Urinary oxidative stress biomarkers in nephrotoxicity induced by PM2.5 in a rat model [0.03%]
PM₂.５肾毒性大鼠模型尿液氧化应激生物标志物的研究
Jessica Baldriche-Acosta,Marisela Uribe-Ramírez,Juana Narváez-Morales et al.
Jessica Baldriche-Acosta et al.
Objective: The present study evaluated urinary oxidative stress (OxS) biomarkers to explain the extrapulmonary effect of renal function decline due to subchronic inhalation exposure to particles smaller than 2.5 μm, as w...
Temporal evaluation of lung injury following chlorine Inhalation in a ventilated pig model [0.03%]
通气猪模型中氯吸入后肺损伤的时长评价
Matthew Neal,Jill Harvilchuck,David Pressburger et al.
Matthew Neal et al.
Objective: Chlorine (Cl2) is a widely used industrial chemical and toxic human exposures have occurred from Cl2 releases. No approved medical countermeasures (MCMs) exist for Cl2-induced lung injuries. The objective of th...
GRP78 mediates mitochondrial fusion and fission in cigarette smoke-induced inflammatory responses in airway epithelial cells [0.03%]
COPD小气道上皮细胞GRP78介导线粒体融合与分裂的调控作用
Yong Wang,Ya-Jing Li,Chen-Chen Li et al.
Yong Wang et al.
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, with cigarette smoke being a major contributor to epithelial injury. Recent studies have shown that abnormal mito...
Co-existing ambient fine particulate matter exacerbated electronic cigarette toxicity on human respiratory cells [0.03%]
共存的环境细颗粒物加剧了电子烟对人类呼吸道细胞的危害
Guanghe Wang,Wenjing Liu,Yujie Cao et al.
Guanghe Wang et al.
Respiratory co-exposure to ambient PM2.5 and electronic cigarettes (e-cigarettes) frequently occurs in public. However, the combined effects on human respiratory health have not been well documented. To discuss potential co-effects and poss...
Bergapten attenuates sepsis-induced acute lung injury in mice by regulating Th17/Treg balance [0.03%]
bergapten通过调节Th17/Treg平衡减轻小鼠脓毒症诱导的急性肺损伤
Shanqiu Shi,Rui Deng,Renchun Huang et al.
Shanqiu Shi et al.
Background: The abnormality of the immune system caused by infection is a contributor to the organ dysfunctions associated with sepsis. The balance between Th17/Treg cells is essential for maintaining immune homeostasis. ...
Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice [0.03%]
溶血性磷脂酶D抑制剂PLB268对狼疮易感小鼠硅尘诱导的肺纤维化、淋巴组织新生和自身抗体生成的影响
Olivia F McDonald,James G Wagner,Ryan P Lewandowski et al.
Olivia F McDonald et al.
Objective: Acute intranasal (IN) instillation of lupus-prone NZBWF1 mice with crystalline silica (cSiO2) triggers robust lung inflammation that drives autoimmunity. Prior studies in other preclinical models show that solu...
Gene expression changes in mouse lung induced by subacute inhalation of PM10-rich particulate matter [0.03%]
亚急性吸入PM10富集颗粒物诱导小鼠肺组织基因表达变化
Jong-Uk Lee,Jisu Hong,Eunji Park et al.
Jong-Uk Lee et al.
Introduction: Particulate matter (PM) air pollution is associated with an increased incidence of lung diseases, but the underlying mechanisms have not been fully elucidated. In this study, a mouse model of subacute lung i...
Justina R Creppy,Benoit Delache,Julien Lemaitre et al.
Justina R Creppy et al.
Purpose: Airborne pathogen scan penetrate in human respiratory tract and can cause illness. The use of animal models to predict aerosol deposition and study respiratory disease pathophysiology is therefore important for r...
An introduction to the adverse health impacts of inhaled toxicants in global marginalized communities [0.03%]
关于有毒吸入物对全球弱势社区不利健康影响的介绍
Antonio F Saporito,Judith T Zelikoff
Antonio F Saporito
Development of a risk prediction nomogram for delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning [0.03%]
急性一氧化碳中毒患者迟发性脑病风险预测列线图的建立
Ghada N El-Sarnagawy,Fatma M Elgazzar,Mona M Ghonem
Ghada N El-Sarnagawy
Objectives: Delayed neuropsychiatric sequelae (DNS) are critical complications following acute carbon monoxide (CO) poisoning that can substantially affect the patient's life. Identifying high-risk patients for developing...