Gut microbiota dysbiosis exacerbates post-stroke depression via microglial NLRP3 inflammasome activation [0.03%]
肠道微生物群失调通过小胶质细胞NLRP3炎症小体活化加重中风后抑郁症
Yuxiao Chen,Liqiang Yu,Lulu Zhang et al.
Yuxiao Chen et al.
Background: Post-stroke depression (PSD) is a neuropsychiatric complication prevalent among stroke survivors. Emerging evidence suggests that dysregulation of the microbiota-gut-brain axis is implicated in the pathogenesi...
Meret Möller,Johanna A Nieweler,Vadim V Nikulin et al.
Meret Möller et al.
Rapid-onset dystonia-parkinsonism (RDP) is a rare neurological disorder caused by mutations in the ATP1A3 gene. Symptoms are characterized by a dystonia-parkinsonism. Recently, experimental studies have shown that the pathophysiology of the...
Amplifying blood brain barrier injury: Neuroinflammation propagates cerebral microbleed cascades in cerebral small vessel disease, driving dementia [0.03%]
放大血脑屏障损伤：神经炎症在脑小血管病中传播脑微出血级联反应，驱动痴呆发生发展
Mengxin Wang,Mofan Li,Haowen Yuan et al.
Mengxin Wang et al.
Objective: As an important cause of cognitive impairment, Cerebral Small Vessel Disease (CSVD) is characterized by structural and functional abnormalities of the Blood-Brain Barrier (BBB). To explore the association betwe...
Central amygdala-substantia nigra pars compacta circuit mediates anxiety- and depression-like behaviors in MPTP-treated mice [0.03%]
中央杏仁核-黑质致密部环路介导MPTP诱导的小鼠焦虑和抑郁样行为
Haixia Tang,Yiheng Li,Pengcheng Huang et al.
Haixia Tang et al.
Parkinson's disease (PD) is characterized by progressive degeneration of substantia nigra pars compacta (SNc) dopamine (DA) neurons, leading to motor dysfunction. Non-motor symptoms of PD, such as neuropsychiatric symptoms (anxiety and depr...
The TrkA agonist gambogic amide promotes neuroplasticity and recovery following ischemic stroke [0.03%]
特异性激活TrkA受体的小分子化合物促进缺血性脑卒中后神经可塑性和功能恢复
Shih-Yen Tsai,Elizabeth Gino,Duane Nguyen et al.
Shih-Yen Tsai et al.
Recovery from ischemic brain damage cause by stroke is limited unless treatments are implemented within a narrow time window to increase blood flow and reduce tissue damage to the affected area of the brain. Our laboratory has pioneered alt...
Dietary and exercise interventions improve cognition and alter hippocampal transcriptomics in a mouse model of the metabolic syndrome [0.03%]
饮食和运动干预可改善代谢综合征小鼠模型的认知并改变海马转录组学
Pongrat Jaisil,Stephanie A Eid,Kai Guo et al.
Pongrat Jaisil et al.
Metabolic syndrome (MetS) is a major global health concern that continues to rise in prevalence and further augments disease burden by predisposing individuals to cognitive impairment (CI). Managing MetS through lifestyle habits or interven...
Circadian clock protein Bmal1 protects against transient focal cerebral ischemia in mice by regulating master signals controlling cell survival and metabolism [0.03%]
昼夜节律钟蛋白Bmal1通过调节控制细胞存活和代谢的主信号来保护小鼠免受短暂性局灶性脑缺血的影响
Mustafa C Beker,Elif Sertel Evren,Elif Özbay et al.
Mustafa C Beker et al.
The circadian rhythm, regulated by the suprachiasmatic nucleus through a transcription-translation feedback loop, plays a crucial role in maintaining homeostasis and optimizing physiological processes based on time of day. Recent studies ha...
Effects of cranial X-ray irradiation in Presymptomatic 3 × Tg-AD mice [0.03%]
颅部X射线照射对无症状期3 × Tg-AD小鼠的影响
Wei Cheng,Yanxi Ma,Feifei Gao et al.
Wei Cheng et al.
Background: Recently, several animal studies have demonstrated the therapeutic potential of low-dose radiation therapy (LDRT) for Alzheimer's disease (AD), especially in decreasing amyloid-beta (Aβ) plaques. However, cli...
Diabetic encephalopathy models: A systematic review from cells to animals [0.03%]
糖尿病性脑病模型的系统综述：从细胞到动物模型
Yongjie Xu,Changyu Huang,Yiqiong Zhang et al.
Yongjie Xu et al.
Diabetic encephalopathy, a significant complication of diabetes, is primarily characterized by cognitive dysfunction, manifesting as deficits in learning and memory. In recent years, the global rise in diabetes prevalence has been parallele...
Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies [0.03%]
评估年龄和治疗对蛋白病小鼠模型中神经炎症相关蛋白质的影响
Amelia D Dahlén,Sahar Roshanbin,Nadja M Bucher et al.
Amelia D Dahlén et al.
Neuroinflammation plays a key role in Alzheimer's disease (AD), but the actions of microglial mediators may vary across stages of Aβ pathology. While drugs targeting brain immune responses are advancing to clinical trials, biomarkers to mo...