Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation [0.03%]
暴露于全氟(2-甲基-3-氧己酸)铵盐(GenX)会抑制小鼠肺部对碳黑纳米颗粒的固有免疫反应并刺激肺细胞增殖
Ho Young Lee,Dorothy J You,Alexia J Taylor-Just et al.
Ho Young Lee et al.
Background: Per- and polyfluoroalkyl substances (PFAS) have been associated with respiratory diseases in humans, yet the mechanisms through which PFAS cause susceptibility to inhaled agents is unknown. Herein, we investig...
Co-exposure of peptidoglycan and heat-inactivated Asian sand dust exacerbates ovalbumin-induced allergic airway inflammation in mice [0.03%]
肽聚糖和灭活的亚洲沙尘热共同暴露加重卵清蛋白诱导的小鼠过敏性气道炎症
Kaori Sadakane,Takamichi Ichinose,Teruya Maki et al.
Kaori Sadakane et al.
Aims: Asian sand dust (ASD) comprises soil particles, microorganisms, and various chemical components. We examined whether peptidoglycan (PGN), a structural cell wall component of Gram-positive bacteria, exacerbates ASD-i...
Liver transcriptome analysis reveals biological pathways and transcription factors in response to high ammonia exposure [0.03%]
肝脏转录组分析揭示高氨暴露反应的生物通路和转录因子
Daojie Li,Shuangzhao Chen,Chun Liu et al.
Daojie Li et al.
Aim: Ammonia is a toxic gas that not only causes environmental pollution, but also is harmful to human health after inhalation. Liver is an important detoxification organ that can convert external or metabolized toxic substances into nontox...
Pulmonary toxicity and gene expression changes in response to whole-body inhalation exposure to multi-walled carbon nanotubes in rats [0.03%]
大鼠全身吸入多壁碳纳米管的肺毒性及其基因表达变化响应
Tina M Sager,Christina M Umbright,Gul Mehnaz Mustafa et al.
Tina M Sager et al.
Purpose: To investigate the molecular mechanisms underlying the pulmonary toxicity induced by exposure to one form of multi-walled carbon nanotubes (MWCNT-7).Materials and methods: Rats were exposed, by whole-body inhalation, to air or an a...
A filter-based system mimicking the particle deposition and penetration in human respiratory system for secondhand smoke generation and characterization [0.03%]
一种模仿人呼吸道系统颗粒物沉降和渗透的滤筒式实验系统用于环境烟气的生成及特性研究
Weixing Hao,Kashala Fabrice Kapiamba,Varuni Abhayaratne et al.
Weixing Hao et al.
Introduction: Secondhand smoke endangers both the environment and the health of nonsmokers. Due to the scarcity of repeatable data generated by human subjects, a system capable of generating representative secondhand smok...
World Trade Center dust induces nasal and neurological tissue injury while propagating reduced olfaction capabilities and increased anxiety behaviors [0.03%]
世界贸易中心粉尘导致鼻和神经组织损伤，并传播降低嗅觉能力及增加焦虑行为的特性
Michelle Hernandez,Joshua Vaughan,Terry Gordon et al.
Michelle Hernandez et al.
Objective: Previous in vitro and in vivo World Trade Center particulate matter (WTCPM) exposure studies have provided evidence of exposure-driven oxidative/nitrative stress and inflammation on respiratory tract and aortic tissues. What rema...
Successful treatment of pulmonary injury due to nitrogen oxide exposure with extracorporeal membrane oxygenation: a report of two cases and literature review [0.03%]
体外膜肺氧合治疗氮氧化物致肺损伤2例及文献复习
Jian Liu,Yongquan Dong,Xuejie Li et al.
Jian Liu et al.
Background: Severe nitrogen oxide poisoning can lead to life-threatening pulmonary injury.Methods: we report two cases of severe nitrogen-oxide-induced hypoxia treated with veno-venous extracorporeal membrane oxygenation (ECMO). After expos...
A controlled chamber study of effects of exposure to diesel exhaust particles and noise on heart rate variability and endothelial function [0.03%]
一项关于柴油颗粒和噪声暴露对心率变异性及内皮功能影响的室内操控研究
Leo Stockfelt,Yiyi Xu,Anders Gudmundsson et al.
Leo Stockfelt et al.
Background: Adverse cardiovascular effects are associated with both diesel exhaust and road traffic noise, but these exposures are hard to disentangle epidemiologically. We used an experimental setup to evaluate the impac...
Randomized Controlled Trial
Inhalation toxicology. 2022;34(5-6):159-170. DOI:10.1080/08958378.2022.2065388 2022
Ammonia exposure by intratracheal instillation causes severe and deteriorating lung injury and vascular effects in mice [0.03%]
气管内给予氨水会导致小鼠严重的且持续恶化的肺损伤和血管效应
Linda Elfsmark,Lina Ågren,Christine Akfur et al.
Linda Elfsmark et al.
Objective: Ammonia (NH3) is a corrosive alkaline gas that can cause life-threatening injuries by inhalation. The aim was to establish a disease model for NH3-induced injuries similar to acute lung injury (ALI) described i...
A procedure to detect and identify specific chemicals of potential inhalation toxicity concern in aerosols [0.03%]
检测和识别气溶胶中潜在吸入毒性的特定化学物质的程序
Theodore P Klupinski,Robert A Moyer,Po-Hsu Allen Chen et al.
Theodore P Klupinski et al.
Objective: Understanding the potential inhalation toxicity of poorly characterized aerosols is challenging both because aerosols may contain numerous chemicals and because it is difficult to predict which chemicals may pr...