Evaluating the Utilization and Cost Analysis of High-dose Thiamine when Compounded or Administered Via Intravenous Push at an Academic Medical Center [0.03%]
学术医学中心高剂量维生素B1配制或推注的利用和成本分析评估
Kaitlin Blotske,Brian Murray,Rob MacLaren et al.
Kaitlin Blotske et al.
Purpose: Thiamine doses greater than 200 mg are typically prepared as an IV piggyback (IVPB) and administered over 30 minutes to reduce the risk of adverse events (AE) associated with administration. Administration of hig...
Meghan Fletcher,Taylor Patek,Cody Wiley et al.
Meghan Fletcher et al.
Purpose: Administration of naloxone by continuous infusion for treatment of respiratory depression associated with long-acting opioids often necessitates extemporaneous preparations at drug concentrations that exceed the ...
Chemical and Microbiological Stability of Extemporaneous Cardiovascular Suspensions Compounded in Dual Suspending Vehicle System [0.03%]
双悬浮介质系统制备心血管药物混悬液的化学和微生物稳定性研究
Carolina Schettino Kegele,Sarah Taylor,Hudson Polonini
Carolina Schettino Kegele
Extemporaneous compounding plays a critical role in providing individualized pharmacotherapy for pediatric patients who require cardiovascular medications not available in commercially manufactured liquid formulations. This study evaluated ...
Chemical and Microbiological Stability of Benazepril, Candesartan, Disulfiram, Fluconazole, Methocarbamol, and Pentoxifylline in SyrSpend® SF PH4 [0.03%]
盐酸苯那普利、坎地沙坦、双硫醒、氟康唑、甲氧卡巴胺和戊糖菲啶在SyrSpend®SFPH4中的化学和微生物稳定性研究
Carolina Schettino Kegele,Eli Dijyers,Hudson Polonini
Carolina Schettino Kegele
This study evaluated the chemical and microbiological stability of six oral liquid formulations, benazepril hydrochloride, candesartan cilexetil, disulfiram, fluconazole, methocarbamol, and pentoxifylline, compounded in the suspending vehic...
Development and Optimization of Antioxidant Poly Herbal Peel-off Mask using Doe Based Approach [0.03%]
基于DOE的抗氧化植物果皮净化面膜的开发与优化
Devika Ramakrishnan,Jithesh Mr,Jisna Joy et al.
Devika Ramakrishnan et al.
Background: Antioxidants protect the skin from free radicals, which are associated with signs of aging, pigmentation, and loss of elasticity. Combining antioxidants in cosmetic formulations may provide broader antioxidant...
Stability Study of a 100 mg/mL Sodium Benzoate Solution in Water for Parenteral Use [0.03%]
苯甲酸钠水溶液（注射用水）的稳定性研究(100毫克/毫升)
Isabelle St-Jean,Mihaela Friciu,Lola Bonnemain et al.
Isabelle St-Jean et al.
Context: Sodium benzoate is mainly used as a preservative in food and pharmaceuticals and as a treatment for hyperammonemia in urea-cycle disorders. It is typically diluted in 5 or 10% dextrose solutions for intravenous a...
From Gaps to Maturity: How 503B Outsourcing Facilities Can Build a High Performing Supplier and Material Control Program [0.03%]
从差距到成熟：503B外包设施如何建立高效的供应商和物料控制计划
Michael L Magee
Michael L Magee
Supplier and material qualifications are one of the least visible, but most critical, elements of a 503B outsourcing facility's quality system. When it works well, it attracts little attention. When it breaks down, the consequences often ap...
Compounding and Stability Study of Dipyridamole and Clopidogrel Pediatric Oral Suspensions [0.03%]
双嘧达莫和氯吡格雷儿科口服混悬液的制剂学及稳定性研究
Lucile Dho,Said Ait Taleb,Lyna Kireche et al.
Lucile Dho et al.
Dipyridamole and clopidogrel are two antiplatelet agents that can be prescribed off-label in pediatric practice. As commercially available drugs are unavailable, pediatric formulations must be compounded. Both stability-indicating HPLC dosi...
Nanoemulsion Reformulation of Nitrosylcobalamin (NO-Cbl) Enhances Solubility, Stability, and Anti-Tumor Potency [0.03%]
硝基钴胺素(NO-氰钴胺素)纳米乳剂 reformulation 可增强其溶解度、稳定性和抗肿瘤功效
Joseph A Bauer,Annette M Sysel,Michael J Dunphy
Joseph A Bauer
Background: Nitrosylcobalamin (NO-Cbl), a vitamin B12-based nitric oxide donor, has demonstrated selective antitumor activity. However, its translational development has been limited by formulation challenges, including r...