaru,Nusaybah Ibrahim et al.
Sarah K Christian et al.
Foxg1 is a transcription factor that plays important roles in the development of the nervous and sensory systems. In the olfactory epithelium, it is known that Foxg1 is necessary for the development of subsets of olfactory sensory neurons, ...
Differences in Cellular mechanics and ECM dynamics shape differential development of wing and haltere in Drosophila [0.03%]
细胞力学和基质动力学的差异塑造了果蝇翅膀和平衡棒的不同发育过程
C Dilsha,Salima Shiju,Neel Ajay Shah et al.
C Dilsha et al.
Diverse organ shapes and sizes arise from the complex interplay between cellular properties, mechanical forces, and gene regulation. Drosophila wing- a flat structure and the globular haltere are two homologous flight appendages emerging fr...
The dynamic landscape of alternative 3' UTR during mammalian preimplantation development [0.03%]
哺乳动物植入前发育期间替代3'UTR的动态景观
Yu Zhang,Anqi Li,Jieyu Wu et al.
Yu Zhang et al.
Alternative polyadenylation (APA) generates mRNA isoforms with distinct 3' UTR lengths, yet its role in mammalian preimplantation development remains largely unexplored. Here, we systematically delineated single-cell 3' UTR APA dynamics in ...
A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development [0.03%]
颅面发育过程中调控Alx1基因表达和功能的一个关键的Twist1调节的远端增强子元件
Yilun Huang,Paul P R Iyyanar,Jingyue Xu et al.
Yilun Huang et al.
Disruption of ALX1 causes frontonasal dysplasia syndrome-3, characterized by extreme microphthalmia, severe midfacial hypoplasia, and orofacial clefting. Recent studies have revealed critical tissue-specific roles of ALX1 in patterning both...
Chick gonad explant electroporation reveals enhancers for testes determining factor, DMRT1 [0.03%]
鸡生殖腺电穿孔实验揭示了性别决定基因DMRT1的增强子元件
Zane Oberholzer,Güneş Taylor,Dorit Hockman et al.
Zane Oberholzer et al.
Enhancers are key regulatory elements that coordinate precise spatio-temporal gene expression during embryonic development. In this study, we used the chick to investigate the regulatory landscape of the highly conserved transcription facto...
Danielle J Gardon,Che-Jui Liu,Natalia A Veniaminova et al.
Danielle J Gardon et al.
Meibomian glands (MGs) in the eyelid secrete lipids that stabilize the tear film and protect the ocular surface. Abnormal MGs are associated with dry eye disease (DED), one of the most common ophthalmological disorders, but the molecular al...
Discrete 3' UTR sequence motifs regulate nanos RNA enrichment in Drosophila germ granules [0.03%]
离散的3'UTR序列基元调节NanosRNA在果蝇原生质颗粒中的富集作用
Kira Mitchel,Elizabeth R Gavis
Kira Mitchel
Germ granules are ribonucleoprotein condensates that concentrate key maternal mRNAs needed for germ cell development. In Drosophila, nanos mRNA is selectively enriched in germ granules but the specific cis-acting elements mediating this pro...
The roles of TGFβ and serotonin signaling in regulation of germline progenitors in adult C. elegans hermaphrodites revealed by the effects of a male pheromone [0.03%]
通过雄性信息素影响揭示秀丽隐杆线虫成年雌雄同体生殖干细胞调控中的TGFβ和血清素信号的作用
Erin Z Aprison,Svetlana Dzitoyeva,Ilya Ruvinsky
Erin Z Aprison
Some developmental processes initiated in embryos or larvae persist into adulthood, a prominent example being maintenance of stem cells. To what extent are the mechanisms regulating these cell populations similar during different stages of ...
Madison Zitting,Zhou Yu,Ting-Xin Jiang et al.
Madison Zitting et al.
Bioelectricity plays a key role in shaping tissues during early development. We previously demonstrated that elongating chicken feather buds establish a transient standing electrical current loop, with calcium channel-mediated inward curren...