Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure [0.03%]
凋亡参与维持神经管闭合后的中脑和间脑顶板的特性
Yudai Matsumoto,Yoshifumi Yamaguchi,Misato Hamachi et al.
Yudai Matsumoto et al.
Apoptosis, a major form of programmed cell death, is massively observed in neural plate border and subsequently in the roof plate (RP). While deficiency of apoptosis often results in brain malformations including exencephaly and hydrocephal...
Cell shape changes during larval body plan development in Clytia hemisphaerica [0.03%]
Clytia hemisphaerica幼虫身体发育过程中细胞形状的变化
Yulia Kraus,Sandra Chevalier,Evelyn Houliston
Yulia Kraus
The cnidarian "planula" larva shows radial symmetry around a polarized, oral-aboral, body axis and comprises two epithelia cell layers, ectodermal and endodermal. This simple body plan is set up during gastrulation, a process which proceeds...
FMR1 loss in a human stem cell model reveals early changes to intrinsic membrane excitability [0.03%]
人类干细胞模型中FMR1的丢失揭示了膜内在兴奋性早期变化
Sara G Susco,Mario A Arias-García,Violeta G López-Huerta et al.
Sara G Susco et al.
Fragile X mental retardation 1 (FMR1) encodes the RNA binding protein FMRP. Loss of FMRP drives Fragile X syndrome (FXS), the leading inherited cause of intellectual disability and a leading monogenic cause of autism. While cortical hyperex...
Tie1 regulates zebrafish cardiac morphogenesis through Tolloid-like 1 expression [0.03%]
Tie1通过调节Tolloid样蛋白1的表达来调控斑马鱼心脏形态发生
Claudia Carlantoni,Srinivas Allanki,Zacharias Kontarakis et al.
Claudia Carlantoni et al.
Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learne...
Mia J Konjikusic,Ryan S Gray,John B Wallingford
Mia J Konjikusic
Kinesins are microtubule-based motor proteins that are well known for their key roles in cell biological processes ranging from cell division, to intracellular transport of mRNAs, proteins, vesicles, and organelles, and microtubule disassem...
Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster [0.03%]
Akirin对黑腹果蝇早期tinman启动及其后续心脏形成至关重要
Austin M Howard,Hayley Milner,Madison Hupp et al.
Austin M Howard et al.
The regulation of formation of the Drosophila heart by the Nkx 2.5 homologue Tinman is a key event during embryonic development. In this study, we identify the highly conserved transcription cofactor Akirin as a key factor in the earliest i...
Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP-Smad signaling [0.03%]
Zeb2通过抑制BMP-Smad信号传导来调节视网膜中间神经元和穆勒神经胶质细胞的平衡
Yotam Menuchin-Lasowski,Bar Dagan,Andrea Conidi et al.
Yotam Menuchin-Lasowski et al.
The interplay between signaling molecules and transcription factors during retinal development is key to controlling the correct number of retinal cell types. Zeb2 (Sip1) is a zinc-finger multidomain transcription factor that plays multiple...
Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells [0.03%]
酪蛋白激酶yes关联蛋白1通过胎盘细胞肌动蛋白细胞质骨架组织发生转位
Shota Yamamura,Nanami Goda,Hiroki Akizawa et al.
Shota Yamamura et al.
A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is g...
The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate [0.03%]
果蝇MLR类似COMPASS复合体在细胞命运的不同背景下调节bantam微RNA的表达
David J Ford,Claudia B Zraly,John Hertenstein Perez et al.
David J Ford et al.
The conserved MLR COMPASS-like complexes are histone modifiers that are recruited by a variety of transcription factors to enhancer regions where they act as necessary epigenetic tools for enhancer establishment and function. A critical in ...
Mouse models to study the pathophysiology of combined methylmalonic acidemia and homocystinuria, cblC type [0.03%]
用于研究合并型甲基马尿酸血症和同型胱氨酸尿症（cblC 型）病理生理的鼠类模型
Tiffany Chern,Annita Achilleos,Xuefei Tong et al.
Tiffany Chern et al.
Combined methylmalonic acidemia and homocystinuria, cblC type, is the most common inherited disorder of cobalamin metabolism and is characterized by severe fetal developmental defects primarily impacting the central nervous system, hematopo...