Chemical and Microbiological Stability Supporting Extended BUDs in Pentravan® Based Transdermal Preparations [0.03%]
基于Pentravan的透皮贴剂延长有效期的支持性化学和微生物稳定性研究
Hudson Polonini,Carolina Schettino Kegele,Bruna Marianni
Hudson Polonini
Transdermal drug delivery represents an important strategy in personalized medicine, offering advantages such as avoidance of first-pass metabolism, improved adherence, and sustained plasma concentrations. In compounding practice, the assig...
Stability Evaluation of Compounded Benzocaine, Lidocaine, and Tetracaine in VersaPro™ Cream Base [0.03%]
苯佐卡因、利多卡因和四氨西平复合物在VersaPro™ 基质膏剂中的稳定性研究
Mihaela Friciu,Ouafa Benzina,Kathryn Hunt et al.
Mihaela Friciu et al.
Compounded Benzocaine (20%), Lidocaine (6%), and Tetracaine (4%) in VersaPro™ Cream Base was studied to evaluate the chemical, physical, and microbial stability over a 180-day period. Preparations were stored in ambient conditions in tight...
Formulation and In-Vitro Characterization of Gastroretentive Effervescent Floating Tablets of Meloxicam [0.03%]
制备和体外评价美洛昔康胃滞留型发泡漂浮片处方及制备和体外评价美洛昔康胃滞留型发泡漂浮片处方及体外评价
Wisam Ghazi Sanad,Haidar Essam Jeleel,Qasim Allawi Bader
Wisam Ghazi Sanad
The present study was undertaken to design and evaluate gastro-retentive effervescent floating tablets of meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), with the aim of prolonging gastric residence time and achieving controlled d...
Ethical and Regulatory Implications of Sourcing Drug X During an FDA-Reported Shortage: 503A vs. 503B Compounding Facilities [0.03%]
食品药品监督管理局报告的药物X短缺期间获得药品的伦理和监管影响：503A与503B混合设施的区别
Hayden R Asbill,W Mark Moore,Scott Asbill
Hayden R Asbill
In the case of an FDA shortage of drug X, an injectable medication, the safer route to supply the drug to hospital systems would be through a 503B outsourcing facility. Unlike 503A pharmacies, 503B outsourcing facilities are permitted to co...
Turning Employees into Compliance Assets: Managing and Preventing Claims Based on Failed OBRA '90 and USP Compliance [0.03%]
从失败的OBRA'90和USP遵守计划中学习：管理员工并预防索赔事件
Michael R Alexander,Jesse Fishman,Matthew D Earl et al.
Michael R Alexander et al.
A strong compliance program requires attention, engagement, and active monitoring of pharmacists and pharmacy professionals. Done well, compliance is routine, consistent, even mundane. Yet these very characteristics can create a culture of ...
L Rad Dillon,Michael Magee
L Rad Dillon
Compounding pharmacies operate in a complex regulatory environment where not all deficiencies carry equal consequences. Traditional checklist-based inspections are effective at verifying compliance with published standards, but they often f...
Vaginal Films as a Patient-Centered Dosage Form: Evaluation of Preferences, Acceptability, and Applicability in Personalized Drug Delivery [0.03%]
以患者为中心的给药剂型：评估阴道膜的偏好、接受度和个性化药物输送适用性
Geraldo Sérgio Farinazzo Vitral,Carolina Costa Vicente Silva,Hudson Caetano Polonini et al.
Geraldo Sérgio Farinazzo Vitral et al.
Vaginal films are emerging as a promising intravaginal drug delivery system, but patient acceptability remains essential for clinical adoption. To assess women's anticipated preferences for vaginal films versus other dosage forms and determ...
Comparing the Effect of Drug, Sodium Carboxymethyl Cellulose and Other Excipients on Shape, Size and Drug Release from the Matrices [0.03%]
药物、盐类及辅料对骨架型缓控释制剂外形、尺寸及释放特性的影响比较研究
Hassan Alhmoud,Yazan Akkam,Omar Alhmoud
Hassan Alhmoud
Purpose: Sodium Carboxymethyl Cellulose (NaCMC) is frequently employed in pharmaceutical formulation. Nevertheless, there are potential interactions between NaCMC and specific drugs, which may have an impact on the stabil...
Comparative Study
International journal of pharmaceutical compounding. 2026 Jan-Feb;30(1):64-77. DOI: 2026
Design and Characterization of Doxepin In-situ Nasal Gel Using Pectin as a Bio-compatible Matrix [0.03%]
使用果胶作为生物相容性基质的多塞平原位鼻用凝胶的设计与表征
Antesh Kumar Jha,Shiv Kumar Srivastava,Mahesh Prasad
Antesh Kumar Jha
The goal of the current study is to formulate a Doxepin hydrochloride ion triggered trans-nasal gel. The developed formulations were evaluated for gel strength, gelation time, viscosity, mucoadhesion strength, ex-vivo drug permeability drug...
Lydia M Theodoropoulou,Niamh A Cullen
Lydia M Theodoropoulou
Background: This retrospective study addresses the question of inadequate cholinergic output in Allergic Rhinosinusitis (ARS) and the feasibility of its treatment with cholinergics. Pilocarpine, a muscarinic-receptor agon...