Hydrophobic unnatural base pair promotes trigger loop closure and catalysis in cellular RNA polymerase independent of hydrogen bonding [0.03%]
非氢键促进疏水碱基对促进细胞RNA聚合酶触发环闭合和催化独立性
Qingrong Li,Peini Hou,Michiko Kimoto et al.
Qingrong Li et al.
Expanded genetic alphabets based on synthetic nucleotides offer a powerful strategy to increase the chemical diversity and functional potential of nucleic acids. Hydrophobic unnatural base pairs (UBPs) represent a unique class of UBPs that ...
Mapping the architecture of protein complexes in Arabidopsis using cross-linking mass spectrometry [0.03%]
采用交联质谱法绘制拟南芥蛋白质复合物的结构图
Cao Son Trinh,Ruben Shrestha,Pengzhi Mao et al.
Cao Son Trinh et al.
Capturing molecular machines in action is essential for understanding protein complex architecture, cellular regulation, and gene function. Here, we present a large-scale structural proteomics resource for Arabidopsis thaliana generated usi...
A solution to generalized learning from small training sets found in infants' repeated visual experiences of individual objects [0.03%]
婴儿通过重复的视觉经验解决从少量训练样本中进行泛化学习的问题
Frangil M Ramirez,Elizabeth M Clerkin,David J Crandall et al.
Frangil M Ramirez et al.
One-year-old infants rapidly form and generalize categories from idiosyncratic experiences of very few exemplars of those categories. Here we provide evidence on the statistics of infants' daily-life visual experiences for 8 object categori...
Samuel G Pearson,Matthew J Hornsey,S Alexander Haslam
Samuel G Pearson
Samuel G Pearson,Matthew J Hornsey,S Alexander Haslam
Samuel G Pearson
Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor [0.03%]
人IL4I1偏好芳香族氨基酸的进化历程及其与广谱 specificity L-氨基酸氧化酶始祖的关系
Marta Massari,Jonatan Caroli,Marco Malatesta et al.
Marta Massari et al.
IL4I1, a human L-amino acid oxidase (LAAO), has drawn considerable interest for its role in catabolism with implications for cancer biology and immune modulation. The function and activity of this enzyme in humans contrast with the cytotoxi...
Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor [0.03%]
人IL4I1芳香族氨基酸偏好的进化来自一个广泛的L-氨基酸氧化酶祖先
Marta Massari,Jonatan Caroli,Marco Malatesta et al.
Marta Massari et al.
IL4I1, a human L-amino acid oxidase (LAAO), has drawn considerable interest for its role in catabolism with implications for cancer biology and immune modulation. The function and activity of this enzyme in humans contrast with the cytotoxi...
Recursive mentalizing and public salience in the perception of common knowledge [0.03%]
递归式心智理论与公共突出性在常识知觉中的作用
Julian De Freitas,Yuhui Huang,Steven Pinker
Julian De Freitas
Common knowledge-what everyone knows that everyone knows, ad infinitum-is theoretically required for coordination. But a finite mind cannot represent infinitely embedded propositions, and even a few are cognitively taxing. We propose that p...
MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration [0.03%]
微RNA-34a通过CXCR4/CXCL12通路抑制KLF2促进年龄相关性黄斑变性的病理血管生成
Jason J Colasanti,Andrea Santeford,Joseph B Lin et al.
Jason J Colasanti et al.
Age-related macular degeneration (AMD), characterized by pathologic choroidal neovascularization (CNV), is a leading cause of vision loss in the elderly. Vascular endothelial growth factor A (VEGFa) antagonists can prevent acute vision loss...
TBC1D23-AAVR interaction drives endosome-to-TGN trafficking required for rAAV transduction [0.03%]
TBC1D23-AAVR相互作用驱动rAAV转导所需的内吞体到TGN转运
Xiujuan Zhang,Ariful Habib,Shane McFarlin et al.
Xiujuan Zhang et al.
The adeno-associated virus receptor (AAVR; also known as KIAA0319L) is the proteinaceous receptor required for the transduction of multiserotype adeno-associated viruses (AAVs). While the extracellular polycystic kidney disease (PKD) domain...