Challenges and complexities in treating ammonia-induced lung injuries: ammonia disrupts cellular membranes and induces severe damage [0.03%]
氨致肺损伤的治疗挑战与复杂性：破坏细胞膜诱导严重损伤
Gregory Rankin,Terese Karlsson,Åsa Gustafsson et al.
Gregory Rankin et al.
Objective: Ammonia (NH3) inhalation is a common occupational exposure, causing injuries similar to acute lung injury (ALI). Medical management is limited to supportive care, as no specific antidotes are currently availabl...
Sex modifies response to ozone and nitrogen dioxide: a controlled human exposure study [0.03%]
性别对臭氧和二氧化氮响应的影响：一项人体暴露实验研究
Jairus C Pulczinski,Ana G Rappold,Robert B Devlin et al.
Jairus C Pulczinski et al.
Background: Ozone (O3) and nitrogen dioxide (NO2) are highly reactive gases associated with all cause-mortality. Epidemiology studies suggest that the risk from O3 and NO2 exposure is modified by sex. O3 is more strongly ...
Genetic ablation of p16 leads to pulmonary remodeling, pro-senescence response, and immune modulation in mice exposed to low-dose, Sub-chronic, environmental tobacco smoke [0.03%]
p16基因消融致小鼠低剂量、亚慢性环境烟草烟雾暴露引起肺重塑、促衰老反应及免疫调控
Thivanka Muthumalage,Irfan Rahman
Thivanka Muthumalage
Objective: Cyclin-dependent kinase inhibitor 2 A, CDKN2A/p16INK4a (p16), is a gene involved in regulating the cell cycle, cellular senescence, and inflammatory responses. The role of p16 in pulmonary immune-inflammatory a...
Efficacy of different oxygen delivery methods in carbon monoxide poisoning: a prospective observational study [0.03%]
不同给氧方法一氧化碳中毒疗效的前瞻性观察研究
Safa Donmez,Alp Sener,Nurullah Ishak Isık et al.
Safa Donmez et al.
Objective: Carbon monoxide (CO) poisoning impairs oxygen transport by forming carboxyhemoglobin (COHb). Normobaric oxygen (NBO) is standard therapy, but its COHb elimination rate is slow. This study compared the effective...
Evaluation of protective effects of tannic acid/iron complex against lung fibrosis induced by bleomycin in rat [0.03%]
评估棓酸铁复合物对雷公藤内酯醇致小鼠肺纤维化的保护作用
Amir Siahpoosh,Narges Atefipour,Paria Javam et al.
Amir Siahpoosh et al.
Objective(s): Pulmonary fibrosis (PF) is a seriousand advancing respiratory condition that arises from various contributing factors. Bleomycin (BLM) is a chemotherapeutic drug known to cause different side effects, includ...
Fuat Karakuş,Burak Kuzu
Fuat Karakuş
Objective: Endosulfan, an organochlorine pesticide, consists of two isomers (α-Endosulfan and β-Endosulfan) and a primary metabolite, Endosulfan sulfate (END-SO4). Due to its pervasive environmental contamination and ha...
Episodic ozone exposure over two weeks alters pulmonary inflammation and gene expression in Long-Evans rats [0.03%]
两周内间歇性臭氧暴露可改变长岛大鼠肺部炎症和基因表达水平
Janice A Dye,Makala M Moore,Helen H Nguyen et al.
Janice A Dye et al.
Objective: Elevated exposure to ozone (O3) may occur episodically over short windows of time. However, laboratory investigations have consistently shown that repeated ozone exposures produce an adaptation response, reduci...
A review of popular vaping misconceptions: redefining ENDS safety and usage risks [0.03%]
解读流行的蒸气制品谬论：重新定义电子烟的安全性和使用危害
Shaligram Sharma,Laura Crotty Alexander,Maureen Meister et al.
Shaligram Sharma et al.
The widespread use of electronic nicotine delivery systems (ENDS) among youth and adults has become a significant public health concern. Approximately 19.6% of middle and high school students in the United States have reported using ENDS co...
Impact of secondhand smoke and e-cigarette aerosol on overweight or obesity in adolescents: a network pharmacology and toxicology study [0.03%]
二手烟及电子烟气溶胶对青少年超重或肥胖影响的网络药理学和毒理学研究
Yalan Liu,Hong Xiao,Hua Zong et al.
Yalan Liu et al.
Objective: Rising childhood obesity is a global concern, with environmental tobacco exposure as a potential risk factor. However, the mechanisms linking secondhand smoke and e-cigarette aerosol to adolescent obesity remai...
Fragrance inhalation toxicity assessment: a proactive testing strategy using ex vivo precision cut lung slices (PCLuS) for the prioritization of selected aroma ingredients candidates for in vivo testing [0.03%]
香水吸入毒理评估：一种前瞻性测试策略，使用体外精密切割肺片（PCLuS）对候选芳香成分进行体内试验优先级划分
Tizia Thoma,Olga Lemke,Lan Ma-Hock et al.
Tizia Thoma et al.
Objective: To date, exposure thresholds for fragrance chemicals are most often extrapolated from oral administration data. Due to limited inhalation toxicity data, the potentially high exposure levels toward fragrances - ...