Hidekazu Naganuma,Koichiro Miike,Tomoko Ohmori et al.
Hidekazu Naganuma et al.
Recent advances in stem cell biology have enabled the generation of kidney organoids in vitro, and further maturation of these organoids is observed after experimental transplantation. However, the current organoids remain immature and thei...
Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression [0.03%]
视黄醇可调节神经内分泌肿瘤生长和转移的代谢重编程
Chun-Shiu Wu,Yu-Fen Lu,Yu-Hsiu Liu et al.
Chun-Shiu Wu et al.
Nodal signaling is essential for mesoderm and endoderm formation, as well as neural plate induction and establishment of left-right asymmetry. However, the mechanisms controlling expression of Nodal pathway genes in these contexts are not f...
The Caudal ParaHox gene is required for hindgut development in the mollusc Tritia (a.k.a. Ilyanassa) [0.03%]
腹部分节基因paraHox在软体动物后肠发育中是必需的
Adam B Johnson,J David Lambert
Adam B Johnson
Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but...
Mutations in non-muscle myosin 2A disrupt the actomyosin cytoskeleton in Sertoli cells and cause male infertility [0.03%]
非肌肉肌球蛋白2A突变破坏支持细胞中的肌动蛋白-肌球蛋白细胞骨架并导致男性不育
Derek C Sung,Mohsin Ahmad,Connie B Lerma Cervantes et al.
Derek C Sung et al.
Mutations in non-muscle myosin 2A (NM2A) encompass a wide spectrum of anomalies collectively known as MYH9-Related Disease (MYH9-RD) in humans that can include macrothrombocytopenia, glomerulosclerosis, deafness, and cataracts. We previousl...
The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously [0.03%]
线虫中的类型II整合型内质网膜蛋白VAP-B同源物被切割释放N末端MSP结构域以非自主性地发送信号
Hala Zein-Sabatto,Tim Cole,Hieu D Hoang et al.
Hala Zein-Sabatto et al.
VAMP/synaptobrevin-associated protein B (VAP-B) is a type II ER membrane protein, but its N-terminal MSP domain (MSPd) can be cleaved and secreted. Mutations preventing the cleavage and secretion of MSPd have been implicated in cases of hum...
Trim-Away mediated knock down uncovers a new function for Lbh during gastrulation of Xenopus laevis [0.03%]
利用Trim-Away介导的敲低技术发现Lbh在非洲爪蟾原肠运动过程中的新功能
Emma Weir,Gretchen McLinden,Dominique Alfandari et al.
Emma Weir et al.
We previously identified the protein Lbh as necessary for cranial neural crest (CNC) cell migration in Xenopus through the use of morpholinos. However, Lbh is a maternally deposited protein and morpholinos achieve knockdowns through prevent...
Rethinking embryology in vitro: A synergy between engineering, data science and theory [0.03%]
重塑体外胚胎学：工程、数据科学与理论的协同作用
Nicola Gritti,David Oriola,Vikas Trivedi
Nicola Gritti
Pluripotent stem cells, in the recent years, have been demonstrated to mimic different aspects of metazoan embryonic development in vitro. This has led to the establishment of synthetic embryology: a field that makes use of in vitro stem ce...
Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells [0.03%]
非编码RNA在牙周韧带间充质干细胞成骨表型获得过程中对RUNX2转录后加工的抑制作用
Rahyza I F Assis,Geórgia da S Feltran,Maria Eduarda Salomão Silva et al.
Rahyza I F Assis et al.
Mesenchymal stem cells are candidates for therapeutic strategies in periodontal repair due to their osteogenic potential. In this study, we identified epigenetic markers during osteogenic differentiation, taking advantage of the individual ...
A serpin is required for ectomesoderm, a hallmark of spiralian development [0.03%]
丝心蛋白对外中胚层的形成是必需的，这是spiralian发育的一个标志
Longjun Wu,J David Lambert
Longjun Wu
Among animals, diploblasts contain two germ layers, endoderm and ectoderm, while triploblasts have a distinct third germ layer called the mesoderm. Spiralians are a group of triploblast animals that have highly conserved development: they s...
The apical cell - An enigmatic somatic cell in leech ovaries - Structure and putative functions [0.03%]
顶体细胞——蚯蚓卵巢中一个神秘的体细胞——结构和假想功能
Szymon Gorgoń,Piotr Świątek
Szymon Gorgoń
Although somatic cells play an integral role in animal gametogenesis, their organization and function are usually poorly characterized, especially in non-model systems. One such example is a peculiar cell found in leech ovaries - the apical...