Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia [0.03%]
哺乳动物前脑和神经原初纤毛的正常发育需要微管结合蛋白Togaram1
Clarissa Q Nassar,Savera J Shetty,Noelle D Dwyer
Clarissa Q Nassar
Proper forebrain development relies on precise spatial and temporal control of early neural stem cell (NSC) proliferation and later neurogenesis. Brain malformations can arise when these processes are defective. Joubert Syndrome (JS) is a n...
Imbalanced neurogenesis and gliogenesis in the developing neocortex of mice lacking the proteoglycan Tsukushi [0.03%]
缺失蛋白多糖Tsukushi的小鼠新皮层神经发生和少突胶质发生的不平衡
Sabrina Quaresima,Valerio Licursi,Tenta Ohkubo et al.
Sabrina Quaresima et al.
Development of the mammalian neocortex relies on a tightly controlled schedule, wherein cortical progenitors initially expand by symmetric divisions, then sequentially generate neurons of the deep and superficial cortical layers by asymmetr...
Ascl1 promotes OPC specification across species and central nervous system regions and its gliogenic function is regulated by phosphorylation [0.03%]
Ascl1促进不同物种和中枢神经系统区域的少突胶质前体细胞分化其胶质生成功能受磷酸化调节
Aleezah Balolia,Kimberly A Arena,Anas Shahood et al.
Aleezah Balolia et al.
In the developing central nervous system (CNS), neural progenitors first generate neurons before making astrocytes and oligodendrocytes. This transition from neurogenesis to gliogenesis represents a fundamental developmental switch in the v...
Temperature reorganises developmental time during thyroid hormone-driven fish metamorphosis [0.03%]
温度通过甲状腺激素驱动重新组织鱼变态的发育时间
Emma Gairin,Stefano Vianello,Billy Moore et al.
Emma Gairin et al.
The development of organisms with complex life cycles relies on precise endocrine coordination to link environmental cues with morphogenetic programs. In teleost fish, thyroid hormones (TH) play a central role in post-embryonic development ...
Cell and Tissue Mechanics in 3-D Organ Morphogenesis: Insights from Drosophila Pupal Retina Development [0.03%]
果蝇幼虫视网膜发育中的三维器官形态发生：细胞和组织力学的见解
Jacob R Decker,Irmak Altinok,Ilaria Rebay
Jacob R Decker
Morphogenesis requires dynamic changes in cell and tissue mechanics. Because organs are complex multi-cellular structures that develop slowly, understanding how they acquire their unique 3-D forms requires in vivo experimental systems that ...
An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish [0.03%]
用于激活斑马鱼FGF，BMP和Nodal信号的光遗传学工具包
Leanne E Iannucci,Velanganni Selvaraj Maria Thomas,William K Anderson et al.
Leanne E Iannucci et al.
Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in basic and translational research. Here, ...
TGFβ signaling is required during human and chick Neural Crest formation [0.03%]
TGFβ信号在人和鸡神经 crest形成过程中是必需的
Gustavo A Gomez,Bhaval Parmar,Man Wong et al.
Gustavo A Gomez et al.
Neural crest (NC) cells are multipotent cells unique to vertebrates that arise early in development, at the edge of the neural plate, and subsequently undergo an epithelial to mesenchymal transition, migrate throughout the body, and differe...
Pre-fertilization egg coat dynamics in Phallusia philippinensis (Tunicata, Ascidiacea) [0.03%]
菲律宾菲氏四膜虫受精前卵被囊动态变化（尾触手亚门，樽海鞘目）
Kana Hanazaki,Noburu Sensui,Keita Kinjo et al.
Kana Hanazaki et al.
In externally fertilizing species such as ascidians, gametes are released into the surrounding seawater, which makes the fertilization process highly sensitive to environmental conditions. In the ascidian Phallusia philippinensis, the ovidu...
Non-neural crest lineage contributions to the enteric nervous system: Moving a 50 year conclusion [0.03%]
迁移到肠神经系统中的非神经嵴细胞系成分：重新审视半个世纪前的结论
Henry M Sucov,Takako Makita
Henry M Sucov
It is considered an established fact that the entirety of the autonomic nervous system, including the enteric nervous system (ENS), is derived from neural crest. This conclusion is based on classical quail-chick grafting studies conducted b...