Identification of a set of transcriptional regulators involved in the temporal regulation of neuronal subtype differentiation [0.03%]
参与神经亚型分化时间调控的一组转录调节因子的鉴定
Daisuke Hisamatsu,Hiroyuki Hasegawa,Hayato Naka-Kaneda et al.
Daisuke Hisamatsu et al.
Complex neural activity in the mammalian central nervous system are achieved through the coordinated function of diverse neuronal subtypes. The sequential generation of distinct types of neurons from neural progenitor cells during developme...
Integrating molecular studies and clinical disease models to provide mechanistic insight into neurodevelopment: guidance from FOXG1 syndrome [0.03%]
结合分子研究和临床疾病模型，从FOXG1综合征中获得机制性见解以推动神经发育研究
Holly O&#x;Shea,Meagan L Collins Hutchinson,Jae W Lee et al.
Holly O&#x;Shea et al.
Neurodevelopment relies on precise coordination across molecular, cellular, and circuit-level processes. Conventional studies into neurodevelopmental gene function are primarily guided by tissue- or cell-type-specific expression patterns an...
The human THRB thyroid hormone receptor gene and the puzzle of retinal disease phenotypes [0.03%]
人THRB甲状腺激素受体基因与视网膜疾病表型的难题
Douglas Forrest,Lily Ng,Young-Wook Cho et al.
Douglas Forrest et al.
The THRB thyroid hormone receptor gene has attracted growing attention for its role in retinal development and disease. This gene has particularly critical roles in cone photoreceptors, the specialized cells that mediate color vision and hi...
Vishakha Vishwakarma,Thao Phuong Le,Deborah Obadofin et al.
Vishakha Vishwakarma et al.
Folded gastrulation (Fog), a secreted ligand for a G protein-coupled receptor (GPCR), is a key regulator of cell shape changes during epithelial morphogenesis. During Drosophila embryogenesis, fog is expressed in multiple invaginating tissu...
Castor specifies NB5-2 late-born interneuron molecular identity and premotor connectivity [0.03%]
castor确定NB5-2晚生成中间神经元的分子身份和前运动连接性
Heather Q Pollington,Megan R Radler,Kristen M Lee et al.
Heather Q Pollington et al.
Sensory-motor integration requires proper connectivity of interneurons within the central nervous system (CNS). Unique interneuron identity, defined by a collection of features that includes expression of transcription factors (TFs; molecul...
Sustained ERK signaling couples the injury response to organizer formation during Hydra head regeneration [0.03%]
持续的ERK信号传导在水母头部再生过程中将损伤反应与组织形成相结合
I Y Juanico,A W Stockinger,A K Virgen et al.
I Y Juanico et al.
Regenerative abilities vary widely across animals, even among closely related species, and a central challenge is to compare their gene regulatory networks (GRNs) to determine which components and regulatory connections are conserved or div...
The role of transcription-coupled nucleotide excision repair (TC-NER) during mammalian forebrain development [0.03%]
转录偶联的核苷酸切除修复在哺乳动物前脑发育中的作用
Smruti Patel,Morgan Moser,Natalie M Miller et al.
Smruti Patel et al.
Mechanisms that maintain genome integrity are crucial for coordinating transcription that drives mammalian forebrain development. Neural progenitor cells and differentiating neurons in the developing forebrain sustain high transcriptional a...
Introduction to Developmental Biology Special Issue: Extraembryonic Tissues - Perspectives [0.03%]
发育生物学专刊：额外胚胎组织-新视角介绍
Karen M Downs
Karen M Downs
Neuron-originated Dachshund regulates tracheal tubulogenesis via Lola-Slit axis in Drosophila [0.03%]
神经源Dachshund通过Lola-Slit轴调控果蝇气管发育中的管腔形成
Junzhi Zhu,Wenshuo Zhang,Bo Dong
Junzhi Zhu
Abnormal morphogenesis causes dysfunction of biological tubes and thus is associated with various diseases. However, the underlying regulatory mechanisms for biological tubulogenesis are not fully understood, especially on the cooperation a...
Bioelectric control of tissue mechanics: Effect of membrane potential on somite deformability in chick embryos [0.03%]
生物电对组织力学的控制：膜电位对鸡胚节片变形性的影响
Manohara Mahadeva,Sebastian Niestępski,Magdalena Kowacz
Manohara Mahadeva
Somite segmentation is a crucial process during early embryogenesis, where the timing of somite emergence and somite growth have to be precisely coordinated. Our recent findings established membrane potential (Vm) as a key factor that synch...